Protective effects of three selected standardized medicinal plant extracts used in Sri Lankan traditional medicine in adriamycin induced nephrotoxic Wistar rats
Abelmoschus moschatus Medik. (family: Malvaceae), Asparagus falcatus (family: Asparagaceae) and Barleria prionitis Linn. (family: Acanthaceae) have been used in the treatment of kidney diseases in Sri Lankan traditional medicine. Besides the traditional use, scientific scrutinization of safe therape...
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| Veröffentlicht in: | Journal of ethnopharmacology 2020-09, Vol.259, p.112933, Article 112933 |
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| creator | Amarasiri, Sachinthi S. Attanayake, Anoja P. Arawwawala, Liyanagae D.A.M. Jayatilaka, Kamani A.P.W. Mudduwa, Lakmini K.B. |
| description | Abelmoschus moschatus Medik. (family: Malvaceae), Asparagus falcatus (family: Asparagaceae) and Barleria prionitis Linn. (family: Acanthaceae) have been used in the treatment of kidney diseases in Sri Lankan traditional medicine. Besides the traditional use, scientific scrutinization of safe therapeutic use of these medicinal plants in the management of kidney diseases has not been reported to date.
The three selected doses of the aqueous extracts of the selected medicinal plants were studied for their protective effects against adriamycin (ADR) induced nephrotoxicity in Wistar rats.
Chemically standardized plant materials were used in the study. The nephroprotective activity of the lyophilized powder of the aqueous refluxed (4hr) leaf extracts of A. moschatus, A. falcatus and the whole plant extract of B. prionitis was investigated in adriamycin (20 mg/kg, ip) induced nephrotoxicity in Wistar rats (n = 6/group). The treatment regimens were initiated 24 h after the induction of nephrotoxicity and continued daily as a single dose for three consecutive days at three selected doses (200, 400 and 600 mg/kg). Fosinopril sodium (0.09 mg/kg) was used as the standard drug. Nephroprotective activity was assessed by estimating the selected biochemical parameters and by the assessment of histopathology on H and E stained sections of the kidney.
The plant extracts at the three selected doses significantly attenuated the elevations in serum creatinine, blood urea nitrogen and the loss of urine total protein in a dose related manner in ADR induced nephrotoxic rats (p |
| doi_str_mv | 10.1016/j.jep.2020.112933 |
| format | Article |
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The three selected doses of the aqueous extracts of the selected medicinal plants were studied for their protective effects against adriamycin (ADR) induced nephrotoxicity in Wistar rats.
Chemically standardized plant materials were used in the study. The nephroprotective activity of the lyophilized powder of the aqueous refluxed (4hr) leaf extracts of A. moschatus, A. falcatus and the whole plant extract of B. prionitis was investigated in adriamycin (20 mg/kg, ip) induced nephrotoxicity in Wistar rats (n = 6/group). The treatment regimens were initiated 24 h after the induction of nephrotoxicity and continued daily as a single dose for three consecutive days at three selected doses (200, 400 and 600 mg/kg). Fosinopril sodium (0.09 mg/kg) was used as the standard drug. Nephroprotective activity was assessed by estimating the selected biochemical parameters and by the assessment of histopathology on H and E stained sections of the kidney.
The plant extracts at the three selected doses significantly attenuated the elevations in serum creatinine, blood urea nitrogen and the loss of urine total protein in a dose related manner in ADR induced nephrotoxic rats (p < 0.001). The serum concentration of albumin and total protein increased significantly (p < 0.001). Histopathological findings corroborated the biochemical evidence of nephroprotective activity. The aqueous extracts of the three selected medicinal plants exerted a relatively high antioxidant activity in vitro.
Evaluation of the protective effects based on biochemical parameters and histopathology assessment revealed that the aqueous leaf extracts of A. moschatus, A. falcatus and the whole plant extract of B. prionitis possess significant nephroprotective activity against ADR induced acute nephrotoxicity. The secondary metabolites present in the plant extracts may attribute to the total antioxidant activities of the selected medicinal plant extracts thereby exerting protective effects against nephrotoxicity in Wistar rats.
[Display omitted]
•A. moschatus, A. falcatus, B. prionitis are widely used in Sri Lankan traditional medicine for kidney diseases.•The aqueous extracts of the selected plants showed protective effects against adriamycin induced acute nephrotoxicity.•Barleria prionitis showed the highest nephroprotective activity in vivo.•The nephroprotective activity might be mediated through the antioxidant properties of the plant extracts.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2020.112933</identifier><identifier>PMID: 32428654</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Abelmoschus ; Abelmoschus moschatus ; Acanthaceae ; Adriamycin induced acute nephrotoxicity ; Animals ; Antioxidants - pharmacology ; Asparagus falcatus ; Asparagus Plant ; Barleria prionitis ; Blood Urea Nitrogen ; Creatinine - blood ; Doxorubicin ; Kidney - drug effects ; Kidney - pathology ; Kidney Diseases - chemically induced ; Kidney Diseases - drug therapy ; Male ; Malvaceae ; Nephroprotective effects ; Plant Extracts - pharmacology ; Plants, Medicinal ; Rats ; Rats, Wistar ; Sri Lanka</subject><ispartof>Journal of ethnopharmacology, 2020-09, Vol.259, p.112933, Article 112933</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-3d470d5670e7ed8baf3e1427cce5be375d18c5533a8a6ed13d8f61926f44f313</citedby><cites>FETCH-LOGICAL-c396t-3d470d5670e7ed8baf3e1427cce5be375d18c5533a8a6ed13d8f61926f44f313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2020.112933$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32428654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amarasiri, Sachinthi S.</creatorcontrib><creatorcontrib>Attanayake, Anoja P.</creatorcontrib><creatorcontrib>Arawwawala, Liyanagae D.A.M.</creatorcontrib><creatorcontrib>Jayatilaka, Kamani A.P.W.</creatorcontrib><creatorcontrib>Mudduwa, Lakmini K.B.</creatorcontrib><title>Protective effects of three selected standardized medicinal plant extracts used in Sri Lankan traditional medicine in adriamycin induced nephrotoxic Wistar rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Abelmoschus moschatus Medik. (family: Malvaceae), Asparagus falcatus (family: Asparagaceae) and Barleria prionitis Linn. (family: Acanthaceae) have been used in the treatment of kidney diseases in Sri Lankan traditional medicine. Besides the traditional use, scientific scrutinization of safe therapeutic use of these medicinal plants in the management of kidney diseases has not been reported to date.
The three selected doses of the aqueous extracts of the selected medicinal plants were studied for their protective effects against adriamycin (ADR) induced nephrotoxicity in Wistar rats.
Chemically standardized plant materials were used in the study. The nephroprotective activity of the lyophilized powder of the aqueous refluxed (4hr) leaf extracts of A. moschatus, A. falcatus and the whole plant extract of B. prionitis was investigated in adriamycin (20 mg/kg, ip) induced nephrotoxicity in Wistar rats (n = 6/group). The treatment regimens were initiated 24 h after the induction of nephrotoxicity and continued daily as a single dose for three consecutive days at three selected doses (200, 400 and 600 mg/kg). Fosinopril sodium (0.09 mg/kg) was used as the standard drug. Nephroprotective activity was assessed by estimating the selected biochemical parameters and by the assessment of histopathology on H and E stained sections of the kidney.
The plant extracts at the three selected doses significantly attenuated the elevations in serum creatinine, blood urea nitrogen and the loss of urine total protein in a dose related manner in ADR induced nephrotoxic rats (p < 0.001). The serum concentration of albumin and total protein increased significantly (p < 0.001). Histopathological findings corroborated the biochemical evidence of nephroprotective activity. The aqueous extracts of the three selected medicinal plants exerted a relatively high antioxidant activity in vitro.
Evaluation of the protective effects based on biochemical parameters and histopathology assessment revealed that the aqueous leaf extracts of A. moschatus, A. falcatus and the whole plant extract of B. prionitis possess significant nephroprotective activity against ADR induced acute nephrotoxicity. The secondary metabolites present in the plant extracts may attribute to the total antioxidant activities of the selected medicinal plant extracts thereby exerting protective effects against nephrotoxicity in Wistar rats.
[Display omitted]
•A. moschatus, A. falcatus, B. prionitis are widely used in Sri Lankan traditional medicine for kidney diseases.•The aqueous extracts of the selected plants showed protective effects against adriamycin induced acute nephrotoxicity.•Barleria prionitis showed the highest nephroprotective activity in vivo.•The nephroprotective activity might be mediated through the antioxidant properties of the plant extracts.</description><subject>Abelmoschus</subject><subject>Abelmoschus moschatus</subject><subject>Acanthaceae</subject><subject>Adriamycin induced acute nephrotoxicity</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Asparagus falcatus</subject><subject>Asparagus Plant</subject><subject>Barleria prionitis</subject><subject>Blood Urea Nitrogen</subject><subject>Creatinine - blood</subject><subject>Doxorubicin</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - drug therapy</subject><subject>Male</subject><subject>Malvaceae</subject><subject>Nephroprotective effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sri Lanka</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1KAzEQhYMotlYfwBvJC2xNNrubLV5J8Q8KCha8DGkyoant7pKkxfo0PqqzVL30KjmZ801mDiGXnI0549X1aryCbpyzHDXPJ0IckSGvZZ7JUopjMmRC1lktCz4gZzGuGGOSF-yUDERe5HVVFkPy9RLaBCb5HVBwDm-Rto6mZQCgEdb4AJbGpBurg_WfKDZgvfGNXtNurZtE4SMF3XPbiFXf0Nfg6Uw377qhWLE--bZ3_3DQW7QNXm_2KFHZrUGwgW6Js7Qf3tA3jz8GGnSK5-TE6XWEi59zROb3d_PpYzZ7fnia3s4yIyZVyoQtJLNlJRlIsPVCOwG8yKUxUC5AyNLy2pSlELrWFVgubO0qPskrVxROcDEi_NDWhDbGAE51wW902CvOVB-2WikMW_Vhq0PYyFwdmG67wOX-iN900XBzMAAOvvMQVDQeGtzWBwxW2db_0_4bUyOUHQ</recordid><startdate>20200915</startdate><enddate>20200915</enddate><creator>Amarasiri, Sachinthi S.</creator><creator>Attanayake, Anoja P.</creator><creator>Arawwawala, Liyanagae D.A.M.</creator><creator>Jayatilaka, Kamani A.P.W.</creator><creator>Mudduwa, Lakmini K.B.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200915</creationdate><title>Protective effects of three selected standardized medicinal plant extracts used in Sri Lankan traditional medicine in adriamycin induced nephrotoxic Wistar rats</title><author>Amarasiri, Sachinthi S. ; Attanayake, Anoja P. ; Arawwawala, Liyanagae D.A.M. ; Jayatilaka, Kamani A.P.W. ; Mudduwa, Lakmini K.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-3d470d5670e7ed8baf3e1427cce5be375d18c5533a8a6ed13d8f61926f44f313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abelmoschus</topic><topic>Abelmoschus moschatus</topic><topic>Acanthaceae</topic><topic>Adriamycin induced acute nephrotoxicity</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Asparagus falcatus</topic><topic>Asparagus Plant</topic><topic>Barleria prionitis</topic><topic>Blood Urea Nitrogen</topic><topic>Creatinine - blood</topic><topic>Doxorubicin</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - drug therapy</topic><topic>Male</topic><topic>Malvaceae</topic><topic>Nephroprotective effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sri Lanka</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amarasiri, Sachinthi S.</creatorcontrib><creatorcontrib>Attanayake, Anoja P.</creatorcontrib><creatorcontrib>Arawwawala, Liyanagae D.A.M.</creatorcontrib><creatorcontrib>Jayatilaka, Kamani A.P.W.</creatorcontrib><creatorcontrib>Mudduwa, Lakmini K.B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amarasiri, Sachinthi S.</au><au>Attanayake, Anoja P.</au><au>Arawwawala, Liyanagae D.A.M.</au><au>Jayatilaka, Kamani A.P.W.</au><au>Mudduwa, Lakmini K.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of three selected standardized medicinal plant extracts used in Sri Lankan traditional medicine in adriamycin induced nephrotoxic Wistar rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2020-09-15</date><risdate>2020</risdate><volume>259</volume><spage>112933</spage><pages>112933-</pages><artnum>112933</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Abelmoschus moschatus Medik. (family: Malvaceae), Asparagus falcatus (family: Asparagaceae) and Barleria prionitis Linn. (family: Acanthaceae) have been used in the treatment of kidney diseases in Sri Lankan traditional medicine. Besides the traditional use, scientific scrutinization of safe therapeutic use of these medicinal plants in the management of kidney diseases has not been reported to date.
The three selected doses of the aqueous extracts of the selected medicinal plants were studied for their protective effects against adriamycin (ADR) induced nephrotoxicity in Wistar rats.
Chemically standardized plant materials were used in the study. The nephroprotective activity of the lyophilized powder of the aqueous refluxed (4hr) leaf extracts of A. moschatus, A. falcatus and the whole plant extract of B. prionitis was investigated in adriamycin (20 mg/kg, ip) induced nephrotoxicity in Wistar rats (n = 6/group). The treatment regimens were initiated 24 h after the induction of nephrotoxicity and continued daily as a single dose for three consecutive days at three selected doses (200, 400 and 600 mg/kg). Fosinopril sodium (0.09 mg/kg) was used as the standard drug. Nephroprotective activity was assessed by estimating the selected biochemical parameters and by the assessment of histopathology on H and E stained sections of the kidney.
The plant extracts at the three selected doses significantly attenuated the elevations in serum creatinine, blood urea nitrogen and the loss of urine total protein in a dose related manner in ADR induced nephrotoxic rats (p < 0.001). The serum concentration of albumin and total protein increased significantly (p < 0.001). Histopathological findings corroborated the biochemical evidence of nephroprotective activity. The aqueous extracts of the three selected medicinal plants exerted a relatively high antioxidant activity in vitro.
Evaluation of the protective effects based on biochemical parameters and histopathology assessment revealed that the aqueous leaf extracts of A. moschatus, A. falcatus and the whole plant extract of B. prionitis possess significant nephroprotective activity against ADR induced acute nephrotoxicity. The secondary metabolites present in the plant extracts may attribute to the total antioxidant activities of the selected medicinal plant extracts thereby exerting protective effects against nephrotoxicity in Wistar rats.
[Display omitted]
•A. moschatus, A. falcatus, B. prionitis are widely used in Sri Lankan traditional medicine for kidney diseases.•The aqueous extracts of the selected plants showed protective effects against adriamycin induced acute nephrotoxicity.•Barleria prionitis showed the highest nephroprotective activity in vivo.•The nephroprotective activity might be mediated through the antioxidant properties of the plant extracts.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>32428654</pmid><doi>10.1016/j.jep.2020.112933</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2020-09, Vol.259, p.112933, Article 112933 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Abelmoschus Abelmoschus moschatus Acanthaceae Adriamycin induced acute nephrotoxicity Animals Antioxidants - pharmacology Asparagus falcatus Asparagus Plant Barleria prionitis Blood Urea Nitrogen Creatinine - blood Doxorubicin Kidney - drug effects Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - drug therapy Male Malvaceae Nephroprotective effects Plant Extracts - pharmacology Plants, Medicinal Rats Rats, Wistar Sri Lanka |
| title | Protective effects of three selected standardized medicinal plant extracts used in Sri Lankan traditional medicine in adriamycin induced nephrotoxic Wistar rats |
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