Multimodal network dynamics underpinning working memory
Complex human cognition arises from the integrated processing of multiple brain systems. However, little is known about how brain systems and their interactions might relate to, or perhaps even explain, human cognitive capacities. Here, we address this gap in knowledge by proposing a mechanistic fra...
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| Veröffentlicht in: | Nature communications 2020-06, Vol.11 (1), p.3035-3035, Article 3035 |
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| creator | Murphy, Andrew C. Bertolero, Maxwell A. Papadopoulos, Lia Lydon-Staley, David M. Bassett, Danielle S. |
| description | Complex human cognition arises from the integrated processing of multiple brain systems. However, little is known about how brain systems and their interactions might relate to, or perhaps even explain, human cognitive capacities. Here, we address this gap in knowledge by proposing a mechanistic framework linking frontoparietal system activity, default mode system activity, and the interactions between them, with individual differences in working memory capacity. We show that working memory performance depends on the strength of functional interactions between the frontoparietal and default mode systems. We find that this strength is modulated by the activation of two newly described brain regions, and demonstrate that the functional role of these systems is underpinned by structural white matter. Broadly, our study presents a holistic account of how regional activity, functional connections, and structural linkages together support integrative processing across brain systems in order for the brain to execute a complex cognitive process.
Working memory is a critical component of executive function that allows people to complete complex tasks in the moment. Here, the authors show that this ability is underpinned by two newly defined brain networks. |
| doi_str_mv | 10.1038/s41467-020-15541-0 |
| format | Article |
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Working memory is a critical component of executive function that allows people to complete complex tasks in the moment. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murphy, Andrew C.</au><au>Bertolero, Maxwell A.</au><au>Papadopoulos, Lia</au><au>Lydon-Staley, David M.</au><au>Bassett, Danielle S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multimodal network dynamics underpinning working memory</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><stitle>NAT COMMUN</stitle><addtitle>Nat Commun</addtitle><date>2020-06-15</date><risdate>2020</risdate><volume>11</volume><issue>1</issue><spage>3035</spage><epage>3035</epage><pages>3035-3035</pages><artnum>3035</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Complex human cognition arises from the integrated processing of multiple brain systems. 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Working memory is a critical component of executive function that allows people to complete complex tasks in the moment. Here, the authors show that this ability is underpinned by two newly defined brain networks.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32541774</pmid><doi>10.1038/s41467-020-15541-0</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8702-3923</orcidid><orcidid>https://orcid.org/0000-0002-6183-4493</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 38/39 59/36 59/57 631/378/116 631/378/1595/1636 631/378/2649 Adult Brain Brain - physiology Brain Mapping Cognition Cognitive ability Critical components Executive function Female Humanities and Social Sciences Humans Individuality Memory Memory, Short-Term multidisciplinary Multidisciplinary Sciences Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Short term memory Structure-function relationships Substantia alba Task complexity Young Adult |
| title | Multimodal network dynamics underpinning working memory |
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