A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development

Multiple genetic factors related to autism spectrum disorder (ASD) have been identified, but the biological mechanisms remain obscure. Timothy syndrome (TS), associated with syndromic ASD, is caused by a gain‐of‐function mutation, G406R, in the pore‐forming subunit of L‐type Ca2+ channels, Cav1.2. I...

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Veröffentlicht in:	FEBS open bio 2020-08, Vol.10 (8), p.1436-1446
Hauptverfasser:	Horigane, Shin‐ichiro, Ozawa, Yukihiro, Zhang, Jun, Todoroki, Hiroe, Miao, Pan, Haijima, Asahi, Yanagawa, Yuchio, Ueda, Shuhei, Nakamura, Shigeo, Kakeyama, Masaki, Takemoto‐Kimura, Sayaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Autism autism spectrum disorder Autistic Disorder - metabolism Automation Autosomal dominant inheritance Behavior Behavior, Animal Biochemistry & Molecular Biology Brain Calcium channels Calcium channels (voltage-gated) Competition Cortex (somatosensory) Disease Models, Animal Embryogenesis Flexibility Genetic factors IntelliCage Laboratories Life Sciences & Biomedicine Long QT Syndrome - metabolism L‐type Ca2+ channels Mice Mice, Congenic Mice, Inbred C57BL Mice, Transgenic Mutation Neocortex neural circuit formation Neurogenesis Neurons Phenotyping Science & Technology social competitive dominance Social Dominance Social interactions Syndactyly - metabolism Timothy syndrome
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