Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction

T cells undergo metabolic rewiring to meet their bioenergetic, biosynthetic and redox demands following antigen stimulation. To fulfil these needs, effector T cells must adapt to fluctuations in environmental nutrient levels at sites of infection and inflammation. Here, we show that effector T cells...

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Veröffentlicht in:	Nature metabolism 2020-07, Vol.2 (7), p.635-647
Hauptverfasser:	Wang, Tingting, Gnanaprakasam, J. N. Rashida, Chen, Xuyong, Kang, Siwen, Xu, Xuequn, Sun, Hua, Liu, Lingling, Rodgers, Hayley, Miller, Ethan, Cassel, Teresa A., Sun, Qiushi, Vicente-Muñoz, Sara, Warmoes, Marc O., Lin, Penghui, Piedra-Quintero, Zayda Lizbeth, Guerau-de-Arellano, Mireia, Cassady, Kevin A., Zheng, Song Guo, Yang, Jun, Lane, Andrew N., Song, Xiaotong, Fan, Teresa W.-M., Wang, Ruoning
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/21 13/31 13/89 631/250/1619/554/1834/1269 631/443/319/320 631/67 631/92/1643 64 64/110 64/60 82 Adoptive Transfer Animals Biomedical and Life Sciences Carbon - metabolism CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Endocrinology & Metabolism Glucose - deficiency HeLa Cells Humans Hypoxanthine - metabolism Inflammation - metabolism Inosine - metabolism Life Sciences Life Sciences & Biomedicine Mice Mice, Inbred C57BL Nutrients Purine-Nucleoside Phosphorylase - metabolism Ribose - metabolism Science & Technology
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