Recent advances in N-heterocyclic carbene-based radical catalysis
In nature, a number of enzymes use thiamine diphosphate as a coenzyme to catalyze the pyruvate decarboxylation. The resultant enamine, a so-called "Breslow intermediate," is known to perform single electron transfer to various electron acceptors. Inspired by this enzymatic catalysis, N-het...
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Veröffentlicht in: | Chemical science (Cambridge) 2020-05, Vol.11 (22), p.563-5636 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | In nature, a number of enzymes use thiamine diphosphate as a coenzyme to catalyze the pyruvate decarboxylation. The resultant enamine, a so-called "Breslow intermediate," is known to perform single electron transfer to various electron acceptors. Inspired by this enzymatic catalysis, N-heterocyclic carbene (NHC)-catalyzed radical reactions have been developed. This minireview highlights the recent progress and developments in NHC-based radical catalysis. This minireview is categorized according to the reaction types; oxidation type reaction and carbon-carbon bond formation through single electron transfer/radical-radical coupling.
This minireview examines the history and state-of-the-art of the N-heterocyclic carbene-based radical catalysis. |
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ISSN: | 2041-6520 2041-6539 |
DOI: | 10.1039/d0sc01538e |