Vitamin D and stress urinary incontinence in pregnancy: a cross‐sectional study
Objective To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy. Design A cross‐sectional study. Secondary analysis of a randomised controlled trial. Setting Two university hospitals in Norway. Population A total of 851 healthy, pregnant women >18 years...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2020-12, Vol.127 (13), p.1704-1711 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Stafne, SN Mørkved, S Gustafsson, MK Syversen, U Stunes, AK Salvesen, KÅ Johannessen, HH |
| description | Objective
To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy.
Design
A cross‐sectional study. Secondary analysis of a randomised controlled trial.
Setting
Two university hospitals in Norway.
Population
A total of 851 healthy, pregnant women >18 years in gestational weeks 18–22 with a singleton live fetus.
Methods
Data on UI were collected from a questionnaire at inclusion and serum analysis of 25‐hydroxy vitamin D (25(OH)D) was performed. Univariable and multivariable logistic regression analyses were applied to study associations between exposure and outcomes.
Main outcome measures
Prevalence of self‐reported UI, stress (SUI) and urge (UUI) or mixed UI.
Results
In total, 230/851 (27%) of the participants were vitamin D insufficient (25(OH)D |
| doi_str_mv | 10.1111/1471-0528.16340 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000545326000001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2408823430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4120-a9c96cf269353bd09d357209502f10ef3e895dd7f43caca16c05d3522e4990e93</originalsourceid><addsrcrecordid>eNqNkctO3DAUhi1ExWXKmh2KxKYSChzfkpgdnUKhQkKV2m4tj3OCjDLO1E5UzY5H6DPyJHVmhll0A974ou8_OuczIccUzmlaF1SUNAfJqnNacAE75GD7srs6Qw6cVfvkMMYnAFow4HtknzNRqhLoAfn-y_Vm7nz2JTO-zmIfMMZsCM6bsMyct53vnUdvMV2yRcBHb7xdXmYms6GL8eX5b0Tbu86bNqWHevmRfGhMG_Fos0_Iz5vrH9Pb_P7h69306j63gjLIjbKqsA0rFJd8VoOquSwZKAmsoYANx0rJui4bwa2xhhYWZEIYQ6EUoOIT8mlddxG63wPGXs9dtNi2xmM3RM0EVBXjgkNCT_9Dn7ohpI5HSlZCFZLSRF2sqdVgARu9CG6eNGgKerStR7d6dKtXtlPiZFN3mM2x3vKvehNQrYE_OOuaaN0ocosBgBSSswLGRafpJ0aR027wfYqevT-aaLmhXYvLtxrXn789rCf4B9b6qSo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2458496511</pqid></control><display><type>article</type><title>Vitamin D and stress urinary incontinence in pregnancy: a cross‐sectional study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Stafne, SN ; Mørkved, S ; Gustafsson, MK ; Syversen, U ; Stunes, AK ; Salvesen, KÅ ; Johannessen, HH</creator><creatorcontrib>Stafne, SN ; Mørkved, S ; Gustafsson, MK ; Syversen, U ; Stunes, AK ; Salvesen, KÅ ; Johannessen, HH</creatorcontrib><description><![CDATA[Objective
To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy.
Design
A cross‐sectional study. Secondary analysis of a randomised controlled trial.
Setting
Two university hospitals in Norway.
Population
A total of 851 healthy, pregnant women >18 years in gestational weeks 18–22 with a singleton live fetus.
Methods
Data on UI were collected from a questionnaire at inclusion and serum analysis of 25‐hydroxy vitamin D (25(OH)D) was performed. Univariable and multivariable logistic regression analyses were applied to study associations between exposure and outcomes.
Main outcome measures
Prevalence of self‐reported UI, stress (SUI) and urge (UUI) or mixed UI.
Results
In total, 230/851 (27%) of the participants were vitamin D insufficient (25(OH)D <50 nmol/l) and 42% reported to have any UI. Women with 25(OH)D <50 nmol/l were more likely to report any UI (P = 0.03) and SUI (P < 0.01) compared with women with 25(OH)D ≥50 nmol/l. In a univariable logistic regression analysis, serum levels of 25(OH)D <50 nmol/l was associated with increased risk of any UI (odds ratio [OR] 1.5 with 95% CI 1.0–2.1), SUI only (OR 1.7, 95% CI 1.2–2.4), but not mixed UI or UUI only (OR 0.8, 95% CI 0.5–1.5). In a multivariable logistic regression model, serum levels of 25(OH)D <50 nmol/l were associated with a higher risk of experiencing SUI only (OR 1.5, 95% CI 1.1–2.2).
Conclusions
Serum 25(OH)D <50 nmol/l was associated with increased risk of any UI, and SUI in particular.
Tweetable
Low levels of vitamin D are associated with increased risk of urinary incontinence in pregnancy.
Tweetable
Low levels of vitamin D are associated with increased risk of urinary incontinence in pregnancy.]]></description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/1471-0528.16340</identifier><identifier>PMID: 32479701</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>25‐hydroxy vitamin D ; Adult ; Cross-Sectional Studies ; Female ; Fetuses ; Humans ; Life Sciences & Biomedicine ; Obstetrics & Gynecology ; Pregnancy ; Pregnancy Complications - blood ; Pregnancy Complications - epidemiology ; Risk Assessment ; Science & Technology ; Serum levels ; stress urinary incontinence ; Urinary incontinence ; Urinary Incontinence, Stress - blood ; Urinary Incontinence, Stress - epidemiology ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; vitamin D insufficiency</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2020-12, Vol.127 (13), p.1704-1711</ispartof><rights>2020 The Authors. published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists</rights><rights>2020 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>14</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000545326000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4120-a9c96cf269353bd09d357209502f10ef3e895dd7f43caca16c05d3522e4990e93</citedby><cites>FETCH-LOGICAL-c4120-a9c96cf269353bd09d357209502f10ef3e895dd7f43caca16c05d3522e4990e93</cites><orcidid>0000-0003-4151-393X ; 0000-0003-4922-477X ; 0000-0003-1074-5199 ; 0000-0002-6570-3466</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1471-0528.16340$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1471-0528.16340$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,28253,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32479701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stafne, SN</creatorcontrib><creatorcontrib>Mørkved, S</creatorcontrib><creatorcontrib>Gustafsson, MK</creatorcontrib><creatorcontrib>Syversen, U</creatorcontrib><creatorcontrib>Stunes, AK</creatorcontrib><creatorcontrib>Salvesen, KÅ</creatorcontrib><creatorcontrib>Johannessen, HH</creatorcontrib><title>Vitamin D and stress urinary incontinence in pregnancy: a cross‐sectional study</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG-INT J OBSTET GY</addtitle><addtitle>BJOG</addtitle><description><![CDATA[Objective
To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy.
Design
A cross‐sectional study. Secondary analysis of a randomised controlled trial.
Setting
Two university hospitals in Norway.
Population
A total of 851 healthy, pregnant women >18 years in gestational weeks 18–22 with a singleton live fetus.
Methods
Data on UI were collected from a questionnaire at inclusion and serum analysis of 25‐hydroxy vitamin D (25(OH)D) was performed. Univariable and multivariable logistic regression analyses were applied to study associations between exposure and outcomes.
Main outcome measures
Prevalence of self‐reported UI, stress (SUI) and urge (UUI) or mixed UI.
Results
In total, 230/851 (27%) of the participants were vitamin D insufficient (25(OH)D <50 nmol/l) and 42% reported to have any UI. Women with 25(OH)D <50 nmol/l were more likely to report any UI (P = 0.03) and SUI (P < 0.01) compared with women with 25(OH)D ≥50 nmol/l. In a univariable logistic regression analysis, serum levels of 25(OH)D <50 nmol/l was associated with increased risk of any UI (odds ratio [OR] 1.5 with 95% CI 1.0–2.1), SUI only (OR 1.7, 95% CI 1.2–2.4), but not mixed UI or UUI only (OR 0.8, 95% CI 0.5–1.5). In a multivariable logistic regression model, serum levels of 25(OH)D <50 nmol/l were associated with a higher risk of experiencing SUI only (OR 1.5, 95% CI 1.1–2.2).
Conclusions
Serum 25(OH)D <50 nmol/l was associated with increased risk of any UI, and SUI in particular.
Tweetable
Low levels of vitamin D are associated with increased risk of urinary incontinence in pregnancy.
Tweetable
Low levels of vitamin D are associated with increased risk of urinary incontinence in pregnancy.]]></description><subject>25‐hydroxy vitamin D</subject><subject>Adult</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Fetuses</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Obstetrics & Gynecology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - blood</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Risk Assessment</subject><subject>Science & Technology</subject><subject>Serum levels</subject><subject>stress urinary incontinence</subject><subject>Urinary incontinence</subject><subject>Urinary Incontinence, Stress - blood</subject><subject>Urinary Incontinence, Stress - epidemiology</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>vitamin D insufficiency</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkctO3DAUhi1ExWXKmh2KxKYSChzfkpgdnUKhQkKV2m4tj3OCjDLO1E5UzY5H6DPyJHVmhll0A974ou8_OuczIccUzmlaF1SUNAfJqnNacAE75GD7srs6Qw6cVfvkMMYnAFow4HtknzNRqhLoAfn-y_Vm7nz2JTO-zmIfMMZsCM6bsMyct53vnUdvMV2yRcBHb7xdXmYms6GL8eX5b0Tbu86bNqWHevmRfGhMG_Fos0_Iz5vrH9Pb_P7h69306j63gjLIjbKqsA0rFJd8VoOquSwZKAmsoYANx0rJui4bwa2xhhYWZEIYQ6EUoOIT8mlddxG63wPGXs9dtNi2xmM3RM0EVBXjgkNCT_9Dn7ohpI5HSlZCFZLSRF2sqdVgARu9CG6eNGgKerStR7d6dKtXtlPiZFN3mM2x3vKvehNQrYE_OOuaaN0ocosBgBSSswLGRafpJ0aR027wfYqevT-aaLmhXYvLtxrXn789rCf4B9b6qSo</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Stafne, SN</creator><creator>Mørkved, S</creator><creator>Gustafsson, MK</creator><creator>Syversen, U</creator><creator>Stunes, AK</creator><creator>Salvesen, KÅ</creator><creator>Johannessen, HH</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4151-393X</orcidid><orcidid>https://orcid.org/0000-0003-4922-477X</orcidid><orcidid>https://orcid.org/0000-0003-1074-5199</orcidid><orcidid>https://orcid.org/0000-0002-6570-3466</orcidid></search><sort><creationdate>202012</creationdate><title>Vitamin D and stress urinary incontinence in pregnancy: a cross‐sectional study</title><author>Stafne, SN ; Mørkved, S ; Gustafsson, MK ; Syversen, U ; Stunes, AK ; Salvesen, KÅ ; Johannessen, HH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4120-a9c96cf269353bd09d357209502f10ef3e895dd7f43caca16c05d3522e4990e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>25‐hydroxy vitamin D</topic><topic>Adult</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Fetuses</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Obstetrics & Gynecology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - blood</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Risk Assessment</topic><topic>Science & Technology</topic><topic>Serum levels</topic><topic>stress urinary incontinence</topic><topic>Urinary incontinence</topic><topic>Urinary Incontinence, Stress - blood</topic><topic>Urinary Incontinence, Stress - epidemiology</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>vitamin D insufficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stafne, SN</creatorcontrib><creatorcontrib>Mørkved, S</creatorcontrib><creatorcontrib>Gustafsson, MK</creatorcontrib><creatorcontrib>Syversen, U</creatorcontrib><creatorcontrib>Stunes, AK</creatorcontrib><creatorcontrib>Salvesen, KÅ</creatorcontrib><creatorcontrib>Johannessen, HH</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stafne, SN</au><au>Mørkved, S</au><au>Gustafsson, MK</au><au>Syversen, U</au><au>Stunes, AK</au><au>Salvesen, KÅ</au><au>Johannessen, HH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D and stress urinary incontinence in pregnancy: a cross‐sectional study</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><stitle>BJOG-INT J OBSTET GY</stitle><addtitle>BJOG</addtitle><date>2020-12</date><risdate>2020</risdate><volume>127</volume><issue>13</issue><spage>1704</spage><epage>1711</epage><pages>1704-1711</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><abstract><![CDATA[Objective
To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy.
Design
A cross‐sectional study. Secondary analysis of a randomised controlled trial.
Setting
Two university hospitals in Norway.
Population
A total of 851 healthy, pregnant women >18 years in gestational weeks 18–22 with a singleton live fetus.
Methods
Data on UI were collected from a questionnaire at inclusion and serum analysis of 25‐hydroxy vitamin D (25(OH)D) was performed. Univariable and multivariable logistic regression analyses were applied to study associations between exposure and outcomes.
Main outcome measures
Prevalence of self‐reported UI, stress (SUI) and urge (UUI) or mixed UI.
Results
In total, 230/851 (27%) of the participants were vitamin D insufficient (25(OH)D <50 nmol/l) and 42% reported to have any UI. Women with 25(OH)D <50 nmol/l were more likely to report any UI (P = 0.03) and SUI (P < 0.01) compared with women with 25(OH)D ≥50 nmol/l. In a univariable logistic regression analysis, serum levels of 25(OH)D <50 nmol/l was associated with increased risk of any UI (odds ratio [OR] 1.5 with 95% CI 1.0–2.1), SUI only (OR 1.7, 95% CI 1.2–2.4), but not mixed UI or UUI only (OR 0.8, 95% CI 0.5–1.5). In a multivariable logistic regression model, serum levels of 25(OH)D <50 nmol/l were associated with a higher risk of experiencing SUI only (OR 1.5, 95% CI 1.1–2.2).
Conclusions
Serum 25(OH)D <50 nmol/l was associated with increased risk of any UI, and SUI in particular.
Tweetable
Low levels of vitamin D are associated with increased risk of urinary incontinence in pregnancy.
Tweetable
Low levels of vitamin D are associated with increased risk of urinary incontinence in pregnancy.]]></abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>32479701</pmid><doi>10.1111/1471-0528.16340</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4151-393X</orcidid><orcidid>https://orcid.org/0000-0003-4922-477X</orcidid><orcidid>https://orcid.org/0000-0003-1074-5199</orcidid><orcidid>https://orcid.org/0000-0002-6570-3466</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2020-12, Vol.127 (13), p.1704-1711 |
| issn | 1470-0328 1471-0528 |
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| subjects | 25‐hydroxy vitamin D Adult Cross-Sectional Studies Female Fetuses Humans Life Sciences & Biomedicine Obstetrics & Gynecology Pregnancy Pregnancy Complications - blood Pregnancy Complications - epidemiology Risk Assessment Science & Technology Serum levels stress urinary incontinence Urinary incontinence Urinary Incontinence, Stress - blood Urinary Incontinence, Stress - epidemiology Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood vitamin D insufficiency |
| title | Vitamin D and stress urinary incontinence in pregnancy: a cross‐sectional study |
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