Antidepressant Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice
Depression is an emotional disorder that causes mental and physical changes, and has limited pharmacotherapy. Tannic acid (TA) is a polyphenol with previously described antioxidant and neuroprotective properties. The aim of this study was to evaluate the effects of TA on lipopolysaccharide (LPS)-ind...
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| Veröffentlicht in: | Neurochemical research 2020-09, Vol.45 (9), p.2032-2043 |
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| creator | Luduvico, Karina Pereira Spohr, Luiza Soares, Mayara Sandrielly Pereira Teixeira, Fernanda Cardoso de Farias, Alana Seixas Bona, Natália Pontes Pedra, Nathalia Stark de Oliveira Campello Felix, Anelize Spanevello, Roselia Maria Stefanello, Francieli Moro |
| description | Depression is an emotional disorder that causes mental and physical changes, and has limited pharmacotherapy. Tannic acid (TA) is a polyphenol with previously described antioxidant and neuroprotective properties. The aim of this study was to evaluate the effects of TA on lipopolysaccharide (LPS)-induced depressive-like behavior, as well as oxidative stress parameters and TNF-α levels in the brains of mice. Animals were pretreated once daily, with TA (30 or 60 mg/kg), fluoxetine (20 mg/kg) or vehicle for 7 days. On the 7th day, the animals received a single injection of LPS (830 μg/kg). After 24 h, open field, forced swimming, tail suspension, and splash tests were conducted. The endotoxin induced depressive-like behavior in these mice and this was attenuated by TA. In the cerebral cortex, hippocampus, and striatum, LPS increased lipid peroxidation and reactive oxygen species production, and this was also prevented by TA administration. TA treatment also prevented a decrease in catalase activity within the striatum. Further, LPS administration caused increased levels of TNF-α in all brain structures, and this was prevented in the cortex by TA treatment. In conclusion, TA shows many neuroprotective properties, with demonstrated antioxidant, anti-inflammatory and antidepressant effects in this animal model of acute depressive-like behavior. Therefore, this compound could provide an alternative therapeutic approach for the treatment of depression. |
| doi_str_mv | 10.1007/s11064-020-03064-5 |
| format | Article |
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Tannic acid (TA) is a polyphenol with previously described antioxidant and neuroprotective properties. The aim of this study was to evaluate the effects of TA on lipopolysaccharide (LPS)-induced depressive-like behavior, as well as oxidative stress parameters and TNF-α levels in the brains of mice. Animals were pretreated once daily, with TA (30 or 60 mg/kg), fluoxetine (20 mg/kg) or vehicle for 7 days. On the 7th day, the animals received a single injection of LPS (830 μg/kg). After 24 h, open field, forced swimming, tail suspension, and splash tests were conducted. The endotoxin induced depressive-like behavior in these mice and this was attenuated by TA. In the cerebral cortex, hippocampus, and striatum, LPS increased lipid peroxidation and reactive oxygen species production, and this was also prevented by TA administration. TA treatment also prevented a decrease in catalase activity within the striatum. Further, LPS administration caused increased levels of TNF-α in all brain structures, and this was prevented in the cortex by TA treatment. In conclusion, TA shows many neuroprotective properties, with demonstrated antioxidant, anti-inflammatory and antidepressant effects in this animal model of acute depressive-like behavior. Therefore, this compound could provide an alternative therapeutic approach for the treatment of depression.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-020-03064-5</identifier><identifier>PMID: 32500408</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acids ; Animal behavior ; Animal cognition ; Animal models ; Animals ; Antidepressants ; Antioxidants ; Behavior ; Biochemistry ; Biochemistry & Molecular Biology ; Biomedical and Life Sciences ; Biomedicine ; Brain research ; Catalase ; Cell Biology ; Cerebral cortex ; Cytokines ; Drug therapy ; Endotoxins ; Fluoxetine ; Free radicals ; Inflammation ; Laboratory animals ; Life Sciences & Biomedicine ; Lipid peroxidation ; Lipids ; Lipopolysaccharides ; Mental depression ; Neostriatum ; Neurochemistry ; Neurology ; Neuroprotection ; Neurosciences ; Neurosciences & Neurology ; Original Paper ; Oxidative stress ; Peroxidation ; Polyphenols ; Reactive oxygen species ; Science & Technology ; Tannic acid ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Neurochemical research, 2020-09, Vol.45 (9), p.2032-2043</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>17</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000538009700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c352t-a91a74f3b435bb28b158937c6d1352ca3ab17a8cd06fdf619cab08e5f99adeab3</citedby><cites>FETCH-LOGICAL-c352t-a91a74f3b435bb28b158937c6d1352ca3ab17a8cd06fdf619cab08e5f99adeab3</cites><orcidid>0000-0001-5945-3723 ; 0000-0002-5117-2000</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-020-03064-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-020-03064-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,28255,41495,42564,51326</link.rule.ids></links><search><creatorcontrib>Luduvico, Karina Pereira</creatorcontrib><creatorcontrib>Spohr, Luiza</creatorcontrib><creatorcontrib>Soares, Mayara Sandrielly Pereira</creatorcontrib><creatorcontrib>Teixeira, Fernanda Cardoso</creatorcontrib><creatorcontrib>de Farias, Alana Seixas</creatorcontrib><creatorcontrib>Bona, Natália Pontes</creatorcontrib><creatorcontrib>Pedra, Nathalia Stark</creatorcontrib><creatorcontrib>de Oliveira Campello Felix, Anelize</creatorcontrib><creatorcontrib>Spanevello, Roselia Maria</creatorcontrib><creatorcontrib>Stefanello, Francieli Moro</creatorcontrib><title>Antidepressant Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>NEUROCHEM RES</addtitle><description>Depression is an emotional disorder that causes mental and physical changes, and has limited pharmacotherapy. Tannic acid (TA) is a polyphenol with previously described antioxidant and neuroprotective properties. The aim of this study was to evaluate the effects of TA on lipopolysaccharide (LPS)-induced depressive-like behavior, as well as oxidative stress parameters and TNF-α levels in the brains of mice. Animals were pretreated once daily, with TA (30 or 60 mg/kg), fluoxetine (20 mg/kg) or vehicle for 7 days. On the 7th day, the animals received a single injection of LPS (830 μg/kg). After 24 h, open field, forced swimming, tail suspension, and splash tests were conducted. The endotoxin induced depressive-like behavior in these mice and this was attenuated by TA. In the cerebral cortex, hippocampus, and striatum, LPS increased lipid peroxidation and reactive oxygen species production, and this was also prevented by TA administration. TA treatment also prevented a decrease in catalase activity within the striatum. Further, LPS administration caused increased levels of TNF-α in all brain structures, and this was prevented in the cortex by TA treatment. In conclusion, TA shows many neuroprotective properties, with demonstrated antioxidant, anti-inflammatory and antidepressant effects in this animal model of acute depressive-like behavior. Therefore, this compound could provide an alternative therapeutic approach for the treatment of depression.</description><subject>Acids</subject><subject>Animal behavior</subject><subject>Animal cognition</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antidepressants</subject><subject>Antioxidants</subject><subject>Behavior</subject><subject>Biochemistry</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain research</subject><subject>Catalase</subject><subject>Cell Biology</subject><subject>Cerebral cortex</subject><subject>Cytokines</subject><subject>Drug therapy</subject><subject>Endotoxins</subject><subject>Fluoxetine</subject><subject>Free radicals</subject><subject>Inflammation</subject><subject>Laboratory animals</subject><subject>Life Sciences & Biomedicine</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Lipopolysaccharides</subject><subject>Mental depression</subject><subject>Neostriatum</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neuroprotection</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Original Paper</subject><subject>Oxidative stress</subject><subject>Peroxidation</subject><subject>Polyphenols</subject><subject>Reactive oxygen species</subject><subject>Science & Technology</subject><subject>Tannic acid</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis 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Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice</title><author>Luduvico, Karina Pereira ; Spohr, Luiza ; Soares, Mayara Sandrielly Pereira ; Teixeira, Fernanda Cardoso ; de Farias, Alana Seixas ; Bona, Natália Pontes ; Pedra, Nathalia Stark ; de Oliveira Campello Felix, Anelize ; Spanevello, Roselia Maria ; Stefanello, Francieli Moro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-a91a74f3b435bb28b158937c6d1352ca3ab17a8cd06fdf619cab08e5f99adeab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Animal behavior</topic><topic>Animal cognition</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antidepressants</topic><topic>Antioxidants</topic><topic>Behavior</topic><topic>Biochemistry</topic><topic>Biochemistry & Molecular 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Tannic acid (TA) is a polyphenol with previously described antioxidant and neuroprotective properties. The aim of this study was to evaluate the effects of TA on lipopolysaccharide (LPS)-induced depressive-like behavior, as well as oxidative stress parameters and TNF-α levels in the brains of mice. Animals were pretreated once daily, with TA (30 or 60 mg/kg), fluoxetine (20 mg/kg) or vehicle for 7 days. On the 7th day, the animals received a single injection of LPS (830 μg/kg). After 24 h, open field, forced swimming, tail suspension, and splash tests were conducted. The endotoxin induced depressive-like behavior in these mice and this was attenuated by TA. In the cerebral cortex, hippocampus, and striatum, LPS increased lipid peroxidation and reactive oxygen species production, and this was also prevented by TA administration. TA treatment also prevented a decrease in catalase activity within the striatum. Further, LPS administration caused increased levels of TNF-α in all brain structures, and this was prevented in the cortex by TA treatment. In conclusion, TA shows many neuroprotective properties, with demonstrated antioxidant, anti-inflammatory and antidepressant effects in this animal model of acute depressive-like behavior. Therefore, this compound could provide an alternative therapeutic approach for the treatment of depression.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32500408</pmid><doi>10.1007/s11064-020-03064-5</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5945-3723</orcidid><orcidid>https://orcid.org/0000-0002-5117-2000</orcidid></addata></record> |
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| ispartof | Neurochemical research, 2020-09, Vol.45 (9), p.2032-2043 |
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| source | SpringerNature Journals; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Acids Animal behavior Animal cognition Animal models Animals Antidepressants Antioxidants Behavior Biochemistry Biochemistry & Molecular Biology Biomedical and Life Sciences Biomedicine Brain research Catalase Cell Biology Cerebral cortex Cytokines Drug therapy Endotoxins Fluoxetine Free radicals Inflammation Laboratory animals Life Sciences & Biomedicine Lipid peroxidation Lipids Lipopolysaccharides Mental depression Neostriatum Neurochemistry Neurology Neuroprotection Neurosciences Neurosciences & Neurology Original Paper Oxidative stress Peroxidation Polyphenols Reactive oxygen species Science & Technology Tannic acid Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Antidepressant Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice |
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