Randomized Double-Blind Controlled Trial on the Effect of Proteins with Different Tryptophan/Large Neutral Amino Acid Ratios on Sleep in Adolescents: The PROTMORPHEUS Study
Disturbed sleep is common in adolescents. Ingested nutrients help regulate the internal clock and influence sleep quality. The purpose of this clinical trial is to assess the effect of protein tryptophan (Trp)/large neutral amino acids (LNAAs) ratio on sleep and circadian rhythm. Ingested Trp is inv...
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| Veröffentlicht in: | Nutrients 2020-06, Vol.12 (6), p.1885-17, Article 1885 |
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| creator | Saidi, Oussama Rochette, Emmanuelle Dore, Eric Maso, Freddy Raoux, Julien Andrieux, Fabien Fantini, Maria Livia Merlin, Etienne Pereira, Bruno Walrand, Stephane Duche, Pascale |
| description | Disturbed sleep is common in adolescents. Ingested nutrients help regulate the internal clock and influence sleep quality. The purpose of this clinical trial is to assess the effect of protein tryptophan (Trp)/large neutral amino acids (LNAAs) ratio on sleep and circadian rhythm. Ingested Trp is involved in the regulation of the sleep/wake cycle and improvement of sleep quality. Since Trp transport through the blood-brain barrier is competing with LNAAs, protein with higher Trp/LNAAs were expected to increase sleep efficiency. This randomized double-blind controlled trial will enroll two samples of male adolescents predisposed to sleep disturbances: elite rugby players (n = 24) and youths with obesity (n = 24). They will take part randomly in three sessions each held over a week. They will undergo a washout period, when dietary intake will be calibrated (three days), followed by an intervention period (three days), when their diet will be supplemented with three proteins with different Trp/LNAAs ratios. Physical, cognitive, dietary intake, appetite, and sleepiness evaluations will be made on the last day of each session. The primary outcome is sleep efficiency measured through in-home electroencephalogram recordings. Secondary outcomes include sleep staging, circadian phase, and sleep-, food intake-, metabolism-, and inflammation-related biochemical markers. A fuller understanding of the effect of protein Trp/LNAAs ratio on sleep could help in developing nutritional strategies addressing sleep disturbances. |
| doi_str_mv | 10.3390/nu12061885 |
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Ingested nutrients help regulate the internal clock and influence sleep quality. The purpose of this clinical trial is to assess the effect of protein tryptophan (Trp)/large neutral amino acids (LNAAs) ratio on sleep and circadian rhythm. Ingested Trp is involved in the regulation of the sleep/wake cycle and improvement of sleep quality. Since Trp transport through the blood-brain barrier is competing with LNAAs, protein with higher Trp/LNAAs were expected to increase sleep efficiency. This randomized double-blind controlled trial will enroll two samples of male adolescents predisposed to sleep disturbances: elite rugby players (n = 24) and youths with obesity (n = 24). They will take part randomly in three sessions each held over a week. They will undergo a washout period, when dietary intake will be calibrated (three days), followed by an intervention period (three days), when their diet will be supplemented with three proteins with different Trp/LNAAs ratios. Physical, cognitive, dietary intake, appetite, and sleepiness evaluations will be made on the last day of each session. The primary outcome is sleep efficiency measured through in-home electroencephalogram recordings. Secondary outcomes include sleep staging, circadian phase, and sleep-, food intake-, metabolism-, and inflammation-related biochemical markers. A fuller understanding of the effect of protein Trp/LNAAs ratio on sleep could help in developing nutritional strategies addressing sleep disturbances.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12061885</identifier><identifier>PMID: 32599773</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject><![CDATA[Adolescent ; Adolescents ; Amino acids ; Amino Acids, Neutral - administration & dosage ; Amino Acids, Neutral - pharmacology ; Athletes ; Biochemical markers ; Biosynthesis ; Blood-brain barrier ; Brain research ; Child development ; Circadian Rhythm ; Circadian rhythms ; Clinical trials ; Dietary intake ; Dietary Proteins - administration & dosage ; Dietary Proteins - chemistry ; Dietary Proteins - pharmacology ; Disturbances ; DLMO ; Double-Blind Method ; Double-blind studies ; EEG ; Efficiency ; Electroencephalography ; Food intake ; Human health and pathology ; Humans ; Immunology ; Life Sciences ; Life Sciences & Biomedicine ; Male ; Metabolism ; Nutrients ; nutrition ; Nutrition & Dietetics ; Obesity ; Pediatric Obesity - metabolism ; Pediatrics ; Physiology ; Proteins ; Questionnaires ; Randomization ; Rugby ; Science & Technology ; Sleep ; Sleep - drug effects ; Sleep and wakefulness ; Sleepiness ; slow wave sleep ; Teenagers ; Tryptophan ; Tryptophan - administration & dosage ; Tryptophan - pharmacology ; Weight control ; youth]]></subject><ispartof>Nutrients, 2020-06, Vol.12 (6), p.1885-17, Article 1885</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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Ingested nutrients help regulate the internal clock and influence sleep quality. The purpose of this clinical trial is to assess the effect of protein tryptophan (Trp)/large neutral amino acids (LNAAs) ratio on sleep and circadian rhythm. Ingested Trp is involved in the regulation of the sleep/wake cycle and improvement of sleep quality. Since Trp transport through the blood-brain barrier is competing with LNAAs, protein with higher Trp/LNAAs were expected to increase sleep efficiency. This randomized double-blind controlled trial will enroll two samples of male adolescents predisposed to sleep disturbances: elite rugby players (n = 24) and youths with obesity (n = 24). They will take part randomly in three sessions each held over a week. They will undergo a washout period, when dietary intake will be calibrated (three days), followed by an intervention period (three days), when their diet will be supplemented with three proteins with different Trp/LNAAs ratios. Physical, cognitive, dietary intake, appetite, and sleepiness evaluations will be made on the last day of each session. The primary outcome is sleep efficiency measured through in-home electroencephalogram recordings. Secondary outcomes include sleep staging, circadian phase, and sleep-, food intake-, metabolism-, and inflammation-related biochemical markers. 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| recordid | cdi_webofscience_primary_000549193800001 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; PubMed Central; Web of Science - Social Sciences Citation Index – 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Adolescent Adolescents Amino acids Amino Acids, Neutral - administration & dosage Amino Acids, Neutral - pharmacology Athletes Biochemical markers Biosynthesis Blood-brain barrier Brain research Child development Circadian Rhythm Circadian rhythms Clinical trials Dietary intake Dietary Proteins - administration & dosage Dietary Proteins - chemistry Dietary Proteins - pharmacology Disturbances DLMO Double-Blind Method Double-blind studies EEG Efficiency Electroencephalography Food intake Human health and pathology Humans Immunology Life Sciences Life Sciences & Biomedicine Male Metabolism Nutrients nutrition Nutrition & Dietetics Obesity Pediatric Obesity - metabolism Pediatrics Physiology Proteins Questionnaires Randomization Rugby Science & Technology Sleep Sleep - drug effects Sleep and wakefulness Sleepiness slow wave sleep Teenagers Tryptophan Tryptophan - administration & dosage Tryptophan - pharmacology Weight control youth |
| title | Randomized Double-Blind Controlled Trial on the Effect of Proteins with Different Tryptophan/Large Neutral Amino Acid Ratios on Sleep in Adolescents: The PROTMORPHEUS Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T05%3A23%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Randomized%20Double-Blind%20Controlled%20Trial%20on%20the%20Effect%20of%20Proteins%20with%20Different%20Tryptophan/Large%20Neutral%20Amino%20Acid%20Ratios%20on%20Sleep%20in%20Adolescents:%20The%20PROTMORPHEUS%20Study&rft.jtitle=Nutrients&rft.au=Saidi,%20Oussama&rft.date=2020-06-24&rft.volume=12&rft.issue=6&rft.spage=1885&rft.epage=17&rft.pages=1885-17&rft.artnum=1885&rft.issn=2072-6643&rft.eissn=2072-6643&rft_id=info:doi/10.3390/nu12061885&rft_dat=%3Cproquest_webof%3E2419087571%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2417948927&rft_id=info:pmid/32599773&rft_doaj_id=oai_doaj_org_article_ae360e8542a248e090363ff51237b116&rfr_iscdi=true |