Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian brain. In clinical settings, recombinant EPO treatment has revealed a remarkable improvement of cognition, but underlying mechanisms have remained obscure. Here, we show with a novel line of reporter mice tha...

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Veröffentlicht in:	Nature communications 2020-03, Vol.11 (1), p.1313-12, Article 1313
Hauptverfasser:	Wakhloo, Debia, Scharkowski, Franziska, Curto, Yasmina, Javed Butt, Umer, Bansal, Vikas, Steixner-Kumar, Agnes A., Wüstefeld, Liane, Rajput, Ashish, Arinrad, Sahab, Zillmann, Matthias R., Seelbach, Anna, Hassouna, Imam, Schneider, Katharina, Qadir Ibrahim, Abdul, Werner, Hauke B., Martens, Henrik, Miskowiak, Kamilla, Wojcik, Sonja M., Bonn, Stefan, Nacher, Juan, Nave, Klaus-Armin, Ehrenreich, Hannelore
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/19 38/91 631/378/2649 631/378/87 64/110 64/60 82/1 Animals Automotive wheels Brain Brain - metabolism Brain - physiopathology Cell Differentiation - drug effects Cognition Cognition & reasoning Cognition - drug effects Cognitive ability Cognitive tasks Dendritic plasticity Dendritic spines Dendritic Spines - drug effects Dendritic Spines - metabolism Drift Erythropoietin Erythropoietin - metabolism Erythropoietin - pharmacology Erythropoietin receptors Female Functional plasticity Gene Deletion Gene expression Hematopoiesis Hippocampal plasticity Hippocampus Humanities and Social Sciences Humans Hypoxia Hypoxia - metabolism Hypoxia - physiopathology Male Mice, Inbred C57BL Models, Neurological Motor Activity - drug effects multidisciplinary Neural networks Neurogenesis Neurogenesis - drug effects Neuronal Plasticity - drug effects Neurons Neuroplasticity Paracrine signalling Physical Conditioning, Animal Physical Endurance - drug effects Proto-Oncogene Proteins c-fos - metabolism Pyramidal cells Pyramidal Cells - drug effects Pyramidal Cells - metabolism Receptors, Erythropoietin - metabolism Respiration Science Science (multidisciplinary) Spine Transcriptome - drug effects Transcriptome - genetics
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