New insights into the mechanisms behind mechanical itch
Gentle tactile stimuli, such as insects crawling on the skin, can cause itching sensation called mechanical itch. Recent studies have begun to shed light on the neural mechanisms of mechanical itch. Interestingly, the neural pathway for mechanical itch is apparently different from that for chemical...
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| Veröffentlicht in: | Experimental dermatology 2020-08, Vol.29 (8), p.680-686 |
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| container_title | Experimental dermatology |
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| creator | Sakai, Kent Akiyama, Tasuku |
| description | Gentle tactile stimuli, such as insects crawling on the skin, can cause itching sensation called mechanical itch. Recent studies have begun to shed light on the neural mechanisms of mechanical itch. Interestingly, the neural pathway for mechanical itch is apparently different from that for chemical itch triggered by the activation of pruriceptors with various mediators. Mechanical itch dysesthesia is frequently seen in patients with chronic itch. Mechanisms of this dysesthesia are plausibly involved in central sensitization. In this review, we summarize the current knowledge of mechanical itch under normal and pathological conditions. |
| doi_str_mv | 10.1111/exd.14143 |
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In this review, we summarize the current knowledge of mechanical itch under normal and pathological conditions.</description><subject>chemical itch</subject><subject>Dermatology</subject><subject>disinhibition</subject><subject>GRPR</subject><subject>Life Sciences & Biomedicine</subject><subject>LTMR</subject><subject>Pruritus</subject><subject>Science & Technology</subject><subject>sensitization</subject><subject>Tactile stimuli</subject><issn>0906-6705</issn><issn>1600-0625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqNkc1O3TAQha2KqlxoF32DSN1QocA4_ks2SNUtUCRENyy6sxxnQowSm8ZOKW9f03uLVCQkvPFo5pujYx9CPlI4ovkc4-_uiHLK2RuyohKgBFmJHbKCBmQpFYhdshfjLQBVTIl3ZJdVsqIM2IqoK7wvnI_uZkgxFykUacBiQjsY7-IUixYH57t_HWvGwiU7vCdvezNG_LC998n12en1-lt5-f38Yv3lsrS8AlZ2FTdGtspaVZuG88ZysByB112v2k5VgCxPWmHqninJpGmRKm6k6gTNrX1yspG9W9oJO4s-zWbUd7ObzPygg3H6_4l3g74Jv7TitQLJs8DBVmAOPxeMSU8uWhxH4zEsUVfZJhWiZk1GPz1Db8My-_y6TD3-rgIuMvV5Q9k5xDhj_2SGgn5MQ-c09N80Mnu4Ye-xDX20Dr3FJx4ABG9q2YhcAc10_Xp67ZJJLvh1WHzKq8fbVTfiw8uO9OmPrxtrfwA9zaom</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Sakai, Kent</creator><creator>Akiyama, Tasuku</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7155-4228</orcidid><orcidid>https://orcid.org/0000-0002-8247-4036</orcidid></search><sort><creationdate>202008</creationdate><title>New insights into the mechanisms behind mechanical itch</title><author>Sakai, Kent ; Akiyama, Tasuku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4203-d24aa6b7cc78a9449c40c4e048df7bd720e378ab5a8f37636abe174a67d518f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>chemical itch</topic><topic>Dermatology</topic><topic>disinhibition</topic><topic>GRPR</topic><topic>Life Sciences & Biomedicine</topic><topic>LTMR</topic><topic>Pruritus</topic><topic>Science & Technology</topic><topic>sensitization</topic><topic>Tactile stimuli</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakai, Kent</creatorcontrib><creatorcontrib>Akiyama, Tasuku</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakai, Kent</au><au>Akiyama, Tasuku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New insights into the mechanisms behind mechanical itch</atitle><jtitle>Experimental dermatology</jtitle><stitle>EXP DERMATOL</stitle><date>2020-08</date><risdate>2020</risdate><volume>29</volume><issue>8</issue><spage>680</spage><epage>686</epage><pages>680-686</pages><issn>0906-6705</issn><eissn>1600-0625</eissn><abstract>Gentle tactile stimuli, such as insects crawling on the skin, can cause itching sensation called mechanical itch. 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| language | eng |
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| source | Access via Wiley Online Library |
| subjects | chemical itch Dermatology disinhibition GRPR Life Sciences & Biomedicine LTMR Pruritus Science & Technology sensitization Tactile stimuli |
| title | New insights into the mechanisms behind mechanical itch |
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