Epigallocatechin 3‐gallate attenuates arthritis by regulating Nrf2, HO‐1, and cytokine levels in an experimental arthritis model
Epigallocatechin 3‐gallate (EGCG) is a polyphenol that has been shown to have antioxidant and anti‐inflammatory effects. In this study, collagen‐induced arthritis (CIA) model, in Wistar albino rats, was used to elucidate the effect of EGCG on pathogenetic pathways in inflammatory arthritis. The leve...
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| Veröffentlicht in: | Biotechnology and applied biochemistry 2020-05, Vol.67 (3), p.317-322, Article bab.1860 |
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| creator | Karatas, Ahmet Dagli, Adile Ferda Orhan, Cemal Gencoglu, Hasan Ozgen, Metin Sahin, Nurhan Sahin, Kazim Koca, Suleyman Serdar |
| description | Epigallocatechin 3‐gallate (EGCG) is a polyphenol that has been shown to have antioxidant and anti‐inflammatory effects. In this study, collagen‐induced arthritis (CIA) model, in Wistar albino rats, was used to elucidate the effect of EGCG on pathogenetic pathways in inflammatory arthritis. The levels of serum TNF‐α, IL‐17, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx); the expression levels of tissue heme oxygenase‐1 (HO‐1) and nuclear factor erythroid 2‐related factor 2 (Nrf2); histopathologically, perisynovial inflammation and cartilage‐bone destruction were examined. In the sham group, serum TNF‐α, IL‐17, and MDA levels increased, while SOD, CAT, GPx levels, and the expressions of Nrf2 and HO‐1 decreased. On the other hand, in the EGCG administered groups, serum TNF‐α, IL‐17, and MDA levels improved, while SOD, CAT, GPx levels and the expressions of Nrf2 and HO‐1 increased. Moreover, histopathological analysis has shown that perisynovial inflammation and cartilage‐bone destruction decreased in the EGCG administered groups. These results suggest that EGCG has an antiarthritic effect by regulating the oxidative‐antioxidant balance and cytokine levels in the CIA model, which is a surrogate experimental model of rheumatoid arthritis.
EGCG applications, in experimental arthritis model, enhance the antioxidants enzyme levels and the expressions of Nrf‐2 and HO‐1. On the other hand, EGCG applications decrease the level of MDA, an oxidant, and the level of pro‐inflammatory cytokines. Moreover, EGCG ameliorates the clinical and histological findings of inflammatory arthritis. |
| doi_str_mv | 10.1002/bab.1860 |
| format | Article |
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EGCG applications, in experimental arthritis model, enhance the antioxidants enzyme levels and the expressions of Nrf‐2 and HO‐1. On the other hand, EGCG applications decrease the level of MDA, an oxidant, and the level of pro‐inflammatory cytokines. Moreover, EGCG ameliorates the clinical and histological findings of inflammatory arthritis.</description><identifier>ISSN: 0885-4513</identifier><identifier>EISSN: 1470-8744</identifier><identifier>DOI: 10.1002/bab.1860</identifier><identifier>PMID: 31746064</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject><![CDATA[Animal models ; Animals ; Antioxidants ; Arthritis ; Arthritis, Experimental - chemically induced ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - metabolism ; Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Cartilage ; Catalase ; Catechin - analogs & derivatives ; Catechin - pharmacology ; Collagen ; Collagen Type II ; collagen‐induced arthritis ; Cytokines ; Cytokines - antagonists & inhibitors ; Cytokines - biosynthesis ; Destruction ; Disease Models, Animal ; Epigallocatechin-3-gallate ; Female ; Glutathione ; Glutathione peroxidase ; Heme ; Heme Oxygenase (Decyclizing) - antagonists & inhibitors ; Heme Oxygenase (Decyclizing) - biosynthesis ; Inflammation ; Life Sciences & Biomedicine ; Malondialdehyde ; NF-E2-Related Factor 2 - antagonists & inhibitors ; NF-E2-Related Factor 2 - biosynthesis ; Oxygenase ; Peroxidase ; Rats ; Rats, Wistar ; Rheumatoid arthritis ; Science & Technology ; Superoxide dismutase ; Tumor necrosis factor]]></subject><ispartof>Biotechnology and applied biochemistry, 2020-05, Vol.67 (3), p.317-322, Article bab.1860</ispartof><rights>2019 International Union of Biochemistry and Molecular Biology, Inc.</rights><rights>2020 International Union of Biochemistry and Molecular Biology, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>29</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000555601200002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4150-a9a3069a250571f7dc16b0b216ffd6cb2ab89ed0c6c8318b2b06841bced3a303</citedby><cites>FETCH-LOGICAL-c4150-a9a3069a250571f7dc16b0b216ffd6cb2ab89ed0c6c8318b2b06841bced3a303</cites><orcidid>0000-0003-4995-430X ; 0000-0002-6725-4182 ; 0000-0003-4138-7689 ; 0000-0003-4077-4134 ; 0000-0001-9542-5244</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbab.1860$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbab.1860$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,28253,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31746064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karatas, Ahmet</creatorcontrib><creatorcontrib>Dagli, Adile Ferda</creatorcontrib><creatorcontrib>Orhan, Cemal</creatorcontrib><creatorcontrib>Gencoglu, Hasan</creatorcontrib><creatorcontrib>Ozgen, Metin</creatorcontrib><creatorcontrib>Sahin, Nurhan</creatorcontrib><creatorcontrib>Sahin, Kazim</creatorcontrib><creatorcontrib>Koca, Suleyman Serdar</creatorcontrib><title>Epigallocatechin 3‐gallate attenuates arthritis by regulating Nrf2, HO‐1, and cytokine levels in an experimental arthritis model</title><title>Biotechnology and applied biochemistry</title><addtitle>BIOTECHNOL APPL BIOC</addtitle><addtitle>Biotechnol Appl Biochem</addtitle><description>Epigallocatechin 3‐gallate (EGCG) is a polyphenol that has been shown to have antioxidant and anti‐inflammatory effects. In this study, collagen‐induced arthritis (CIA) model, in Wistar albino rats, was used to elucidate the effect of EGCG on pathogenetic pathways in inflammatory arthritis. The levels of serum TNF‐α, IL‐17, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx); the expression levels of tissue heme oxygenase‐1 (HO‐1) and nuclear factor erythroid 2‐related factor 2 (Nrf2); histopathologically, perisynovial inflammation and cartilage‐bone destruction were examined. In the sham group, serum TNF‐α, IL‐17, and MDA levels increased, while SOD, CAT, GPx levels, and the expressions of Nrf2 and HO‐1 decreased. On the other hand, in the EGCG administered groups, serum TNF‐α, IL‐17, and MDA levels improved, while SOD, CAT, GPx levels and the expressions of Nrf2 and HO‐1 increased. Moreover, histopathological analysis has shown that perisynovial inflammation and cartilage‐bone destruction decreased in the EGCG administered groups. These results suggest that EGCG has an antiarthritic effect by regulating the oxidative‐antioxidant balance and cytokine levels in the CIA model, which is a surrogate experimental model of rheumatoid arthritis.
EGCG applications, in experimental arthritis model, enhance the antioxidants enzyme levels and the expressions of Nrf‐2 and HO‐1. On the other hand, EGCG applications decrease the level of MDA, an oxidant, and the level of pro‐inflammatory cytokines. Moreover, EGCG ameliorates the clinical and histological findings of inflammatory arthritis.</description><subject>Animal models</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Arthritis</subject><subject>Arthritis, Experimental - chemically induced</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - metabolism</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biotechnology & Applied Microbiology</subject><subject>Cartilage</subject><subject>Catalase</subject><subject>Catechin - analogs & derivatives</subject><subject>Catechin - pharmacology</subject><subject>Collagen</subject><subject>Collagen Type II</subject><subject>collagen‐induced arthritis</subject><subject>Cytokines</subject><subject>Cytokines - antagonists & inhibitors</subject><subject>Cytokines - biosynthesis</subject><subject>Destruction</subject><subject>Disease Models, Animal</subject><subject>Epigallocatechin-3-gallate</subject><subject>Female</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Heme</subject><subject>Heme Oxygenase (Decyclizing) - antagonists & inhibitors</subject><subject>Heme Oxygenase (Decyclizing) - biosynthesis</subject><subject>Inflammation</subject><subject>Life Sciences & Biomedicine</subject><subject>Malondialdehyde</subject><subject>NF-E2-Related Factor 2 - antagonists & inhibitors</subject><subject>NF-E2-Related Factor 2 - biosynthesis</subject><subject>Oxygenase</subject><subject>Peroxidase</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rheumatoid arthritis</subject><subject>Science & Technology</subject><subject>Superoxide dismutase</subject><subject>Tumor necrosis factor</subject><issn>0885-4513</issn><issn>1470-8744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkcFuEzEQhi0EoqEg8QTIEhckumXs9XqdYxsVilTRS-8r2zubumzsYHuB3HrpnUfgWXgUngSHhIoLEieP7e__Z_QPIc8ZHDMA_sZoc8yUhAdkxkQLlWqFeEhmoFRTiYbVB-RJSjcAoFrFH5ODmrVCghQzcne2dks9jsHqjPbaeVr_vP22fSl3qnNGP5UqUR3zdXTZJWo2NOJyKoDzS_ohDvyInl8WFTui2vfUbnL46DzSET_jmKjzP75rT_HrGqNboc96_MttFXocn5JHgx4TPtufh-Tq7dnV4ry6uHz3fnFyUVnBGqj0XNcg55o30LRsaHvLpAHDmRyGXlrDtVFz7MFKq2qmDDcglWDGYl8XZX1IXu5s1zF8mjDl7iZM0ZeOHRflX8xbJQv1akfZGFKKOHTrMreOm45Bt427K3F327gL-mJvOJkV9vfgn3wL8HoHfEEThmQdeov3WFlI0zQSGC8V8EKr_6cXLpcNBL8Ik89FWu2lbsTNPyfuTk9Of0_-C6KhrUE</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Karatas, Ahmet</creator><creator>Dagli, Adile Ferda</creator><creator>Orhan, Cemal</creator><creator>Gencoglu, Hasan</creator><creator>Ozgen, Metin</creator><creator>Sahin, Nurhan</creator><creator>Sahin, Kazim</creator><creator>Koca, Suleyman Serdar</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TB</scope><scope>7TK</scope><scope>7U5</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>L7M</scope><scope>M7N</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-4995-430X</orcidid><orcidid>https://orcid.org/0000-0002-6725-4182</orcidid><orcidid>https://orcid.org/0000-0003-4138-7689</orcidid><orcidid>https://orcid.org/0000-0003-4077-4134</orcidid><orcidid>https://orcid.org/0000-0001-9542-5244</orcidid></search><sort><creationdate>202005</creationdate><title>Epigallocatechin 3‐gallate attenuates arthritis by regulating Nrf2, HO‐1, and cytokine levels in an experimental arthritis model</title><author>Karatas, Ahmet ; Dagli, Adile Ferda ; Orhan, Cemal ; Gencoglu, Hasan ; Ozgen, Metin ; Sahin, Nurhan ; Sahin, Kazim ; Koca, Suleyman Serdar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4150-a9a3069a250571f7dc16b0b216ffd6cb2ab89ed0c6c8318b2b06841bced3a303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Arthritis</topic><topic>Arthritis, Experimental - chemically induced</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - metabolism</topic><topic>Biochemistry & Molecular Biology</topic><topic>Biotechnology & Applied Microbiology</topic><topic>Cartilage</topic><topic>Catalase</topic><topic>Catechin - analogs & derivatives</topic><topic>Catechin - pharmacology</topic><topic>Collagen</topic><topic>Collagen Type II</topic><topic>collagen‐induced arthritis</topic><topic>Cytokines</topic><topic>Cytokines - antagonists & inhibitors</topic><topic>Cytokines - biosynthesis</topic><topic>Destruction</topic><topic>Disease Models, Animal</topic><topic>Epigallocatechin-3-gallate</topic><topic>Female</topic><topic>Glutathione</topic><topic>Glutathione peroxidase</topic><topic>Heme</topic><topic>Heme Oxygenase (Decyclizing) - antagonists & inhibitors</topic><topic>Heme Oxygenase (Decyclizing) - biosynthesis</topic><topic>Inflammation</topic><topic>Life Sciences & Biomedicine</topic><topic>Malondialdehyde</topic><topic>NF-E2-Related Factor 2 - antagonists & inhibitors</topic><topic>NF-E2-Related Factor 2 - biosynthesis</topic><topic>Oxygenase</topic><topic>Peroxidase</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rheumatoid arthritis</topic><topic>Science & Technology</topic><topic>Superoxide dismutase</topic><topic>Tumor necrosis factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karatas, Ahmet</creatorcontrib><creatorcontrib>Dagli, Adile Ferda</creatorcontrib><creatorcontrib>Orhan, Cemal</creatorcontrib><creatorcontrib>Gencoglu, Hasan</creatorcontrib><creatorcontrib>Ozgen, Metin</creatorcontrib><creatorcontrib>Sahin, Nurhan</creatorcontrib><creatorcontrib>Sahin, Kazim</creatorcontrib><creatorcontrib>Koca, Suleyman Serdar</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biotechnology and applied biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karatas, Ahmet</au><au>Dagli, Adile Ferda</au><au>Orhan, Cemal</au><au>Gencoglu, Hasan</au><au>Ozgen, Metin</au><au>Sahin, Nurhan</au><au>Sahin, Kazim</au><au>Koca, Suleyman Serdar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epigallocatechin 3‐gallate attenuates arthritis by regulating Nrf2, HO‐1, and cytokine levels in an experimental arthritis model</atitle><jtitle>Biotechnology and applied biochemistry</jtitle><stitle>BIOTECHNOL APPL BIOC</stitle><addtitle>Biotechnol Appl Biochem</addtitle><date>2020-05</date><risdate>2020</risdate><volume>67</volume><issue>3</issue><spage>317</spage><epage>322</epage><pages>317-322</pages><artnum>bab.1860</artnum><issn>0885-4513</issn><eissn>1470-8744</eissn><abstract>Epigallocatechin 3‐gallate (EGCG) is a polyphenol that has been shown to have antioxidant and anti‐inflammatory effects. In this study, collagen‐induced arthritis (CIA) model, in Wistar albino rats, was used to elucidate the effect of EGCG on pathogenetic pathways in inflammatory arthritis. The levels of serum TNF‐α, IL‐17, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx); the expression levels of tissue heme oxygenase‐1 (HO‐1) and nuclear factor erythroid 2‐related factor 2 (Nrf2); histopathologically, perisynovial inflammation and cartilage‐bone destruction were examined. In the sham group, serum TNF‐α, IL‐17, and MDA levels increased, while SOD, CAT, GPx levels, and the expressions of Nrf2 and HO‐1 decreased. On the other hand, in the EGCG administered groups, serum TNF‐α, IL‐17, and MDA levels improved, while SOD, CAT, GPx levels and the expressions of Nrf2 and HO‐1 increased. Moreover, histopathological analysis has shown that perisynovial inflammation and cartilage‐bone destruction decreased in the EGCG administered groups. These results suggest that EGCG has an antiarthritic effect by regulating the oxidative‐antioxidant balance and cytokine levels in the CIA model, which is a surrogate experimental model of rheumatoid arthritis.
EGCG applications, in experimental arthritis model, enhance the antioxidants enzyme levels and the expressions of Nrf‐2 and HO‐1. On the other hand, EGCG applications decrease the level of MDA, an oxidant, and the level of pro‐inflammatory cytokines. Moreover, EGCG ameliorates the clinical and histological findings of inflammatory arthritis.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>31746064</pmid><doi>10.1002/bab.1860</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4995-430X</orcidid><orcidid>https://orcid.org/0000-0002-6725-4182</orcidid><orcidid>https://orcid.org/0000-0003-4138-7689</orcidid><orcidid>https://orcid.org/0000-0003-4077-4134</orcidid><orcidid>https://orcid.org/0000-0001-9542-5244</orcidid></addata></record> |
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| subjects | Animal models Animals Antioxidants Arthritis Arthritis, Experimental - chemically induced Arthritis, Experimental - drug therapy Arthritis, Experimental - metabolism Biochemistry & Molecular Biology Biotechnology & Applied Microbiology Cartilage Catalase Catechin - analogs & derivatives Catechin - pharmacology Collagen Collagen Type II collagen‐induced arthritis Cytokines Cytokines - antagonists & inhibitors Cytokines - biosynthesis Destruction Disease Models, Animal Epigallocatechin-3-gallate Female Glutathione Glutathione peroxidase Heme Heme Oxygenase (Decyclizing) - antagonists & inhibitors Heme Oxygenase (Decyclizing) - biosynthesis Inflammation Life Sciences & Biomedicine Malondialdehyde NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - biosynthesis Oxygenase Peroxidase Rats Rats, Wistar Rheumatoid arthritis Science & Technology Superoxide dismutase Tumor necrosis factor |
| title | Epigallocatechin 3‐gallate attenuates arthritis by regulating Nrf2, HO‐1, and cytokine levels in an experimental arthritis model |
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