Targeting Intracellular Pathogenic Bacteria Through N-Terminal Modification of Cationic Amphiphilic Polyproline Helices
Intracellular pathogens can thrive within mammalian cells and are inaccessible to many antimicrobial agents. Herein, we present a facile method of enhancing the cell penetrating and antibacterial properties of cationic amphiphilic polyproline helices (CAPHs) with modifications to the hydrophobic moi...
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| Veröffentlicht in: | Journal of organic chemistry 2020-06, Vol.85 (11), p.7468-7475 |
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| Sprache: | eng |
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| container_end_page | 7475 |
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| container_issue | 11 |
| container_start_page | 7468 |
| container_title | Journal of organic chemistry |
| container_volume | 85 |
| creator | Dietsche, Thomas A Eldesouky, Hassan E Zeiders, Samantha M Seleem, Mohamed N Chmielewski, Jean |
| description | Intracellular pathogens can thrive within mammalian cells and are inaccessible to many antimicrobial agents. Herein, we present a facile method of enhancing the cell penetrating and antibacterial properties of cationic amphiphilic polyproline helices (CAPHs) with modifications to the hydrophobic moiety at the N-terminus. These altered CAPHs display superior cell penetration within macrophage cells, and in some cases, minimal cytotoxicity. Furthermore, one CAPH,
exhibited excellent antibacterial activity against multiple strains of pathogenic bacteria and promoted the clearance of intracellular
within macrophages. |
| doi_str_mv | 10.1021/acs.joc.0c00871 |
| format | Article |
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| source | ACS Publications |
| title | Targeting Intracellular Pathogenic Bacteria Through N-Terminal Modification of Cationic Amphiphilic Polyproline Helices |
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