The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology

Quantitative systems pharmacology (QSP) has emerged as a transformative science in drug discovery and development. It is now time to fully rethink the biological functions of drug metabolizing enzymes (DMEs) and transporters within the framework of QSP models. The large set of DME and transporter ge...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2020-07, Vol.108 (1), p.40-53
Hauptverfasser:	Nigam, Sanjay K., Bush, Kevin T., Bhatnagar, Vibha, Poloyac, Samuel M., Momper, Jeremiah D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Drug Development - methods Enzymes - metabolism Humans Life Sciences & Biomedicine Membrane Transport Proteins - metabolism Metabolomics Models, Biological Pharmaceutical Preparations - metabolism Pharmacology & Pharmacy Review Science & Technology Systems Biology - methods
Online-Zugang:	Volltext
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