Comparison of the Effects of Antidepressants with Different Mechanisms of Action on Efficacy, Cognitive Functions and Side Effects
Objective: The aim of this study was to compare the effects of the agomelatine and selective serotonin reuptake inhibitors (SSRIs) on symptoms of depression, cognitive functions, impulsiveness, suicidal tendency, sleep pattern and side effects. Method: This study enrolled patients with depression st...
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| Veröffentlicht in: | Türk psikiyatri dergisi 2020, Vol.31 (2), p.90-98 |
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| creator | Erdogan, Cigdem Ozdemir Rezaki, Hatice Kocak, Orhan Murat Buturak, Sadiye Visal |
| description | Objective: The aim of this study was to compare the effects of the agomelatine and selective serotonin reuptake inhibitors (SSRIs) on symptoms of depression, cognitive functions, impulsiveness, suicidal tendency, sleep pattern and side effects.
Method: This study enrolled patients with depression started on SSRIs (n=30) or agomelatine (n=30) on an outpatient basis. All patients were evaluated with SCID-I and the Sociodemographic Questionnaire on the first day of the treatment. In order to assess the side effects of the treatments, the patients were ass ssed at the first and the fourth weeks with Hamilton Depression Scale (HAM-D), the Suicide Probability Scale (SPS), the UPSS Impulsive Behaviour Scale, the Epworth Sleepiness Scale (ESS), the UKU Side Effect Rating Scale, and the Stroop Test and the Trail Making Test for cognitive functions.
Results: Patients on SSRIs showed better treatment response and remission rates at the end of the first month. Improvement in cognitive functions correlated with the decrease in depressive symptoms, but no difference was observed between the groups with respect to the improvement of the cognitive functions. SSRIs caused more autonomic and sexual side effects compared to agomelatine. Differences were not observed between the effects of the two medications on impulsivity, sleep pattern and suicidal tendency.
Conclusion: In conclusion, treatment with SSRIs was significantly more associated with improvement in the clinical symptoms. Sexual side effects were more prevalent with SSRIs, but the effect on cognitive functions did not differ from agomelatine Despite the distinct, promising mechanism of action, agomelatine was not as effective as the SSRIs for the treatment of depression. |
| doi_str_mv | 10.5080/u23704 |
| format | Article |
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Method: This study enrolled patients with depression started on SSRIs (n=30) or agomelatine (n=30) on an outpatient basis. All patients were evaluated with SCID-I and the Sociodemographic Questionnaire on the first day of the treatment. In order to assess the side effects of the treatments, the patients were ass ssed at the first and the fourth weeks with Hamilton Depression Scale (HAM-D), the Suicide Probability Scale (SPS), the UPSS Impulsive Behaviour Scale, the Epworth Sleepiness Scale (ESS), the UKU Side Effect Rating Scale, and the Stroop Test and the Trail Making Test for cognitive functions.
Results: Patients on SSRIs showed better treatment response and remission rates at the end of the first month. Improvement in cognitive functions correlated with the decrease in depressive symptoms, but no difference was observed between the groups with respect to the improvement of the cognitive functions. SSRIs caused more autonomic and sexual side effects compared to agomelatine. Differences were not observed between the effects of the two medications on impulsivity, sleep pattern and suicidal tendency.
Conclusion: In conclusion, treatment with SSRIs was significantly more associated with improvement in the clinical symptoms. Sexual side effects were more prevalent with SSRIs, but the effect on cognitive functions did not differ from agomelatine Despite the distinct, promising mechanism of action, agomelatine was not as effective as the SSRIs for the treatment of depression.</description><identifier>ISSN: 1300-2163</identifier><identifier>EISSN: 2651-3463</identifier><identifier>DOI: 10.5080/u23704</identifier><identifier>PMID: 32594496</identifier><language>eng</language><publisher>YENISEHIR: Turkiye Sinir Ve Ruh Sagligi Dernegi</publisher><subject>Acetamides - adverse effects ; Acetamides - pharmacology ; Acetamides - therapeutic use ; Adult ; Antidepressants ; Antidepressive Agents - adverse effects ; Antidepressive Agents - pharmacology ; Antidepressive Agents - therapeutic use ; Cognition - drug effects ; Depressive Disorder, Major - drug therapy ; Female ; Humans ; Life Sciences & Biomedicine ; Male ; Mental depression ; Middle Aged ; Psychiatric Status Rating Scales ; Psychiatry ; Science & Technology ; Serotonin Uptake Inhibitors - adverse effects ; Serotonin Uptake Inhibitors - pharmacology ; Serotonin Uptake Inhibitors - therapeutic use ; Sleep - drug effects ; Surveys and Questionnaires ; Young Adult</subject><ispartof>Türk psikiyatri dergisi, 2020, Vol.31 (2), p.90-98</ispartof><rights>Copyright Turkiye Sinir ve Ruh Sagligi Dernegi (Turkish Association of Nervous and Mental Health) Summer 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000547323700003</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c339t-1db15d635309620c82a13778a29fff9c0fd1af1d904d03cc40d73b98db879a0c3</citedby><cites>FETCH-LOGICAL-c339t-1db15d635309620c82a13778a29fff9c0fd1af1d904d03cc40d73b98db879a0c3</cites><orcidid>0000-0003-4101-6378</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32594496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erdogan, Cigdem</creatorcontrib><creatorcontrib>Ozdemir Rezaki, Hatice</creatorcontrib><creatorcontrib>Kocak, Orhan Murat</creatorcontrib><creatorcontrib>Buturak, Sadiye Visal</creatorcontrib><title>Comparison of the Effects of Antidepressants with Different Mechanisms of Action on Efficacy, Cognitive Functions and Side Effects</title><title>Türk psikiyatri dergisi</title><addtitle>TURK PSIKIYATR DERG</addtitle><addtitle>Turk Psikiyatri Derg</addtitle><description>Objective: The aim of this study was to compare the effects of the agomelatine and selective serotonin reuptake inhibitors (SSRIs) on symptoms of depression, cognitive functions, impulsiveness, suicidal tendency, sleep pattern and side effects.
Method: This study enrolled patients with depression started on SSRIs (n=30) or agomelatine (n=30) on an outpatient basis. All patients were evaluated with SCID-I and the Sociodemographic Questionnaire on the first day of the treatment. In order to assess the side effects of the treatments, the patients were ass ssed at the first and the fourth weeks with Hamilton Depression Scale (HAM-D), the Suicide Probability Scale (SPS), the UPSS Impulsive Behaviour Scale, the Epworth Sleepiness Scale (ESS), the UKU Side Effect Rating Scale, and the Stroop Test and the Trail Making Test for cognitive functions.
Results: Patients on SSRIs showed better treatment response and remission rates at the end of the first month. Improvement in cognitive functions correlated with the decrease in depressive symptoms, but no difference was observed between the groups with respect to the improvement of the cognitive functions. SSRIs caused more autonomic and sexual side effects compared to agomelatine. Differences were not observed between the effects of the two medications on impulsivity, sleep pattern and suicidal tendency.
Conclusion: In conclusion, treatment with SSRIs was significantly more associated with improvement in the clinical symptoms. Sexual side effects were more prevalent with SSRIs, but the effect on cognitive functions did not differ from agomelatine Despite the distinct, promising mechanism of action, agomelatine was not as effective as the SSRIs for the treatment of depression.</description><subject>Acetamides - adverse effects</subject><subject>Acetamides - pharmacology</subject><subject>Acetamides - therapeutic use</subject><subject>Adult</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - adverse effects</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Cognition - drug effects</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Science & Technology</subject><subject>Serotonin Uptake Inhibitors - adverse effects</subject><subject>Serotonin Uptake Inhibitors - pharmacology</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>Sleep - drug effects</subject><subject>Surveys and Questionnaires</subject><subject>Young Adult</subject><issn>1300-2163</issn><issn>2651-3463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ARHDP</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkF1PFTEQhhsjkSPqTzBNTLyRlWlnv3pJVkASjBfI9abbD0-Jpz22XQm3_nK7LHBtbyadeeaZ5CXkHYPPDfRwMnPsoH5BNrxtWIV1iy_JhiFAxVmLh-R1SrcA2PbIX5FD5I2oa9FuyN8h7PYyuhQ8DZbmraFn1hqV0_I99dlps48mJelL687lLf3iChCNz_SbUVvpXdqtsMpusfjF4JRU98d0CD-9y-6Poeezf5gnKr2m10X7dOgNObDyVzJvH-sRuTk_-zF8ra6-X1wOp1eVQhS5YnpijW6xQRAtB9VzybDresmFtVYosJpJy7SAWgMqVYPucBK9nvpOSFB4RD6s3n0Mv2eT8ngb5ujLyZHXCKxpoGsL9XGlVAwpRWPHfXQ7Ge9HBuMS9bhGXcD3j7p52hn9jD1lW4B-Be7MFGxSznhlnjEAaOoOF1d5OLgsl3iGMPtcVj_9_yr-A5qUmao</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Erdogan, Cigdem</creator><creator>Ozdemir Rezaki, Hatice</creator><creator>Kocak, Orhan Murat</creator><creator>Buturak, Sadiye Visal</creator><general>Turkiye Sinir Ve Ruh Sagligi Dernegi</general><general>Turkiye Sinir ve Ruh Sagligi Dernegi (Turkish Association of Nervous and Mental Health)</general><scope>17B</scope><scope>ARHDP</scope><scope>BLEPL</scope><scope>DVR</scope><scope>EGQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><orcidid>https://orcid.org/0000-0003-4101-6378</orcidid></search><sort><creationdate>2020</creationdate><title>Comparison of the Effects of Antidepressants with Different Mechanisms of Action on Efficacy, Cognitive Functions and Side Effects</title><author>Erdogan, Cigdem ; Ozdemir Rezaki, Hatice ; Kocak, Orhan Murat ; Buturak, Sadiye Visal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-1db15d635309620c82a13778a29fff9c0fd1af1d904d03cc40d73b98db879a0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetamides - adverse effects</topic><topic>Acetamides - pharmacology</topic><topic>Acetamides - therapeutic use</topic><topic>Adult</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - adverse effects</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Cognition - drug effects</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Science & Technology</topic><topic>Serotonin Uptake Inhibitors - adverse effects</topic><topic>Serotonin Uptake Inhibitors - pharmacology</topic><topic>Serotonin Uptake Inhibitors - therapeutic use</topic><topic>Sleep - drug effects</topic><topic>Surveys and Questionnaires</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Erdogan, Cigdem</creatorcontrib><creatorcontrib>Ozdemir Rezaki, Hatice</creatorcontrib><creatorcontrib>Kocak, Orhan Murat</creatorcontrib><creatorcontrib>Buturak, Sadiye Visal</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science - Social Sciences Citation Index – 2020</collection><collection>Web of Science Core Collection</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><jtitle>Türk psikiyatri dergisi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erdogan, Cigdem</au><au>Ozdemir Rezaki, Hatice</au><au>Kocak, Orhan Murat</au><au>Buturak, Sadiye Visal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the Effects of Antidepressants with Different Mechanisms of Action on Efficacy, Cognitive Functions and Side Effects</atitle><jtitle>Türk psikiyatri dergisi</jtitle><stitle>TURK PSIKIYATR DERG</stitle><addtitle>Turk Psikiyatri Derg</addtitle><date>2020</date><risdate>2020</risdate><volume>31</volume><issue>2</issue><spage>90</spage><epage>98</epage><pages>90-98</pages><issn>1300-2163</issn><eissn>2651-3463</eissn><abstract>Objective: The aim of this study was to compare the effects of the agomelatine and selective serotonin reuptake inhibitors (SSRIs) on symptoms of depression, cognitive functions, impulsiveness, suicidal tendency, sleep pattern and side effects.
Method: This study enrolled patients with depression started on SSRIs (n=30) or agomelatine (n=30) on an outpatient basis. All patients were evaluated with SCID-I and the Sociodemographic Questionnaire on the first day of the treatment. In order to assess the side effects of the treatments, the patients were ass ssed at the first and the fourth weeks with Hamilton Depression Scale (HAM-D), the Suicide Probability Scale (SPS), the UPSS Impulsive Behaviour Scale, the Epworth Sleepiness Scale (ESS), the UKU Side Effect Rating Scale, and the Stroop Test and the Trail Making Test for cognitive functions.
Results: Patients on SSRIs showed better treatment response and remission rates at the end of the first month. Improvement in cognitive functions correlated with the decrease in depressive symptoms, but no difference was observed between the groups with respect to the improvement of the cognitive functions. SSRIs caused more autonomic and sexual side effects compared to agomelatine. Differences were not observed between the effects of the two medications on impulsivity, sleep pattern and suicidal tendency.
Conclusion: In conclusion, treatment with SSRIs was significantly more associated with improvement in the clinical symptoms. Sexual side effects were more prevalent with SSRIs, but the effect on cognitive functions did not differ from agomelatine Despite the distinct, promising mechanism of action, agomelatine was not as effective as the SSRIs for the treatment of depression.</abstract><cop>YENISEHIR</cop><pub>Turkiye Sinir Ve Ruh Sagligi Dernegi</pub><pmid>32594496</pmid><doi>10.5080/u23704</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4101-6378</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acetamides - adverse effects Acetamides - pharmacology Acetamides - therapeutic use Adult Antidepressants Antidepressive Agents - adverse effects Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Cognition - drug effects Depressive Disorder, Major - drug therapy Female Humans Life Sciences & Biomedicine Male Mental depression Middle Aged Psychiatric Status Rating Scales Psychiatry Science & Technology Serotonin Uptake Inhibitors - adverse effects Serotonin Uptake Inhibitors - pharmacology Serotonin Uptake Inhibitors - therapeutic use Sleep - drug effects Surveys and Questionnaires Young Adult |
| title | Comparison of the Effects of Antidepressants with Different Mechanisms of Action on Efficacy, Cognitive Functions and Side Effects |
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