The secondary‐structured DNA‐binding activity of Dna2 endonuclease/helicase is critical to cell growth under replication stress

Dna2 can efficiently process 5′ flaps containing DNA secondary structure using coordinated action of the three biochemical activities: the N‐terminally encoded DNA‐binding activity and the C‐terminally encoded endonuclease and helicase activities. In this study, we investigated the cross talk among...

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Veröffentlicht in:	The FEBS journal 2021-02, Vol.288 (4), p.1224-1242
Hauptverfasser:	Park, Soyeong, Karatayeva, Nargis, Demin, Annie Albert, Munashingha, Palinda Ruvan, Seo, Yeon‐Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alleles Amino acids Binding Biochemistry & Molecular Biology checkpoint control Crosstalk Defects Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA helicase DNA replication DNA secondary structure DNA structure Dna2 DNA‐binding protein Domains Endonuclease Holliday junctions Intermediates Life Sciences & Biomedicine Mutants Original Phenotypes Protein structure Replication Residues Science & Technology Secondary structure Site-directed mutagenesis Substrates
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