Increased inflammatory biomarkers and changes in biological rhythms in bipolar disorder: A case-control study

•BD shows changes in biological rhythms.•BD has increase in inflammatory markers.•Increased COX-2 and AA in BD.•Increased IL-6 and TNF-α in BD.•No difference in IL-4, IL-5, IL-10 and IL-33 levels in the BD and control groups. Bipolar Disorder (BD) is a chronic psychiatric disorder characterized by m...

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Veröffentlicht in:Journal of affective disorders 2020-06, Vol.271, p.115-122
Hauptverfasser: Bavaresco, Daniela V., da Rosa, Maria Inês, Uggioni, Maria Laura Rodrigues, Ferraz, Sarah D., Pacheco, Tamires R., Toé, Helena C. Zuehl Dal, da Silveira, Andressa P., Quadros, Luiz F.A., de Souza, Thiani Daminelli, Varela, Roger B., Vieira, Andriele A.S., Pizzol, Felipe Dal, Valvassori, Samira S., Quevedo, João
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container_end_page 122
container_issue
container_start_page 115
container_title Journal of affective disorders
container_volume 271
creator Bavaresco, Daniela V.
da Rosa, Maria Inês
Uggioni, Maria Laura Rodrigues
Ferraz, Sarah D.
Pacheco, Tamires R.
Toé, Helena C. Zuehl Dal
da Silveira, Andressa P.
Quadros, Luiz F.A.
de Souza, Thiani Daminelli
Varela, Roger B.
Vieira, Andriele A.S.
Pizzol, Felipe Dal
Valvassori, Samira S.
Quevedo, João
description •BD shows changes in biological rhythms.•BD has increase in inflammatory markers.•Increased COX-2 and AA in BD.•Increased IL-6 and TNF-α in BD.•No difference in IL-4, IL-5, IL-10 and IL-33 levels in the BD and control groups. Bipolar Disorder (BD) is a chronic psychiatric disorder characterized by mood disturbances that include depressive, manic, and hypomanic episodes. Despite the severity of the symptoms, there is still a gap in the literature on the precise neurobiology and treatment of BD. The investigations of inflammatory changes in BD has increased in the last decade, evincing the importance of its role in the pathophysiology of the disorder. The present study aimed to investigate the inflammatory role in BD, through the evaluation of biomarkers and their relation to biological rhythms. It was conducted a case-control study that included 36 BD and 46 healthy controls (HC). The Cyclooxygenase 2 (COX-2) enzyme, Arachidonic Acid (AA), interleukins (IL) IL-4, IL-5, IL-6, IL-10, IL-33, and Tumor Necrosis Factor Alpha (TNF-α) in the serum of individuals. It also was administered the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN) to the BD and healthy control groups. Results: The results indicated that the individuals with BD showed increased COX-2, AA, IL-6, and TNF-α levels in comparison to the HC without psychiatric disorders, as well as significant commitments in all domains evaluated by BRIAN. Uncontrolled pharmacotherapy used by the included bipolar participants, which had important effects on participants’ inflammatory systems and the lack of cases with bipolar manic episodes. The results of the present study reaffirm that inflammation has an important role in BD, as well as the significant changes in biological rhythms. It is still necessary to better characterize the inflammatory pathway of AA.
doi_str_mv 10.1016/j.jad.2020.03.073
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Zuehl Dal ; da Silveira, Andressa P. ; Quadros, Luiz F.A. ; de Souza, Thiani Daminelli ; Varela, Roger B. ; Vieira, Andriele A.S. ; Pizzol, Felipe Dal ; Valvassori, Samira S. ; Quevedo, João</creator><creatorcontrib>Bavaresco, Daniela V. ; da Rosa, Maria Inês ; Uggioni, Maria Laura Rodrigues ; Ferraz, Sarah D. ; Pacheco, Tamires R. ; Toé, Helena C. Zuehl Dal ; da Silveira, Andressa P. ; Quadros, Luiz F.A. ; de Souza, Thiani Daminelli ; Varela, Roger B. ; Vieira, Andriele A.S. ; Pizzol, Felipe Dal ; Valvassori, Samira S. ; Quevedo, João</creatorcontrib><description>•BD shows changes in biological rhythms.•BD has increase in inflammatory markers.•Increased COX-2 and AA in BD.•Increased IL-6 and TNF-α in BD.•No difference in IL-4, IL-5, IL-10 and IL-33 levels in the BD and control groups. Bipolar Disorder (BD) is a chronic psychiatric disorder characterized by mood disturbances that include depressive, manic, and hypomanic episodes. Despite the severity of the symptoms, there is still a gap in the literature on the precise neurobiology and treatment of BD. The investigations of inflammatory changes in BD has increased in the last decade, evincing the importance of its role in the pathophysiology of the disorder. The present study aimed to investigate the inflammatory role in BD, through the evaluation of biomarkers and their relation to biological rhythms. It was conducted a case-control study that included 36 BD and 46 healthy controls (HC). The Cyclooxygenase 2 (COX-2) enzyme, Arachidonic Acid (AA), interleukins (IL) IL-4, IL-5, IL-6, IL-10, IL-33, and Tumor Necrosis Factor Alpha (TNF-α) in the serum of individuals. It also was administered the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN) to the BD and healthy control groups. Results: The results indicated that the individuals with BD showed increased COX-2, AA, IL-6, and TNF-α levels in comparison to the HC without psychiatric disorders, as well as significant commitments in all domains evaluated by BRIAN. Uncontrolled pharmacotherapy used by the included bipolar participants, which had important effects on participants’ inflammatory systems and the lack of cases with bipolar manic episodes. The results of the present study reaffirm that inflammation has an important role in BD, as well as the significant changes in biological rhythms. It is still necessary to better characterize the inflammatory pathway of AA.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2020.03.073</identifier><identifier>PMID: 32479306</identifier><language>eng</language><publisher>AMSTERDAM: Elsevier B.V</publisher><subject>Arachidonic acid ; Biological rhythms ; Biomarkers ; Bipolar Disorder ; Case-Control Studies ; Clinical Neurology ; Cyclooxygenase 2 ; Humans ; Inflammation ; Interleukin ; Life Sciences &amp; Biomedicine ; Neurosciences &amp; Neurology ; Periodicity ; Psychiatry ; Science &amp; Technology ; Tumor Necrosis Factor-alpha</subject><ispartof>Journal of affective disorders, 2020-06, Vol.271, p.115-122</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>16</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000538771000015</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c353t-d02ba59443c485e364043e26be6eaa679f19793af1b669a070aa4bcb408049f53</citedby><cites>FETCH-LOGICAL-c353t-d02ba59443c485e364043e26be6eaa679f19793af1b669a070aa4bcb408049f53</cites><orcidid>0000-0001-8883-287X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2020.03.073$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,28255,28256,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32479306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bavaresco, Daniela V.</creatorcontrib><creatorcontrib>da Rosa, Maria Inês</creatorcontrib><creatorcontrib>Uggioni, Maria Laura Rodrigues</creatorcontrib><creatorcontrib>Ferraz, Sarah D.</creatorcontrib><creatorcontrib>Pacheco, Tamires R.</creatorcontrib><creatorcontrib>Toé, Helena C. Zuehl Dal</creatorcontrib><creatorcontrib>da Silveira, Andressa P.</creatorcontrib><creatorcontrib>Quadros, Luiz F.A.</creatorcontrib><creatorcontrib>de Souza, Thiani Daminelli</creatorcontrib><creatorcontrib>Varela, Roger B.</creatorcontrib><creatorcontrib>Vieira, Andriele A.S.</creatorcontrib><creatorcontrib>Pizzol, Felipe Dal</creatorcontrib><creatorcontrib>Valvassori, Samira S.</creatorcontrib><creatorcontrib>Quevedo, João</creatorcontrib><title>Increased inflammatory biomarkers and changes in biological rhythms in bipolar disorder: A case-control study</title><title>Journal of affective disorders</title><addtitle>J AFFECT DISORDERS</addtitle><addtitle>J Affect Disord</addtitle><description>•BD shows changes in biological rhythms.•BD has increase in inflammatory markers.•Increased COX-2 and AA in BD.•Increased IL-6 and TNF-α in BD.•No difference in IL-4, IL-5, IL-10 and IL-33 levels in the BD and control groups. Bipolar Disorder (BD) is a chronic psychiatric disorder characterized by mood disturbances that include depressive, manic, and hypomanic episodes. Despite the severity of the symptoms, there is still a gap in the literature on the precise neurobiology and treatment of BD. The investigations of inflammatory changes in BD has increased in the last decade, evincing the importance of its role in the pathophysiology of the disorder. The present study aimed to investigate the inflammatory role in BD, through the evaluation of biomarkers and their relation to biological rhythms. It was conducted a case-control study that included 36 BD and 46 healthy controls (HC). The Cyclooxygenase 2 (COX-2) enzyme, Arachidonic Acid (AA), interleukins (IL) IL-4, IL-5, IL-6, IL-10, IL-33, and Tumor Necrosis Factor Alpha (TNF-α) in the serum of individuals. It also was administered the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN) to the BD and healthy control groups. Results: The results indicated that the individuals with BD showed increased COX-2, AA, IL-6, and TNF-α levels in comparison to the HC without psychiatric disorders, as well as significant commitments in all domains evaluated by BRIAN. Uncontrolled pharmacotherapy used by the included bipolar participants, which had important effects on participants’ inflammatory systems and the lack of cases with bipolar manic episodes. The results of the present study reaffirm that inflammation has an important role in BD, as well as the significant changes in biological rhythms. 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Zuehl Dal</au><au>da Silveira, Andressa P.</au><au>Quadros, Luiz F.A.</au><au>de Souza, Thiani Daminelli</au><au>Varela, Roger B.</au><au>Vieira, Andriele A.S.</au><au>Pizzol, Felipe Dal</au><au>Valvassori, Samira S.</au><au>Quevedo, João</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased inflammatory biomarkers and changes in biological rhythms in bipolar disorder: A case-control study</atitle><jtitle>Journal of affective disorders</jtitle><stitle>J AFFECT DISORDERS</stitle><addtitle>J Affect Disord</addtitle><date>2020-06-15</date><risdate>2020</risdate><volume>271</volume><spage>115</spage><epage>122</epage><pages>115-122</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>•BD shows changes in biological rhythms.•BD has increase in inflammatory markers.•Increased COX-2 and AA in BD.•Increased IL-6 and TNF-α in BD.•No difference in IL-4, IL-5, IL-10 and IL-33 levels in the BD and control groups. Bipolar Disorder (BD) is a chronic psychiatric disorder characterized by mood disturbances that include depressive, manic, and hypomanic episodes. Despite the severity of the symptoms, there is still a gap in the literature on the precise neurobiology and treatment of BD. The investigations of inflammatory changes in BD has increased in the last decade, evincing the importance of its role in the pathophysiology of the disorder. The present study aimed to investigate the inflammatory role in BD, through the evaluation of biomarkers and their relation to biological rhythms. It was conducted a case-control study that included 36 BD and 46 healthy controls (HC). The Cyclooxygenase 2 (COX-2) enzyme, Arachidonic Acid (AA), interleukins (IL) IL-4, IL-5, IL-6, IL-10, IL-33, and Tumor Necrosis Factor Alpha (TNF-α) in the serum of individuals. It also was administered the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN) to the BD and healthy control groups. Results: The results indicated that the individuals with BD showed increased COX-2, AA, IL-6, and TNF-α levels in comparison to the HC without psychiatric disorders, as well as significant commitments in all domains evaluated by BRIAN. Uncontrolled pharmacotherapy used by the included bipolar participants, which had important effects on participants’ inflammatory systems and the lack of cases with bipolar manic episodes. The results of the present study reaffirm that inflammation has an important role in BD, as well as the significant changes in biological rhythms. It is still necessary to better characterize the inflammatory pathway of AA.</abstract><cop>AMSTERDAM</cop><pub>Elsevier B.V</pub><pmid>32479306</pmid><doi>10.1016/j.jad.2020.03.073</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8883-287X</orcidid></addata></record>
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subjects Arachidonic acid
Biological rhythms
Biomarkers
Bipolar Disorder
Case-Control Studies
Clinical Neurology
Cyclooxygenase 2
Humans
Inflammation
Interleukin
Life Sciences & Biomedicine
Neurosciences & Neurology
Periodicity
Psychiatry
Science & Technology
Tumor Necrosis Factor-alpha
title Increased inflammatory biomarkers and changes in biological rhythms in bipolar disorder: A case-control study
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