Biodegradable zinc oxide composite scaffolds promote osteochondral differentiation of mesenchymal stem cells
Osteoarthritis (OA) involves the degeneration of articular cartilage and subchondral bone. The capacity of articular cartilage to repair and regenerate is limited. A biodegradable, fibrous scaffold containing zinc oxide (ZnO) was fabricated and evaluated for osteochondral tissue engineering applicat...
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| Veröffentlicht in: | Biotechnology and bioengineering 2020-01, Vol.117 (1), p.194-209 |
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| description | Osteoarthritis (OA) involves the degeneration of articular cartilage and subchondral bone. The capacity of articular cartilage to repair and regenerate is limited. A biodegradable, fibrous scaffold containing zinc oxide (ZnO) was fabricated and evaluated for osteochondral tissue engineering applications. ZnO has shown promise for a variety of biomedical applications but has had limited use in tissue engineering. Composite scaffolds consisted of ZnO nanoparticles embedded in slow degrading, polycaprolactone to allow for dissolution of zinc ions over time. Zinc has well‐known insulin‐mimetic properties and can be beneficial for cartilage and bone regeneration. Fibrous ZnO composite scaffolds, having varying concentrations of 1–10 wt.% ZnO, were fabricated using the electrospinning technique and evaluated for human mesenchymal stem cell (MSC) differentiation along chondrocyte and osteoblast lineages. Slow release of the zinc was observed for all ZnO composite scaffolds. MSC chondrogenic differentiation was promoted on low percentage ZnO composite scaffolds as indicated by the highest collagen type II production and expression of cartilage‐specific genes, while osteogenic differentiation was promoted on high percentage ZnO composite scaffolds as indicated by the highest alkaline phosphatase activity, collagen production, and expression of bone‐specific genes. This study demonstrates the feasibility of ZnO‐containing composites as a potential scaffold for osteochondral tissue engineering.
Osteoarthritis involves the degeneration of articular cartilage and subchondral bone. A biodegradable, fibrous scaffold containing zinc oxide (ZnO) was fabricated and evaluated for its potential use for osteochondral tissue engineering applications. Scaffolds containing a low percentage of ZnO promotes mesenchymal stem cells (MSCs) to become cartilage cells and a high percentage of ZnO promotes MSCs to become bone cells, suggesting a biphasic scaffold design will be needed for osteochondral repair. |
| doi_str_mv | 10.1002/bit.27173 |
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Osteoarthritis involves the degeneration of articular cartilage and subchondral bone. A biodegradable, fibrous scaffold containing zinc oxide (ZnO) was fabricated and evaluated for its potential use for osteochondral tissue engineering applications. Scaffolds containing a low percentage of ZnO promotes mesenchymal stem cells (MSCs) to become cartilage cells and a high percentage of ZnO promotes MSCs to become bone cells, suggesting a biphasic scaffold design will be needed for osteochondral repair.</description><identifier>ISSN: 0006-3592</identifier><identifier>EISSN: 1097-0290</identifier><identifier>DOI: 10.1002/bit.27173</identifier><identifier>PMID: 31544962</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>Alkaline phosphatase ; Biodegradability ; Biodegradation ; Biomedical engineering ; Biomedical materials ; Biotechnology & Applied Microbiology ; Bone growth ; Cartilage ; Cartilage (articular) ; Cartilage diseases ; Cell differentiation ; Cell Differentiation - drug effects ; Cell Survival - drug effects ; Cells, Cultured ; Chondrocytes ; Chondrogenesis ; Chondrogenesis - drug effects ; Collagen ; Collagen (type II) ; Degeneration ; Differentiation (biology) ; Electrochemical Techniques ; electrospinning ; Feasibility studies ; Gene expression ; Genes ; Insulin ; Life Sciences & Biomedicine ; Mesenchymal stem cells ; Mesenchymal Stem Cells - drug effects ; Mesenchyme ; Nanocomposites - chemistry ; Nanoparticles ; Osteoarthritis ; Osteoblastogenesis ; osteochondral differentiation ; Osteogenesis - drug effects ; Polycaprolactone ; Polyesters - chemistry ; Regeneration ; Regeneration (physiology) ; Scaffolds ; Science & Technology ; Stem cells ; Subchondral bone ; Tissue Engineering ; Tissue Scaffolds - chemistry ; Zinc ; Zinc oxide ; Zinc Oxide - chemistry ; Zinc Oxide - pharmacology ; zinc oxide composite ; Zinc oxides</subject><ispartof>Biotechnology and bioengineering, 2020-01, Vol.117 (1), p.194-209</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>59</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000540525200017</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3903-b83564872410ac601772e9f69965812dc6d258a8aae79bd2aa426e0975edb34d3</citedby><cites>FETCH-LOGICAL-c3903-b83564872410ac601772e9f69965812dc6d258a8aae79bd2aa426e0975edb34d3</cites><orcidid>0000-0002-9485-2364 ; 0000-0002-8168-6109</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbit.27173$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbit.27173$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,28253,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31544962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khader, Ateka</creatorcontrib><creatorcontrib>Arinzeh, Treena Livingston</creatorcontrib><title>Biodegradable zinc oxide composite scaffolds promote osteochondral differentiation of mesenchymal stem cells</title><title>Biotechnology and bioengineering</title><addtitle>BIOTECHNOL BIOENG</addtitle><addtitle>Biotechnol Bioeng</addtitle><description>Osteoarthritis (OA) involves the degeneration of articular cartilage and subchondral bone. The capacity of articular cartilage to repair and regenerate is limited. A biodegradable, fibrous scaffold containing zinc oxide (ZnO) was fabricated and evaluated for osteochondral tissue engineering applications. ZnO has shown promise for a variety of biomedical applications but has had limited use in tissue engineering. Composite scaffolds consisted of ZnO nanoparticles embedded in slow degrading, polycaprolactone to allow for dissolution of zinc ions over time. Zinc has well‐known insulin‐mimetic properties and can be beneficial for cartilage and bone regeneration. Fibrous ZnO composite scaffolds, having varying concentrations of 1–10 wt.% ZnO, were fabricated using the electrospinning technique and evaluated for human mesenchymal stem cell (MSC) differentiation along chondrocyte and osteoblast lineages. Slow release of the zinc was observed for all ZnO composite scaffolds. MSC chondrogenic differentiation was promoted on low percentage ZnO composite scaffolds as indicated by the highest collagen type II production and expression of cartilage‐specific genes, while osteogenic differentiation was promoted on high percentage ZnO composite scaffolds as indicated by the highest alkaline phosphatase activity, collagen production, and expression of bone‐specific genes. This study demonstrates the feasibility of ZnO‐containing composites as a potential scaffold for osteochondral tissue engineering.
Osteoarthritis involves the degeneration of articular cartilage and subchondral bone. A biodegradable, fibrous scaffold containing zinc oxide (ZnO) was fabricated and evaluated for its potential use for osteochondral tissue engineering applications. Scaffolds containing a low percentage of ZnO promotes mesenchymal stem cells (MSCs) to become cartilage cells and a high percentage of ZnO promotes MSCs to become bone cells, suggesting a biphasic scaffold design will be needed for osteochondral repair.</description><subject>Alkaline phosphatase</subject><subject>Biodegradability</subject><subject>Biodegradation</subject><subject>Biomedical engineering</subject><subject>Biomedical materials</subject><subject>Biotechnology & Applied Microbiology</subject><subject>Bone growth</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Cartilage diseases</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Chondrocytes</subject><subject>Chondrogenesis</subject><subject>Chondrogenesis - drug effects</subject><subject>Collagen</subject><subject>Collagen (type II)</subject><subject>Degeneration</subject><subject>Differentiation (biology)</subject><subject>Electrochemical Techniques</subject><subject>electrospinning</subject><subject>Feasibility studies</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Insulin</subject><subject>Life Sciences & Biomedicine</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stem Cells - drug effects</subject><subject>Mesenchyme</subject><subject>Nanocomposites - chemistry</subject><subject>Nanoparticles</subject><subject>Osteoarthritis</subject><subject>Osteoblastogenesis</subject><subject>osteochondral differentiation</subject><subject>Osteogenesis - drug effects</subject><subject>Polycaprolactone</subject><subject>Polyesters - chemistry</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Scaffolds</subject><subject>Science & Technology</subject><subject>Stem cells</subject><subject>Subchondral bone</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Zinc</subject><subject>Zinc oxide</subject><subject>Zinc Oxide - chemistry</subject><subject>Zinc Oxide - pharmacology</subject><subject>zinc oxide composite</subject><subject>Zinc oxides</subject><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQQC1ERZfCgT-ALHFCVVp_xHZ8pCsKlSr1Us6RY4-pqyRe7KzK8uuZdpfekCof7LHfjGceIR84O-OMifMhLWfCcCNfkRVn1jRMWPaarBhjupHKimPyttZ7DE2n9RtyLLlqW6vFiowXKQf4WVxwwwj0T5o9zb9TAOrztMk1LUCrdzHmMVS6KXnKeJPrAtnf5TkUN9KQYoQC85LckvJMc6QTVJj93W7CZ2Qn6mEc6ztyFN1Y4f1hPyE_Lr_err831zffrtZfrhsvLZPN0Eml286IljPnNePGCLBRW6tVx0XwOgjVuc45MHYIwrlWaMC5FYRBtkGekE_7utjvry3Upb_P2zLjl72QuKxumUTq857yJddaIPabkiZXdj1n_aPXHr32T16R_XiouB0mCM_kP5EIdHvgAYYcq084PjxjaF61TAkl8MTNOi1PptZ5Oy-YevryVKTPD3QaYff_lvuLq9t9738BI_-jrw</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Khader, Ateka</creator><creator>Arinzeh, Treena Livingston</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-9485-2364</orcidid><orcidid>https://orcid.org/0000-0002-8168-6109</orcidid></search><sort><creationdate>202001</creationdate><title>Biodegradable zinc oxide composite scaffolds promote osteochondral differentiation of mesenchymal stem cells</title><author>Khader, Ateka ; Arinzeh, Treena Livingston</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3903-b83564872410ac601772e9f69965812dc6d258a8aae79bd2aa426e0975edb34d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alkaline phosphatase</topic><topic>Biodegradability</topic><topic>Biodegradation</topic><topic>Biomedical engineering</topic><topic>Biomedical materials</topic><topic>Biotechnology & Applied Microbiology</topic><topic>Bone growth</topic><topic>Cartilage</topic><topic>Cartilage (articular)</topic><topic>Cartilage diseases</topic><topic>Cell differentiation</topic><topic>Cell Differentiation - 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The capacity of articular cartilage to repair and regenerate is limited. A biodegradable, fibrous scaffold containing zinc oxide (ZnO) was fabricated and evaluated for osteochondral tissue engineering applications. ZnO has shown promise for a variety of biomedical applications but has had limited use in tissue engineering. Composite scaffolds consisted of ZnO nanoparticles embedded in slow degrading, polycaprolactone to allow for dissolution of zinc ions over time. Zinc has well‐known insulin‐mimetic properties and can be beneficial for cartilage and bone regeneration. Fibrous ZnO composite scaffolds, having varying concentrations of 1–10 wt.% ZnO, were fabricated using the electrospinning technique and evaluated for human mesenchymal stem cell (MSC) differentiation along chondrocyte and osteoblast lineages. Slow release of the zinc was observed for all ZnO composite scaffolds. MSC chondrogenic differentiation was promoted on low percentage ZnO composite scaffolds as indicated by the highest collagen type II production and expression of cartilage‐specific genes, while osteogenic differentiation was promoted on high percentage ZnO composite scaffolds as indicated by the highest alkaline phosphatase activity, collagen production, and expression of bone‐specific genes. This study demonstrates the feasibility of ZnO‐containing composites as a potential scaffold for osteochondral tissue engineering.
Osteoarthritis involves the degeneration of articular cartilage and subchondral bone. A biodegradable, fibrous scaffold containing zinc oxide (ZnO) was fabricated and evaluated for its potential use for osteochondral tissue engineering applications. Scaffolds containing a low percentage of ZnO promotes mesenchymal stem cells (MSCs) to become cartilage cells and a high percentage of ZnO promotes MSCs to become bone cells, suggesting a biphasic scaffold design will be needed for osteochondral repair.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>31544962</pmid><doi>10.1002/bit.27173</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-9485-2364</orcidid><orcidid>https://orcid.org/0000-0002-8168-6109</orcidid></addata></record> |
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| subjects | Alkaline phosphatase Biodegradability Biodegradation Biomedical engineering Biomedical materials Biotechnology & Applied Microbiology Bone growth Cartilage Cartilage (articular) Cartilage diseases Cell differentiation Cell Differentiation - drug effects Cell Survival - drug effects Cells, Cultured Chondrocytes Chondrogenesis Chondrogenesis - drug effects Collagen Collagen (type II) Degeneration Differentiation (biology) Electrochemical Techniques electrospinning Feasibility studies Gene expression Genes Insulin Life Sciences & Biomedicine Mesenchymal stem cells Mesenchymal Stem Cells - drug effects Mesenchyme Nanocomposites - chemistry Nanoparticles Osteoarthritis Osteoblastogenesis osteochondral differentiation Osteogenesis - drug effects Polycaprolactone Polyesters - chemistry Regeneration Regeneration (physiology) Scaffolds Science & Technology Stem cells Subchondral bone Tissue Engineering Tissue Scaffolds - chemistry Zinc Zinc oxide Zinc Oxide - chemistry Zinc Oxide - pharmacology zinc oxide composite Zinc oxides |
| title | Biodegradable zinc oxide composite scaffolds promote osteochondral differentiation of mesenchymal stem cells |
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