circRNA_001275 upregulates Wnt7a expression by competitively sponging miR-370-3p to promote cisplatin resistance in esophageal cancer
Circular RNAs (circRNAs) are aberrantly expressed in various tumors and are associated with tumorigenesis. The present study aimed to determine the role of circRNA_001275 in cisplatin-resistant esophageal cancer. Three pairs of cisplatin-resistant tissues and corresponding adjacent tissues were coll...
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| Veröffentlicht in: | International journal of oncology 2020-07, Vol.57 (1), p.151-160 |
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| container_title | International journal of oncology |
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| creator | Zou, Fang-Wen Yang, Shi-Ze Li, Wen-Ya Liu, Chao-Yuan Liu, Xu-Hong Hu, Chun-Hong Liu, Zheng-Hua Xu, Shun |
| description | Circular RNAs (circRNAs) are aberrantly expressed in various tumors and are associated with tumorigenesis. The present study aimed to determine the role of circRNA_001275 in cisplatin-resistant esophageal cancer. Three pairs of cisplatin-resistant tissues and corresponding adjacent tissues were collected and subjected to circRNA chip analysis. Additionally, the effect of circRNA_001275 on cisplatin-resistant cells was investigated. The relationship between circRNA_001275, microRNAs (miRs) and target genes were analyzed using luciferase assays, and validated via reverse transcription-quantitative PCR (RT-qPCR) and western blotting. The results showed that circRNA_001275 was significantly upregulated in cisplatin-resistant esophageal cancer tissues and cells (P |
| doi_str_mv | 10.3892/ijo.2020.5050 |
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| fullrecord | <record><control><sourceid>gale_webof</sourceid><recordid>TN_cdi_webofscience_primary_000544982500012CitationCount</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A628079226</galeid><sourcerecordid>A628079226</sourcerecordid><originalsourceid>FETCH-LOGICAL-c513t-3eead356c630c9b162fc3c0e6146437e08a1f7d88ae8cf03ac69aba625c2f31d3</originalsourceid><addsrcrecordid>eNqNkt-L1DAQx4so3nn66KsEhHuRrpOkTdsXYVnOH3AoHIqPIZuddrO0SU3S0_0D7v82Zc_1FnyQPCSZfObLzOSbZS8pLHjdsLdm5xYMGCxKKOFRdk6rhuasYPxxOgNtclHw5ix7FsIOgJUl0KfZGWecNoLy8-xOG69vPi8lAGVVSabRYzf1KmIg322sFMFfKRSCcZas90S7YcRoornFfk_C6GxnbEcGc5PzCnI-kujI6N3gIhJtwpikjCVJwYSorEaSbhjcuFUdqp7oOeafZ09a1Qd8cb9fZN_eX31dfcyvv3z4tFpe57qkPOYcUW14KbTgoJs1FazVXAMKWqQuK4Ra0bba1LXCWrfAlRaNWivBSs1aTjf8Int30B2n9YAbjTZ61cvRm0H5vXTKyNMXa7ayc7eyYiUrBEsCr-8FvPsxYYhy5yZvU82SFZRzRrlo_lKd6lEa27okpgcTtFwKVkPVMCYStfgHldYGB6Odxdak-EnC5YOEbRpf3AbXTzH9TTgF8wOovQvBY3vskIKcXSOTa-TsGjm7JvGvHo7lSP-xSQLqA_AT164N2mD6tSMGAGVRNDUrYXbRykQ1l7Ryk40p9c3_p_LfU8rePQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2413321369</pqid></control><display><type>article</type><title>circRNA_001275 upregulates Wnt7a expression by competitively sponging miR-370-3p to promote cisplatin resistance in esophageal cancer</title><source>Spandidos Publications Journals</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Alma/SFX Local Collection</source><creator>Zou, Fang-Wen ; Yang, Shi-Ze ; Li, Wen-Ya ; Liu, Chao-Yuan ; Liu, Xu-Hong ; Hu, Chun-Hong ; Liu, Zheng-Hua ; Xu, Shun</creator><creatorcontrib>Zou, Fang-Wen ; Yang, Shi-Ze ; Li, Wen-Ya ; Liu, Chao-Yuan ; Liu, Xu-Hong ; Hu, Chun-Hong ; Liu, Zheng-Hua ; Xu, Shun</creatorcontrib><description>Circular RNAs (circRNAs) are aberrantly expressed in various tumors and are associated with tumorigenesis. The present study aimed to determine the role of circRNA_001275 in cisplatin-resistant esophageal cancer. Three pairs of cisplatin-resistant tissues and corresponding adjacent tissues were collected and subjected to circRNA chip analysis. Additionally, the effect of circRNA_001275 on cisplatin-resistant cells was investigated. The relationship between circRNA_001275, microRNAs (miRs) and target genes were analyzed using luciferase assays, and validated via reverse transcription-quantitative PCR (RT-qPCR) and western blotting. The results showed that circRNA_001275 was significantly upregulated in cisplatin-resistant esophageal cancer tissues and cells (P<0.05). Overexpression of circRNA_001275 promoted the proliferation and invasion, and decreased the apoptosis of cisplatin-resistant cells. On the other hand, circRNA_001275 silencing inhibited cell proliferation and invasion, and promoted cell apoptosis (P<0.05). Dual-luciferase reporter assays revealed that circRNA_001275 directly binds to miR-370-3p, and that Wnt family member 7A (Wnt7a) is targeted by miR-370-3p. RT-qPCR and western blotting further demonstrated that circRNA_001275 serves as an miR-370-3p sponge to upregulate Wnt7a expression. In conclusion, the present study revealed that circRNA_001275 was upregulated in cisplatin-resistant esophageal cancer and promoted cisplatin resistance by sponging miR-370-3p to upregulate Wnt7a expression. Therefore circRNA_001275 may serve as a potential diagnostic biomarker and therapeutic target for patients with cisplatin-resistant esophageal cancer.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2020.5050</identifier><identifier>PMID: 32319613</identifier><language>eng</language><publisher>ATHENS: Spandidos Publ Ltd</publisher><subject>Aged ; Analysis ; Apoptosis - genetics ; Biotechnology ; Cancer therapies ; Cell Line, Tumor ; Cell Movement - genetics ; Cell Proliferation - genetics ; Chemotherapy ; Cisplatin - pharmacology ; Cisplatin - therapeutic use ; Drug Resistance, Neoplasm - genetics ; Esophageal cancer ; Esophageal Neoplasms - drug therapy ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - pathology ; Gene expression ; Gene Expression Regulation, Neoplastic ; Health aspects ; Humans ; Life Sciences & Biomedicine ; Luciferase ; Male ; MicroRNAs ; MicroRNAs - metabolism ; Middle Aged ; Oncology ; Proteins ; RNA, Circular - metabolism ; Science & Technology ; Thoracic surgery ; Transcription (Genetics) ; Up-Regulation ; Wnt Proteins - genetics</subject><ispartof>International journal of oncology, 2020-07, Vol.57 (1), p.151-160</ispartof><rights>COPYRIGHT 2020 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2020</rights><rights>Copyright: © Zou et al. 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>39</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000544982500012</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c513t-3eead356c630c9b162fc3c0e6146437e08a1f7d88ae8cf03ac69aba625c2f31d3</citedby><cites>FETCH-LOGICAL-c513t-3eead356c630c9b162fc3c0e6146437e08a1f7d88ae8cf03ac69aba625c2f31d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930,28253</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32319613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zou, Fang-Wen</creatorcontrib><creatorcontrib>Yang, Shi-Ze</creatorcontrib><creatorcontrib>Li, Wen-Ya</creatorcontrib><creatorcontrib>Liu, Chao-Yuan</creatorcontrib><creatorcontrib>Liu, Xu-Hong</creatorcontrib><creatorcontrib>Hu, Chun-Hong</creatorcontrib><creatorcontrib>Liu, Zheng-Hua</creatorcontrib><creatorcontrib>Xu, Shun</creatorcontrib><title>circRNA_001275 upregulates Wnt7a expression by competitively sponging miR-370-3p to promote cisplatin resistance in esophageal cancer</title><title>International journal of oncology</title><addtitle>INT J ONCOL</addtitle><addtitle>Int J Oncol</addtitle><description>Circular RNAs (circRNAs) are aberrantly expressed in various tumors and are associated with tumorigenesis. The present study aimed to determine the role of circRNA_001275 in cisplatin-resistant esophageal cancer. Three pairs of cisplatin-resistant tissues and corresponding adjacent tissues were collected and subjected to circRNA chip analysis. Additionally, the effect of circRNA_001275 on cisplatin-resistant cells was investigated. The relationship between circRNA_001275, microRNAs (miRs) and target genes were analyzed using luciferase assays, and validated via reverse transcription-quantitative PCR (RT-qPCR) and western blotting. The results showed that circRNA_001275 was significantly upregulated in cisplatin-resistant esophageal cancer tissues and cells (P<0.05). Overexpression of circRNA_001275 promoted the proliferation and invasion, and decreased the apoptosis of cisplatin-resistant cells. On the other hand, circRNA_001275 silencing inhibited cell proliferation and invasion, and promoted cell apoptosis (P<0.05). Dual-luciferase reporter assays revealed that circRNA_001275 directly binds to miR-370-3p, and that Wnt family member 7A (Wnt7a) is targeted by miR-370-3p. RT-qPCR and western blotting further demonstrated that circRNA_001275 serves as an miR-370-3p sponge to upregulate Wnt7a expression. In conclusion, the present study revealed that circRNA_001275 was upregulated in cisplatin-resistant esophageal cancer and promoted cisplatin resistance by sponging miR-370-3p to upregulate Wnt7a expression. Therefore circRNA_001275 may serve as a potential diagnostic biomarker and therapeutic target for patients with cisplatin-resistant esophageal cancer.</description><subject>Aged</subject><subject>Analysis</subject><subject>Apoptosis - genetics</subject><subject>Biotechnology</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation - genetics</subject><subject>Chemotherapy</subject><subject>Cisplatin - pharmacology</subject><subject>Cisplatin - therapeutic use</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - drug therapy</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Luciferase</subject><subject>Male</subject><subject>MicroRNAs</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Proteins</subject><subject>RNA, Circular - metabolism</subject><subject>Science & Technology</subject><subject>Thoracic surgery</subject><subject>Transcription (Genetics)</subject><subject>Up-Regulation</subject><subject>Wnt Proteins - genetics</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkt-L1DAQx4so3nn66KsEhHuRrpOkTdsXYVnOH3AoHIqPIZuddrO0SU3S0_0D7v82Zc_1FnyQPCSZfObLzOSbZS8pLHjdsLdm5xYMGCxKKOFRdk6rhuasYPxxOgNtclHw5ix7FsIOgJUl0KfZGWecNoLy8-xOG69vPi8lAGVVSabRYzf1KmIg322sFMFfKRSCcZas90S7YcRoornFfk_C6GxnbEcGc5PzCnI-kujI6N3gIhJtwpikjCVJwYSorEaSbhjcuFUdqp7oOeafZ09a1Qd8cb9fZN_eX31dfcyvv3z4tFpe57qkPOYcUW14KbTgoJs1FazVXAMKWqQuK4Ra0bba1LXCWrfAlRaNWivBSs1aTjf8Int30B2n9YAbjTZ61cvRm0H5vXTKyNMXa7ayc7eyYiUrBEsCr-8FvPsxYYhy5yZvU82SFZRzRrlo_lKd6lEa27okpgcTtFwKVkPVMCYStfgHldYGB6Odxdak-EnC5YOEbRpf3AbXTzH9TTgF8wOovQvBY3vskIKcXSOTa-TsGjm7JvGvHo7lSP-xSQLqA_AT164N2mD6tSMGAGVRNDUrYXbRykQ1l7Ryk40p9c3_p_LfU8rePQ</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Zou, Fang-Wen</creator><creator>Yang, Shi-Ze</creator><creator>Li, Wen-Ya</creator><creator>Liu, Chao-Yuan</creator><creator>Liu, Xu-Hong</creator><creator>Hu, Chun-Hong</creator><creator>Liu, Zheng-Hua</creator><creator>Xu, Shun</creator><general>Spandidos Publ Ltd</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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The present study aimed to determine the role of circRNA_001275 in cisplatin-resistant esophageal cancer. Three pairs of cisplatin-resistant tissues and corresponding adjacent tissues were collected and subjected to circRNA chip analysis. Additionally, the effect of circRNA_001275 on cisplatin-resistant cells was investigated. The relationship between circRNA_001275, microRNAs (miRs) and target genes were analyzed using luciferase assays, and validated via reverse transcription-quantitative PCR (RT-qPCR) and western blotting. The results showed that circRNA_001275 was significantly upregulated in cisplatin-resistant esophageal cancer tissues and cells (P<0.05). Overexpression of circRNA_001275 promoted the proliferation and invasion, and decreased the apoptosis of cisplatin-resistant cells. On the other hand, circRNA_001275 silencing inhibited cell proliferation and invasion, and promoted cell apoptosis (P<0.05). Dual-luciferase reporter assays revealed that circRNA_001275 directly binds to miR-370-3p, and that Wnt family member 7A (Wnt7a) is targeted by miR-370-3p. RT-qPCR and western blotting further demonstrated that circRNA_001275 serves as an miR-370-3p sponge to upregulate Wnt7a expression. In conclusion, the present study revealed that circRNA_001275 was upregulated in cisplatin-resistant esophageal cancer and promoted cisplatin resistance by sponging miR-370-3p to upregulate Wnt7a expression. Therefore circRNA_001275 may serve as a potential diagnostic biomarker and therapeutic target for patients with cisplatin-resistant esophageal cancer.</abstract><cop>ATHENS</cop><pub>Spandidos Publ Ltd</pub><pmid>32319613</pmid><doi>10.3892/ijo.2020.5050</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Analysis Apoptosis - genetics Biotechnology Cancer therapies Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Chemotherapy Cisplatin - pharmacology Cisplatin - therapeutic use Drug Resistance, Neoplasm - genetics Esophageal cancer Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Gene expression Gene Expression Regulation, Neoplastic Health aspects Humans Life Sciences & Biomedicine Luciferase Male MicroRNAs MicroRNAs - metabolism Middle Aged Oncology Proteins RNA, Circular - metabolism Science & Technology Thoracic surgery Transcription (Genetics) Up-Regulation Wnt Proteins - genetics |
| title | circRNA_001275 upregulates Wnt7a expression by competitively sponging miR-370-3p to promote cisplatin resistance in esophageal cancer |
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