Self-Assembly of Porphyrin-Containing Metalla-Assemblies and Cancer Photodynamic Therapy
In this report, we describe the synthesis of two porphyrin-containing Pt(II) supramolecular assemblies via coordination-driven self-assembly. X-ray crystallographic analysis on one assembly reveals that the metalla-assembly formation imposes large interchromophore distances, leading to a higher O-1(...
Gespeichert in:
| Veröffentlicht in: | Inorganic chemistry 2020-06, Vol.59 (11), p.7380-7388 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7388 |
|---|---|
| container_issue | 11 |
| container_start_page | 7380 |
| container_title | Inorganic chemistry |
| container_volume | 59 |
| creator | Jiang, Xin Zhou, Zhixuan Yang, Huang Shan, Chuan Yu, Hao Wojtas, Lukasz Zhang, Mingming Mao, Zhengwei Wang, Ming Stang, Peter J. |
| description | In this report, we describe the synthesis of two porphyrin-containing Pt(II) supramolecular assemblies via coordination-driven self-assembly. X-ray crystallographic analysis on one assembly reveals that the metalla-assembly formation imposes large interchromophore distances, leading to a higher O-1(2) generation efficiency, relative to the corresponding small molecular precursors. The metalla-assemblies were examined as photosensitizers for photodynamic therapy as the potential reduction of the unfavorable self-aggregation phenomenon. In vivo and in vitro investigations demonstrate that the metalla-assemblies exhibit enhanced anticancer activity with minimal dose requirement and side effects comparable to the small molecule precursors. Thus, our work demonstrates that self-assembly provides a promising methodology for enhancing the therapeutic effectiveness of anticancer agents. |
| doi_str_mv | 10.1021/acs.inorgchem.9b02775 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000538336400003</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2343035646</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-15feb63d6a8ee7e18ab5a181a52fa99d688c8852a0835364fa55e249367368233</originalsourceid><addsrcrecordid>eNqNkF1L7DAQhoMc0fXjJyi9PCBd89Fk00sp56igKKjgXZmmUzfSJmvSRfrvjey6117NXDzvzMtDyBmjc0Y5uwQT59b58GaWOMzLhvLFQu6RGZOc5pLR1z9kRmnamVLlITmK8Z1SWopCHZBDwUrFWCFn5PUJ-y6_ihGHpp8y32WPPqyWU7Aur7wbwTrr3rJ7HKHv4Qe0GDNwbVaBMxiyx6UffTs5GKzJnpcYYDWdkP0O-oin23lMXv7_e65u8ruH69vq6i43BedjzmSHjRKtAo24QKahkcA0A8k7KMtWaW20lhyoFlKoogMpkRelUAuhNBfimPzd3F0F_7HGONaDjQZTWYd-HWsuCkGFVIVKqNygJvgYA3b1KtgBwlQzWn9LrZPUeie13kpNufPti3UzYLtL_VhMwMUG-MTGd9FYTFp2WNIuhRapfNrod2P9e7qyI4zWu8qv3Si-AMvAl5s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2343035646</pqid></control><display><type>article</type><title>Self-Assembly of Porphyrin-Containing Metalla-Assemblies and Cancer Photodynamic Therapy</title><source>MEDLINE</source><source>ACS Publications</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Jiang, Xin ; Zhou, Zhixuan ; Yang, Huang ; Shan, Chuan ; Yu, Hao ; Wojtas, Lukasz ; Zhang, Mingming ; Mao, Zhengwei ; Wang, Ming ; Stang, Peter J.</creator><creatorcontrib>Jiang, Xin ; Zhou, Zhixuan ; Yang, Huang ; Shan, Chuan ; Yu, Hao ; Wojtas, Lukasz ; Zhang, Mingming ; Mao, Zhengwei ; Wang, Ming ; Stang, Peter J.</creatorcontrib><description>In this report, we describe the synthesis of two porphyrin-containing Pt(II) supramolecular assemblies via coordination-driven self-assembly. X-ray crystallographic analysis on one assembly reveals that the metalla-assembly formation imposes large interchromophore distances, leading to a higher O-1(2) generation efficiency, relative to the corresponding small molecular precursors. The metalla-assemblies were examined as photosensitizers for photodynamic therapy as the potential reduction of the unfavorable self-aggregation phenomenon. In vivo and in vitro investigations demonstrate that the metalla-assemblies exhibit enhanced anticancer activity with minimal dose requirement and side effects comparable to the small molecule precursors. Thus, our work demonstrates that self-assembly provides a promising methodology for enhancing the therapeutic effectiveness of anticancer agents.</description><identifier>ISSN: 0020-1669</identifier><identifier>ISSN: 1520-510X</identifier><identifier>EISSN: 1520-510X</identifier><identifier>DOI: 10.1021/acs.inorgchem.9b02775</identifier><identifier>PMID: 31961145</identifier><language>eng</language><publisher>WASHINGTON: Amer Chemical Soc</publisher><subject>Animals ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Chemistry ; Chemistry, Inorganic & Nuclear ; Coordination Complexes - chemical synthesis ; Coordination Complexes - chemistry ; Coordination Complexes - pharmacology ; Drug Screening Assays, Antitumor ; Female ; Mice ; Organoplatinum Compounds - chemical synthesis ; Organoplatinum Compounds - chemistry ; Organoplatinum Compounds - pharmacology ; Photochemotherapy ; Photosensitizing Agents - chemical synthesis ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - pharmacology ; Physical Sciences ; Porphyrins - chemistry ; Porphyrins - pharmacology ; Science & Technology</subject><ispartof>Inorganic chemistry, 2020-06, Vol.59 (11), p.7380-7388</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>49</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000538336400003</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c422t-15feb63d6a8ee7e18ab5a181a52fa99d688c8852a0835364fa55e249367368233</citedby><cites>FETCH-LOGICAL-c422t-15feb63d6a8ee7e18ab5a181a52fa99d688c8852a0835364fa55e249367368233</cites><orcidid>0000-0003-3156-7811 ; 0000-0002-5332-0804 ; 0000-0001-8295-5860 ; 0000-0002-2307-0576 ; 0000-0001-7990-2856 ; 0000-0002-5173-1335</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2766,27929,27930,28253</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31961145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Xin</creatorcontrib><creatorcontrib>Zhou, Zhixuan</creatorcontrib><creatorcontrib>Yang, Huang</creatorcontrib><creatorcontrib>Shan, Chuan</creatorcontrib><creatorcontrib>Yu, Hao</creatorcontrib><creatorcontrib>Wojtas, Lukasz</creatorcontrib><creatorcontrib>Zhang, Mingming</creatorcontrib><creatorcontrib>Mao, Zhengwei</creatorcontrib><creatorcontrib>Wang, Ming</creatorcontrib><creatorcontrib>Stang, Peter J.</creatorcontrib><title>Self-Assembly of Porphyrin-Containing Metalla-Assemblies and Cancer Photodynamic Therapy</title><title>Inorganic chemistry</title><addtitle>INORG CHEM</addtitle><addtitle>Inorg Chem</addtitle><description>In this report, we describe the synthesis of two porphyrin-containing Pt(II) supramolecular assemblies via coordination-driven self-assembly. X-ray crystallographic analysis on one assembly reveals that the metalla-assembly formation imposes large interchromophore distances, leading to a higher O-1(2) generation efficiency, relative to the corresponding small molecular precursors. The metalla-assemblies were examined as photosensitizers for photodynamic therapy as the potential reduction of the unfavorable self-aggregation phenomenon. In vivo and in vitro investigations demonstrate that the metalla-assemblies exhibit enhanced anticancer activity with minimal dose requirement and side effects comparable to the small molecule precursors. Thus, our work demonstrates that self-assembly provides a promising methodology for enhancing the therapeutic effectiveness of anticancer agents.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Chemistry</subject><subject>Chemistry, Inorganic & Nuclear</subject><subject>Coordination Complexes - chemical synthesis</subject><subject>Coordination Complexes - chemistry</subject><subject>Coordination Complexes - pharmacology</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Female</subject><subject>Mice</subject><subject>Organoplatinum Compounds - chemical synthesis</subject><subject>Organoplatinum Compounds - chemistry</subject><subject>Organoplatinum Compounds - pharmacology</subject><subject>Photochemotherapy</subject><subject>Photosensitizing Agents - chemical synthesis</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Physical Sciences</subject><subject>Porphyrins - chemistry</subject><subject>Porphyrins - pharmacology</subject><subject>Science & Technology</subject><issn>0020-1669</issn><issn>1520-510X</issn><issn>1520-510X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkF1L7DAQhoMc0fXjJyi9PCBd89Fk00sp56igKKjgXZmmUzfSJmvSRfrvjey6117NXDzvzMtDyBmjc0Y5uwQT59b58GaWOMzLhvLFQu6RGZOc5pLR1z9kRmnamVLlITmK8Z1SWopCHZBDwUrFWCFn5PUJ-y6_ihGHpp8y32WPPqyWU7Aur7wbwTrr3rJ7HKHv4Qe0GDNwbVaBMxiyx6UffTs5GKzJnpcYYDWdkP0O-oin23lMXv7_e65u8ruH69vq6i43BedjzmSHjRKtAo24QKahkcA0A8k7KMtWaW20lhyoFlKoogMpkRelUAuhNBfimPzd3F0F_7HGONaDjQZTWYd-HWsuCkGFVIVKqNygJvgYA3b1KtgBwlQzWn9LrZPUeie13kpNufPti3UzYLtL_VhMwMUG-MTGd9FYTFp2WNIuhRapfNrod2P9e7qyI4zWu8qv3Si-AMvAl5s</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Jiang, Xin</creator><creator>Zhou, Zhixuan</creator><creator>Yang, Huang</creator><creator>Shan, Chuan</creator><creator>Yu, Hao</creator><creator>Wojtas, Lukasz</creator><creator>Zhang, Mingming</creator><creator>Mao, Zhengwei</creator><creator>Wang, Ming</creator><creator>Stang, Peter J.</creator><general>Amer Chemical Soc</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3156-7811</orcidid><orcidid>https://orcid.org/0000-0002-5332-0804</orcidid><orcidid>https://orcid.org/0000-0001-8295-5860</orcidid><orcidid>https://orcid.org/0000-0002-2307-0576</orcidid><orcidid>https://orcid.org/0000-0001-7990-2856</orcidid><orcidid>https://orcid.org/0000-0002-5173-1335</orcidid></search><sort><creationdate>20200601</creationdate><title>Self-Assembly of Porphyrin-Containing Metalla-Assemblies and Cancer Photodynamic Therapy</title><author>Jiang, Xin ; Zhou, Zhixuan ; Yang, Huang ; Shan, Chuan ; Yu, Hao ; Wojtas, Lukasz ; Zhang, Mingming ; Mao, Zhengwei ; Wang, Ming ; Stang, Peter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-15feb63d6a8ee7e18ab5a181a52fa99d688c8852a0835364fa55e249367368233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Chemistry</topic><topic>Chemistry, Inorganic & Nuclear</topic><topic>Coordination Complexes - chemical synthesis</topic><topic>Coordination Complexes - chemistry</topic><topic>Coordination Complexes - pharmacology</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Female</topic><topic>Mice</topic><topic>Organoplatinum Compounds - chemical synthesis</topic><topic>Organoplatinum Compounds - chemistry</topic><topic>Organoplatinum Compounds - pharmacology</topic><topic>Photochemotherapy</topic><topic>Photosensitizing Agents - chemical synthesis</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Physical Sciences</topic><topic>Porphyrins - chemistry</topic><topic>Porphyrins - pharmacology</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Xin</creatorcontrib><creatorcontrib>Zhou, Zhixuan</creatorcontrib><creatorcontrib>Yang, Huang</creatorcontrib><creatorcontrib>Shan, Chuan</creatorcontrib><creatorcontrib>Yu, Hao</creatorcontrib><creatorcontrib>Wojtas, Lukasz</creatorcontrib><creatorcontrib>Zhang, Mingming</creatorcontrib><creatorcontrib>Mao, Zhengwei</creatorcontrib><creatorcontrib>Wang, Ming</creatorcontrib><creatorcontrib>Stang, Peter J.</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Xin</au><au>Zhou, Zhixuan</au><au>Yang, Huang</au><au>Shan, Chuan</au><au>Yu, Hao</au><au>Wojtas, Lukasz</au><au>Zhang, Mingming</au><au>Mao, Zhengwei</au><au>Wang, Ming</au><au>Stang, Peter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-Assembly of Porphyrin-Containing Metalla-Assemblies and Cancer Photodynamic Therapy</atitle><jtitle>Inorganic chemistry</jtitle><stitle>INORG CHEM</stitle><addtitle>Inorg Chem</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>59</volume><issue>11</issue><spage>7380</spage><epage>7388</epage><pages>7380-7388</pages><issn>0020-1669</issn><issn>1520-510X</issn><eissn>1520-510X</eissn><abstract>In this report, we describe the synthesis of two porphyrin-containing Pt(II) supramolecular assemblies via coordination-driven self-assembly. X-ray crystallographic analysis on one assembly reveals that the metalla-assembly formation imposes large interchromophore distances, leading to a higher O-1(2) generation efficiency, relative to the corresponding small molecular precursors. The metalla-assemblies were examined as photosensitizers for photodynamic therapy as the potential reduction of the unfavorable self-aggregation phenomenon. In vivo and in vitro investigations demonstrate that the metalla-assemblies exhibit enhanced anticancer activity with minimal dose requirement and side effects comparable to the small molecule precursors. Thus, our work demonstrates that self-assembly provides a promising methodology for enhancing the therapeutic effectiveness of anticancer agents.</abstract><cop>WASHINGTON</cop><pub>Amer Chemical Soc</pub><pmid>31961145</pmid><doi>10.1021/acs.inorgchem.9b02775</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3156-7811</orcidid><orcidid>https://orcid.org/0000-0002-5332-0804</orcidid><orcidid>https://orcid.org/0000-0001-8295-5860</orcidid><orcidid>https://orcid.org/0000-0002-2307-0576</orcidid><orcidid>https://orcid.org/0000-0001-7990-2856</orcidid><orcidid>https://orcid.org/0000-0002-5173-1335</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-1669 |
| ispartof | Inorganic chemistry, 2020-06, Vol.59 (11), p.7380-7388 |
| issn | 0020-1669 1520-510X 1520-510X |
| language | eng |
| recordid | cdi_webofscience_primary_000538336400003 |
| source | MEDLINE; ACS Publications; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemistry Chemistry, Inorganic & Nuclear Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Drug Screening Assays, Antitumor Female Mice Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Photochemotherapy Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Physical Sciences Porphyrins - chemistry Porphyrins - pharmacology Science & Technology |
| title | Self-Assembly of Porphyrin-Containing Metalla-Assemblies and Cancer Photodynamic Therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T07%3A16%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Self-Assembly%20of%20Porphyrin-Containing%20Metalla-Assemblies%20and%20Cancer%20Photodynamic%20Therapy&rft.jtitle=Inorganic%20chemistry&rft.au=Jiang,%20Xin&rft.date=2020-06-01&rft.volume=59&rft.issue=11&rft.spage=7380&rft.epage=7388&rft.pages=7380-7388&rft.issn=0020-1669&rft.eissn=1520-510X&rft_id=info:doi/10.1021/acs.inorgchem.9b02775&rft_dat=%3Cproquest_webof%3E2343035646%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2343035646&rft_id=info:pmid/31961145&rfr_iscdi=true |