Multifunctional Complexes Based on Photoluminescent Upconversion Nanoparticles for Theranostics of the HER2-Positive Tumors
Combining diagnostic and therapeutic functions in one agent is a promising strategy in the development of personalized approaches to the treatment of cancer. The opportunity to combine diagnostics and therapy appeared with the development of nanobiotechnologies and was realized in the concept of the...
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| Veröffentlicht in: | Doklady. Biochemistry and biophysics 2020-03, Vol.491 (1), p.73-76 |
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| creator | Guryev, E. L. Smyshlyaeva, A. S. Shilyagina, N. Yu Shanwar, S. Kostyuk, A. B. Shulga, A. A. Konovalova, E. V. Zvyagin, A. V. Deyev, S. M. Petrov, R. V. |
| description | Combining diagnostic and therapeutic functions in one agent is a promising strategy in the development of personalized approaches to the treatment of cancer. The opportunity to combine diagnostics and therapy appeared with the development of nanobiotechnologies and was realized in the concept of theranostics. To date, a number of promising agents based on nanomaterials capable of diagnosing, targeted therapeutic effects, and monitoring the response of tumor cells were obtained within the approach of theranostics. In this work, a new type of theranostic complexes based on upconversion nanoparticles coated with polyethylene glycol and functionalized with the DARPin–LoPE recombinant targeted toxin was developed. Selective binding of complexes to human breast adenocarcinoma cells overexpressing the HER2 receptor and specific toxicity to them were shown. |
| doi_str_mv | 10.1134/S160767292002009X |
| format | Article |
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L. ; Smyshlyaeva, A. S. ; Shilyagina, N. Yu ; Shanwar, S. ; Kostyuk, A. B. ; Shulga, A. A. ; Konovalova, E. V. ; Zvyagin, A. V. ; Deyev, S. M. ; Petrov, R. V.</creator><creatorcontrib>Guryev, E. L. ; Smyshlyaeva, A. S. ; Shilyagina, N. Yu ; Shanwar, S. ; Kostyuk, A. B. ; Shulga, A. A. ; Konovalova, E. V. ; Zvyagin, A. V. ; Deyev, S. M. ; Petrov, R. V.</creatorcontrib><description>Combining diagnostic and therapeutic functions in one agent is a promising strategy in the development of personalized approaches to the treatment of cancer. The opportunity to combine diagnostics and therapy appeared with the development of nanobiotechnologies and was realized in the concept of theranostics. To date, a number of promising agents based on nanomaterials capable of diagnosing, targeted therapeutic effects, and monitoring the response of tumor cells were obtained within the approach of theranostics. In this work, a new type of theranostic complexes based on upconversion nanoparticles coated with polyethylene glycol and functionalized with the DARPin–LoPE recombinant targeted toxin was developed. Selective binding of complexes to human breast adenocarcinoma cells overexpressing the HER2 receptor and specific toxicity to them were shown.</description><identifier>ISSN: 1607-6729</identifier><identifier>EISSN: 1608-3091</identifier><identifier>DOI: 10.1134/S160767292002009X</identifier><identifier>PMID: 32483755</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Adenocarcinoma ; Animals ; Biochemistry ; Biochemistry & Molecular Biology ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Breast ; Breast Neoplasms - metabolism ; Breast Neoplasms - therapy ; CHO Cells ; Cricetinae ; Cricetulus ; ErbB-2 protein ; Female ; Humans ; Life Sciences ; Life Sciences & Biomedicine ; Luminescence ; Molecular Biology ; Nanoparticles ; Nanoparticles - chemistry ; Nanostructures - chemistry ; Nanotechnology ; Photochemistry ; Polyethylene glycol ; Polyethylene Glycols - chemistry ; Precision medicine ; Protein Binding ; Receptor, ErbB-2 - metabolism ; Science & Technology ; Theranostic Nanomedicine ; Thulium - chemistry ; Toxicity ; Tumor cells ; Tumors ; Ytterbium - chemistry</subject><ispartof>Doklady. 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L.</creatorcontrib><creatorcontrib>Smyshlyaeva, A. S.</creatorcontrib><creatorcontrib>Shilyagina, N. Yu</creatorcontrib><creatorcontrib>Shanwar, S.</creatorcontrib><creatorcontrib>Kostyuk, A. B.</creatorcontrib><creatorcontrib>Shulga, A. A.</creatorcontrib><creatorcontrib>Konovalova, E. V.</creatorcontrib><creatorcontrib>Zvyagin, A. V.</creatorcontrib><creatorcontrib>Deyev, S. M.</creatorcontrib><creatorcontrib>Petrov, R. V.</creatorcontrib><title>Multifunctional Complexes Based on Photoluminescent Upconversion Nanoparticles for Theranostics of the HER2-Positive Tumors</title><title>Doklady. Biochemistry and biophysics</title><addtitle>Dokl Biochem Biophys</addtitle><addtitle>DOKL BIOCHEM BIOPHYS</addtitle><addtitle>Dokl Biochem Biophys</addtitle><description>Combining diagnostic and therapeutic functions in one agent is a promising strategy in the development of personalized approaches to the treatment of cancer. The opportunity to combine diagnostics and therapy appeared with the development of nanobiotechnologies and was realized in the concept of theranostics. To date, a number of promising agents based on nanomaterials capable of diagnosing, targeted therapeutic effects, and monitoring the response of tumor cells were obtained within the approach of theranostics. In this work, a new type of theranostic complexes based on upconversion nanoparticles coated with polyethylene glycol and functionalized with the DARPin–LoPE recombinant targeted toxin was developed. Selective binding of complexes to human breast adenocarcinoma cells overexpressing the HER2 receptor and specific toxicity to them were shown.</description><subject>Adenocarcinoma</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Breast</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - therapy</subject><subject>CHO Cells</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>ErbB-2 protein</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Life Sciences & Biomedicine</subject><subject>Luminescence</subject><subject>Molecular Biology</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanostructures - chemistry</subject><subject>Nanotechnology</subject><subject>Photochemistry</subject><subject>Polyethylene glycol</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Precision medicine</subject><subject>Protein Binding</subject><subject>Receptor, ErbB-2 - metabolism</subject><subject>Science & Technology</subject><subject>Theranostic Nanomedicine</subject><subject>Thulium - chemistry</subject><subject>Toxicity</subject><subject>Tumor cells</subject><subject>Tumors</subject><subject>Ytterbium - chemistry</subject><issn>1607-6729</issn><issn>1608-3091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkd1r1jAUxoM43If-Ad5IwEup5qtNe6llbsLchr4D70qanvhmtEmXpFPxnzf1nfNiCEIgh5Pf83DOE4SeU_KaUi7efKYVkZVkDSMkn-bLI3SQW3XBSUMf_65lsb7vo8MYr1eI8fIJ2udM1FyW5QH6-XEZkzWL08l6p0bc-mke4TtE_E5FGLB3-HLrkx-XyTqIGlzCV7P27hZCzBJ8rpyfVUhWj1lkfMCbLYTcjLkVsTc4bQGfHn9ixaWPNtlbwJtl8iE-RXtGjRGe3d1H6Or98aY9Lc4uTj60b88KzSVLheolg55yXbEGFKt03Q-NEaURpKS1pLWSle57QSshOBl6maOpQQHvqRGCDvwIvdz5zsHfLBBTd-2XkJeNHROkLkuSXTJFd5QOPsYAppuDnVT40VHSrXF3D-LOmhd3zks_wXCv-JNvBl7tgG_QexO1BafhHiOElHkAKRqylpmu_59ubVLrn7V-cSlL2U4aM-6-Qvi747_H_wXokKxj</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Guryev, E. 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| ispartof | Doklady. Biochemistry and biophysics, 2020-03, Vol.491 (1), p.73-76 |
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| subjects | Adenocarcinoma Animals Biochemistry Biochemistry & Molecular Biology Biological and Medical Physics Biomedical and Life Sciences Biophysics Breast Breast Neoplasms - metabolism Breast Neoplasms - therapy CHO Cells Cricetinae Cricetulus ErbB-2 protein Female Humans Life Sciences Life Sciences & Biomedicine Luminescence Molecular Biology Nanoparticles Nanoparticles - chemistry Nanostructures - chemistry Nanotechnology Photochemistry Polyethylene glycol Polyethylene Glycols - chemistry Precision medicine Protein Binding Receptor, ErbB-2 - metabolism Science & Technology Theranostic Nanomedicine Thulium - chemistry Toxicity Tumor cells Tumors Ytterbium - chemistry |
| title | Multifunctional Complexes Based on Photoluminescent Upconversion Nanoparticles for Theranostics of the HER2-Positive Tumors |
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