Sodium, Magnesium, Calcium, Manganese, Iron, Copper, and Zinc in Serums of Beta Thalassemia Major Patients
Thalassemia major is the most severe form of thalassemia and occurs with the impaired synthesis of β-globin which causes the accumulation of unpaired alpha globin chain. Patients with beta thalassemia major can only survive with periodically safe blood transfusions leading to the accumulation of iro...
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| Veröffentlicht in: | Biological trace element research 2021-03, Vol.199 (3), p.888-894 |
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| creator | Şahin, Ayşe Er, Elif Öztürk Öz, Ersoy Yıldırmak, Zeynep Yıldız Bakırdere, Sezgin |
| description | Thalassemia major is the most severe form of thalassemia and occurs with the impaired synthesis of β-globin which causes the accumulation of unpaired alpha globin chain. Patients with beta thalassemia major can only survive with periodically safe blood transfusions leading to the accumulation of iron in the bloods of patients, and this causes several endocrinopathies. Although iron overload in thalassemic patients has been extensively studied, there is little information about the levels of other trace elements. The aim of this study was to investigate the differences of serum concentrations of sodium, magnesium, calcium, manganese, iron, copper, and zinc for patients with major β-thalassemia. Concentration of elements was determined by inductively coupled plasma-mass spectrometry system. The statistical difference between the elemental concentrations of the patient and control groups was found by the Mann-Whitney
U
test. In addition, the relationship between concentrations of the measured elements for each group was determined by the Spearman correlation test. The results revealed that iron, zinc, magnesium, and manganese serum levels of thalassemic patients were significantly higher than the control group while calcium concentration was statistically lower than the control group. There was no significant difference observed for copper and sodium levels of patients when compared to the healthy control group. |
| doi_str_mv | 10.1007/s12011-020-02217-5 |
| format | Article |
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U
test. In addition, the relationship between concentrations of the measured elements for each group was determined by the Spearman correlation test. The results revealed that iron, zinc, magnesium, and manganese serum levels of thalassemic patients were significantly higher than the control group while calcium concentration was statistically lower than the control group. There was no significant difference observed for copper and sodium levels of patients when compared to the healthy control group.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-020-02217-5</identifier><identifier>PMID: 32462603</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Accumulation ; Biochemistry ; Biochemistry & Molecular Biology ; Biomedical and Life Sciences ; Biotechnology ; Blood transfusion ; Calcium ; Control ; Copper ; Endocrine disorders ; Endocrinology & Metabolism ; Inductively coupled plasma mass spectrometry ; Iron ; Life Sciences ; Life Sciences & Biomedicine ; Magnesium ; Manganese ; Mass spectrometry ; Mass spectroscopy ; Nutrition ; Oncology ; Science & Technology ; Serum ; Serum levels ; Sodium ; Survival ; Thalassemia ; Trace elements ; Zinc</subject><ispartof>Biological trace element research, 2021-03, Vol.199 (3), p.888-894</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>10</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000553929800001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c375t-1bee21430a2f28992b4e3a8e7e08465a5374509f83877e4aa8b59a314d1d5b7a3</citedby><cites>FETCH-LOGICAL-c375t-1bee21430a2f28992b4e3a8e7e08465a5374509f83877e4aa8b59a314d1d5b7a3</cites><orcidid>0000-0001-7231-2394 ; 0000-0002-4877-2662</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-020-02217-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-020-02217-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,39265,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32462603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Şahin, Ayşe</creatorcontrib><creatorcontrib>Er, Elif Öztürk</creatorcontrib><creatorcontrib>Öz, Ersoy</creatorcontrib><creatorcontrib>Yıldırmak, Zeynep Yıldız</creatorcontrib><creatorcontrib>Bakırdere, Sezgin</creatorcontrib><title>Sodium, Magnesium, Calcium, Manganese, Iron, Copper, and Zinc in Serums of Beta Thalassemia Major Patients</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>BIOL TRACE ELEM RES</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Thalassemia major is the most severe form of thalassemia and occurs with the impaired synthesis of β-globin which causes the accumulation of unpaired alpha globin chain. Patients with beta thalassemia major can only survive with periodically safe blood transfusions leading to the accumulation of iron in the bloods of patients, and this causes several endocrinopathies. Although iron overload in thalassemic patients has been extensively studied, there is little information about the levels of other trace elements. The aim of this study was to investigate the differences of serum concentrations of sodium, magnesium, calcium, manganese, iron, copper, and zinc for patients with major β-thalassemia. Concentration of elements was determined by inductively coupled plasma-mass spectrometry system. The statistical difference between the elemental concentrations of the patient and control groups was found by the Mann-Whitney
U
test. In addition, the relationship between concentrations of the measured elements for each group was determined by the Spearman correlation test. The results revealed that iron, zinc, magnesium, and manganese serum levels of thalassemic patients were significantly higher than the control group while calcium concentration was statistically lower than the control group. There was no significant difference observed for copper and sodium levels of patients when compared to the healthy control group.</description><subject>Accumulation</subject><subject>Biochemistry</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood transfusion</subject><subject>Calcium</subject><subject>Control</subject><subject>Copper</subject><subject>Endocrine disorders</subject><subject>Endocrinology & Metabolism</subject><subject>Inductively coupled plasma mass spectrometry</subject><subject>Iron</subject><subject>Life Sciences</subject><subject>Life Sciences & Biomedicine</subject><subject>Magnesium</subject><subject>Manganese</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Science & Technology</subject><subject>Serum</subject><subject>Serum 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Sezgin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sodium, Magnesium, Calcium, Manganese, Iron, Copper, and Zinc in Serums of Beta Thalassemia Major Patients</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><stitle>BIOL TRACE ELEM RES</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>199</volume><issue>3</issue><spage>888</spage><epage>894</epage><pages>888-894</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Thalassemia major is the most severe form of thalassemia and occurs with the impaired synthesis of β-globin which causes the accumulation of unpaired alpha globin chain. Patients with beta thalassemia major can only survive with periodically safe blood transfusions leading to the accumulation of iron in the bloods of patients, and this causes several endocrinopathies. Although iron overload in thalassemic patients has been extensively studied, there is little information about the levels of other trace elements. The aim of this study was to investigate the differences of serum concentrations of sodium, magnesium, calcium, manganese, iron, copper, and zinc for patients with major β-thalassemia. Concentration of elements was determined by inductively coupled plasma-mass spectrometry system. The statistical difference between the elemental concentrations of the patient and control groups was found by the Mann-Whitney
U
test. In addition, the relationship between concentrations of the measured elements for each group was determined by the Spearman correlation test. The results revealed that iron, zinc, magnesium, and manganese serum levels of thalassemic patients were significantly higher than the control group while calcium concentration was statistically lower than the control group. There was no significant difference observed for copper and sodium levels of patients when compared to the healthy control group.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32462603</pmid><doi>10.1007/s12011-020-02217-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7231-2394</orcidid><orcidid>https://orcid.org/0000-0002-4877-2662</orcidid></addata></record> |
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| subjects | Accumulation Biochemistry Biochemistry & Molecular Biology Biomedical and Life Sciences Biotechnology Blood transfusion Calcium Control Copper Endocrine disorders Endocrinology & Metabolism Inductively coupled plasma mass spectrometry Iron Life Sciences Life Sciences & Biomedicine Magnesium Manganese Mass spectrometry Mass spectroscopy Nutrition Oncology Science & Technology Serum Serum levels Sodium Survival Thalassemia Trace elements Zinc |
| title | Sodium, Magnesium, Calcium, Manganese, Iron, Copper, and Zinc in Serums of Beta Thalassemia Major Patients |
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