NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy

DNA hypermethylation has been widely observed in temporal lobe epilepsy (TLE), in which NR4A1 knockdown has been reported to be able to alleviate seizure severity in mouse model, while the underlying methylation-imaging pathway modulated by aberrant methylation levels of NR4A1 remains to be clarifie...

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Veröffentlicht in:	Frontiers in neuroscience 2020-07, Vol.14, p.727-727, Article 727
Hauptverfasser:	Zhi, Dongmei, Wu, Wenyue, Xiao, Bo, Qi, Shile, Jiang, Rongtao, Yang, Xingdong, Yang, Jian, Xiao, Wenbiao, Liu, Chaorong, Long, Hongyu, Calhoun, Vince D., Long, Lili, Sui, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Anisotropy Cerebellum Cingulum Cognitive ability Convulsions & seizures Correlation analysis Deoxyribonucleic acid DNA DNA methylation Epigenetics Epilepsy Executive function fractional anisotropy functional connectivity Functional magnetic resonance imaging Gene expression Genetic testing gray matter volume Life Sciences & Biomedicine Medical imaging methylation levels of NR4A1 multimodal fusion Neural networks Neuroimaging Neuroscience Neurosciences Neurosciences & Neurology Putamen Science & Technology Seizures Semiotics Studies Substantia grisea Temporal lobe temporal lobe epilepsy Thalamus
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