Insights into the Mechanism of Ethionamide Resistance in Mycobacterium tuberculosis through an in silico Structural Evaluation of EthA and Mutants Identified in Clinical Isolates

Mutation in the ethionamide (ETH) activating enzyme, EthA, is the main factor determining resistance to this drug, used to treat TB patients infected with MDR and XDRMycobacterium tuberculosisisolates. Many mutations in EthA of ETH resistant (ETH-R) isolates have been described but their roles in re...

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