Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease

In 2016, a new interferon-gamma release assay, QuantiFERON-TB Gold Plus, was introduced. We conducted a cross-sectional multicenter study, involving 158 children and adolescents with tuberculosis disease. The overall sensitivity of the assay was 82.9% (IQR 77.0%-88.8%), indicating that in children t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pediatrics 2020-08, Vol.223, p.212-215.e1
Hauptverfasser:	Soler-Garcia, Aleix, Gamell, Anna, Santiago, Begoña, Monsonís, Manuel, Calvo, Cristina, Cobo, Elvira, Colino, Elena, Espiau, María, Guerrero-Laleona, Carmelo, Lobato, Zulema, Martín-Nalda, Andrea, Pérez-Gorricho, Beatriz, Perez-Porcuna, Tomas M., Piqueras, Ana Isabel, Rodríguez-Molino, Paula, Ruiz, Marta, Soriano-Arandes, Antoni, Valmanya, Teresa, Tebruegge, Marc, Noguera-Julian, Antoni, Gómez-Pastrana, David, Montero, Maria, Peromingo, Estrella, Bustillo, Matilde, Moliner, Elisenda, Fenoy, Marina, Velásquez, Marta, Soler, Maria Queralt, GARCÍA, Lourdes, Calavia, Olga, Rius, Neus, Pascual, Maria Teresa, Soler-Palacín, Pere, Tórtola, Teresa, Lillo, Miguel, Dapena, Marta, López-Medina, Eva María, Santos, Maria del Mar, Hernández, Ángel, Hernández-Sanpelayo, Teresa, Tagarro, Alfredo, Méndez, Ana, Mellado, María José, Baquero-Artigao, Fernando, Sainz, Talía, García-Hortelano, Miluca, Álvarez, Javier, Villalobos, Enrique, García-García, María Luz, Garrote, María Isabel, Korta Murua, José Javier, Gundín, Nerea Azurmendi, Sánchez-Torrent, Laia, Velasco-Arnaiz, Eneritz, Fortuny, Clàudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Child Child, Preschool diagnosis Female Follow-Up Studies Humans interferon-gamma release assay Interferon-gamma Release Tests - methods Life Sciences & Biomedicine Male Mycobacterium tuberculosis - isolation & purification Pediatrics Retrospective Studies Science & Technology sensitivity Tuberculin Test - methods Tuberculosis - diagnosis Tuberculosis - microbiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In 2016, a new interferon-gamma release assay, QuantiFERON-TB Gold Plus, was introduced. We conducted a cross-sectional multicenter study, involving 158 children and adolescents with tuberculosis disease. The overall sensitivity of the assay was 82.9% (IQR 77.0%-88.8%), indicating that in children this test does not have higher sensitivity than previous generation interferon-gamma release assays.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2020.02.025