Sodium, Magnesium, Calcium, Manganese, Iron, Copper, and Zinc in Serums of Beta Thalassemia Major Patients

Thalassemia major is the most severe form of thalassemia and occurs with the impaired synthesis of β-globin which causes the accumulation of unpaired alpha globin chain. Patients with beta thalassemia major can only survive with periodically safe blood transfusions leading to the accumulation of iro...

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Veröffentlicht in:Biological trace element research 2021-03, Vol.199 (3), p.888-894
Hauptverfasser: Şahin, Ayşe, Er, Elif Öztürk, Öz, Ersoy, Yıldırmak, Zeynep Yıldız, Bakırdere, Sezgin
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container_title Biological trace element research
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creator Şahin, Ayşe
Er, Elif Öztürk
Öz, Ersoy
Yıldırmak, Zeynep Yıldız
Bakırdere, Sezgin
description Thalassemia major is the most severe form of thalassemia and occurs with the impaired synthesis of β-globin which causes the accumulation of unpaired alpha globin chain. Patients with beta thalassemia major can only survive with periodically safe blood transfusions leading to the accumulation of iron in the bloods of patients, and this causes several endocrinopathies. Although iron overload in thalassemic patients has been extensively studied, there is little information about the levels of other trace elements. The aim of this study was to investigate the differences of serum concentrations of sodium, magnesium, calcium, manganese, iron, copper, and zinc for patients with major β-thalassemia. Concentration of elements was determined by inductively coupled plasma-mass spectrometry system. The statistical difference between the elemental concentrations of the patient and control groups was found by the Mann-Whitney U test. In addition, the relationship between concentrations of the measured elements for each group was determined by the Spearman correlation test. The results revealed that iron, zinc, magnesium, and manganese serum levels of thalassemic patients were significantly higher than the control group while calcium concentration was statistically lower than the control group. There was no significant difference observed for copper and sodium levels of patients when compared to the healthy control group.
doi_str_mv 10.1007/s12011-020-02217-5
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subjects Accumulation
Biochemistry
Biochemistry & Molecular Biology
Biomedical and Life Sciences
Biotechnology
Blood transfusion
Calcium
Control
Copper
Endocrine disorders
Endocrinology & Metabolism
Inductively coupled plasma mass spectrometry
Iron
Life Sciences
Life Sciences & Biomedicine
Magnesium
Manganese
Mass spectrometry
Mass spectroscopy
Nutrition
Oncology
Science & Technology
Serum
Serum levels
Sodium
Survival
Thalassemia
Trace elements
Zinc
title Sodium, Magnesium, Calcium, Manganese, Iron, Copper, and Zinc in Serums of Beta Thalassemia Major Patients
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