Nrf2 Antioxidative System is Involved in Cytochrome P450 Gene Expression and Activity: A Delay in Pentobarbital Metabolism in Nrf2-Deficient Mice

NF-E2–related factor 2 (Nrf2) is a transcriptional regulator of biologic defense proteins, such as antioxidant proteins and phase II detoxification enzymes. Cytochrome P450 (P450) enzymes have been shown to regulate phase I metabolism of various drugs and are partially regulated by Nrf2; however, th...

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Veröffentlicht in:	Drug metabolism and disposition 2020-08, Vol.48 (8), p.673-680
Hauptverfasser:	Ashino, Takashi, Yamamoto, Masayuki, Numazawa, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
Online-Zugang:	Volltext
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