MMAE delivery using the Bicycle toxin conjugate BT5528

The EphA2 receptor is found at high levels in tumors and low levels in normal tissue and high EphA2 expression in biopsies is a predictor of poor outcome in patients. Drug discovery groups have therefore sought to develop EphA2 based therapies using small molecule, peptide and nanoparticle-based app...

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Veröffentlicht in:	Molecular cancer therapeutics 2020-07, Vol.19 (7), p.1385-1394
Hauptverfasser:	Bennett, Gavin, Brown, Amy, Mudd, Gemma, Huxley, Philip, Rietschoten, Katerine Van, Pavan, Silvia, Chen, Liuhong, Watcham, Sophie, Lahdenranta, Johanna, Keen, Nicholas
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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