Significance of skull osteoporosis to the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma
Disruption of the tumor-brain barrier in meningioma plays a critical role in the development of peritumoral brain edema (PTBE). We hypothesized that osteoporotic conditions may be associated with PTBE occurrence after radiation in patients with intracranial meningioma. We measured Hounsfield units (...
Gespeichert in:
| Veröffentlicht in: | PloS one 2020-02, Vol.15 (2), p.e0226312 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 2 |
| container_start_page | e0226312 |
| container_title | PloS one |
| container_volume | 15 |
| creator | Lee, Ryang-Hun Kim, Jae Min Cheong, Jin Hwan Ryu, Je Il Kim, Young Soo Han, Myung-Hoon |
| description | Disruption of the tumor-brain barrier in meningioma plays a critical role in the development of peritumoral brain edema (PTBE). We hypothesized that osteoporotic conditions may be associated with PTBE occurrence after radiation in patients with intracranial meningioma.
We measured Hounsfield units (HU) of the frontal skull on simulation brain CT in patients who underwent linear accelerator (LINAC)-based radiation treatment for intracranial meningioma. Receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for several predictive factors. The cumulative hazard for PTBE was estimated and classified according to these factors. Hazard ratios were then estimated to identify independent predictive factors associated with the development of PTBE after radiation in intracranial meningioma patients.
A total of 83 intracranial meningiomas in 76 patients who received LINAC-based radiation treatment in our hospital over an approximate 5-year period were included for the study. We found mean frontal skull HU ≤630.625 and gross tumor volume >7.194 cc to be independent predictors of PTBE after radiation treatment in patients with meningioma (hazard ratio, 8.41; P = 0.019; hazard ratio, 5.92; P = 0.032, respectively). In addition, patients who were ≥65 years showed a marginally significant association with PTBE.
Our study suggests that possible osteoporotic conditions, large tumor volume, and older age may be associated with PTBE occurrence after LINAC-based radiation treatment for intracranial meningioma. In the future we anticipate that these findings may enhance the understanding of the underlying mechanisms of PTBE after radiation in meningioma patients. |
| doi_str_mv | 10.1371/journal.pone.0226312 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2357396694</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A614124859</galeid><doaj_id>oai_doaj_org_article_d0cc24cee54a4263b4a86a7e2dc2f72d</doaj_id><sourcerecordid>A614124859</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-a35c960bec77b799bbce899eb0fbfb3f8dc50ec19fd622a931b292c682d655223</originalsourceid><addsrcrecordid>eNqNk9-K1DAUxoso7rr6BqIBQfBixjRp0-ZGGAb_DAwuuOptOE1PZzK2TU3SVZ_GVzWz011mQEFykXDyO1-SL-ckydOUzlNepK93dnQ9tPPB9jinjAmesnvJeSo5mwlG-f2j9VnyyPsdpTkvhXiYnHFGheS0PE9-X5lNbxqjoddIbEP8t7FtifUB7WCd9caTYEnYIqnxGls7dNiHPTigM2HsrIOWVA5MT7DGDgg0AR1Zrz4ulrMKPNbEQW0gGNuT4BDCjUDEhxiLS09-mLCNgeBAO-hN1IuI6TfGdvA4edBA6_HJNF8kX969_bz8MFtfvl8tF-uZFpKFGfBcS0Er1EVRFVJWlcZSSqxoUzUVb8pa5xR1KptaMAaSpxWTTIuS1SLPGeMXyfOD7tBaryZvvWI8L7gUQmaRWB2I2sJODc504H4pC0bdBKzbKHDB6BZVTbVmmUbMM8jix1QZlAIKZLVmTcHqqPVmOm2sOqw17h_fnoie7vRmqzb2WhWUlaxMo8CLScDZ7yP68I8rT9QG4q1M39i9x53xWi1EmqUsK3MZqflfqDjidxodq6sxMX6S8OokITIBf4YNjN6r1dWn_2cvv56yL4_YLUIbtt624750_CmYHUAdC9Q7bO6cS6naN8etG2rfHGpqjpj27Nj1u6TbbuB_AMPRDrk</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2357396694</pqid></control><display><type>article</type><title>Significance of skull osteoporosis to the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Lee, Ryang-Hun ; Kim, Jae Min ; Cheong, Jin Hwan ; Ryu, Je Il ; Kim, Young Soo ; Han, Myung-Hoon</creator><creatorcontrib>Lee, Ryang-Hun ; Kim, Jae Min ; Cheong, Jin Hwan ; Ryu, Je Il ; Kim, Young Soo ; Han, Myung-Hoon</creatorcontrib><description>Disruption of the tumor-brain barrier in meningioma plays a critical role in the development of peritumoral brain edema (PTBE). We hypothesized that osteoporotic conditions may be associated with PTBE occurrence after radiation in patients with intracranial meningioma.
We measured Hounsfield units (HU) of the frontal skull on simulation brain CT in patients who underwent linear accelerator (LINAC)-based radiation treatment for intracranial meningioma. Receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for several predictive factors. The cumulative hazard for PTBE was estimated and classified according to these factors. Hazard ratios were then estimated to identify independent predictive factors associated with the development of PTBE after radiation in intracranial meningioma patients.
A total of 83 intracranial meningiomas in 76 patients who received LINAC-based radiation treatment in our hospital over an approximate 5-year period were included for the study. We found mean frontal skull HU ≤630.625 and gross tumor volume >7.194 cc to be independent predictors of PTBE after radiation treatment in patients with meningioma (hazard ratio, 8.41; P = 0.019; hazard ratio, 5.92; P = 0.032, respectively). In addition, patients who were ≥65 years showed a marginally significant association with PTBE.
Our study suggests that possible osteoporotic conditions, large tumor volume, and older age may be associated with PTBE occurrence after LINAC-based radiation treatment for intracranial meningioma. In the future we anticipate that these findings may enhance the understanding of the underlying mechanisms of PTBE after radiation in meningioma patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0226312</identifier><identifier>PMID: 32069308</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age Factors ; Aged ; Biology and Life Sciences ; Biomedical materials ; Brain ; Brain cancer ; Brain Edema - etiology ; Brain tumors ; Care and treatment ; CAT scans ; Cerebral edema ; Communications systems ; Disruption ; Edema ; Female ; Follow-Up Studies ; Histology ; Humans ; Linear accelerators ; Magnetic resonance imaging ; Male ; Measurement methods ; Medical imaging ; Medicine and Health Sciences ; Meningeal Neoplasms - radiotherapy ; Meningioma ; Meningioma - radiotherapy ; Middle Aged ; Neurosurgery ; Osteoporosis ; Osteoporosis - complications ; Patients ; Radiation ; Radiation (Physics) ; Radiation therapy ; Radiosurgery - adverse effects ; Radiotherapy ; Research and Analysis Methods ; Retrospective Studies ; Risk Factors ; Simulation ; Skull ; Skull - pathology ; Surgery ; Tumor Burden ; Tumors</subject><ispartof>PloS one, 2020-02, Vol.15 (2), p.e0226312</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Lee et al 2020 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a35c960bec77b799bbce899eb0fbfb3f8dc50ec19fd622a931b292c682d655223</citedby><cites>FETCH-LOGICAL-c692t-a35c960bec77b799bbce899eb0fbfb3f8dc50ec19fd622a931b292c682d655223</cites><orcidid>0000-0003-1728-5017</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028281/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028281/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32069308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Ryang-Hun</creatorcontrib><creatorcontrib>Kim, Jae Min</creatorcontrib><creatorcontrib>Cheong, Jin Hwan</creatorcontrib><creatorcontrib>Ryu, Je Il</creatorcontrib><creatorcontrib>Kim, Young Soo</creatorcontrib><creatorcontrib>Han, Myung-Hoon</creatorcontrib><title>Significance of skull osteoporosis to the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Disruption of the tumor-brain barrier in meningioma plays a critical role in the development of peritumoral brain edema (PTBE). We hypothesized that osteoporotic conditions may be associated with PTBE occurrence after radiation in patients with intracranial meningioma.
We measured Hounsfield units (HU) of the frontal skull on simulation brain CT in patients who underwent linear accelerator (LINAC)-based radiation treatment for intracranial meningioma. Receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for several predictive factors. The cumulative hazard for PTBE was estimated and classified according to these factors. Hazard ratios were then estimated to identify independent predictive factors associated with the development of PTBE after radiation in intracranial meningioma patients.
A total of 83 intracranial meningiomas in 76 patients who received LINAC-based radiation treatment in our hospital over an approximate 5-year period were included for the study. We found mean frontal skull HU ≤630.625 and gross tumor volume >7.194 cc to be independent predictors of PTBE after radiation treatment in patients with meningioma (hazard ratio, 8.41; P = 0.019; hazard ratio, 5.92; P = 0.032, respectively). In addition, patients who were ≥65 years showed a marginally significant association with PTBE.
Our study suggests that possible osteoporotic conditions, large tumor volume, and older age may be associated with PTBE occurrence after LINAC-based radiation treatment for intracranial meningioma. In the future we anticipate that these findings may enhance the understanding of the underlying mechanisms of PTBE after radiation in meningioma patients.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Biology and Life Sciences</subject><subject>Biomedical materials</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Brain Edema - etiology</subject><subject>Brain tumors</subject><subject>Care and treatment</subject><subject>CAT scans</subject><subject>Cerebral edema</subject><subject>Communications systems</subject><subject>Disruption</subject><subject>Edema</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Histology</subject><subject>Humans</subject><subject>Linear accelerators</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Measurement methods</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Meningeal Neoplasms - radiotherapy</subject><subject>Meningioma</subject><subject>Meningioma - radiotherapy</subject><subject>Middle Aged</subject><subject>Neurosurgery</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Patients</subject><subject>Radiation</subject><subject>Radiation (Physics)</subject><subject>Radiation therapy</subject><subject>Radiosurgery - adverse effects</subject><subject>Radiotherapy</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Simulation</subject><subject>Skull</subject><subject>Skull - pathology</subject><subject>Surgery</subject><subject>Tumor Burden</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-K1DAUxoso7rr6BqIBQfBixjRp0-ZGGAb_DAwuuOptOE1PZzK2TU3SVZ_GVzWz011mQEFykXDyO1-SL-ckydOUzlNepK93dnQ9tPPB9jinjAmesnvJeSo5mwlG-f2j9VnyyPsdpTkvhXiYnHFGheS0PE9-X5lNbxqjoddIbEP8t7FtifUB7WCd9caTYEnYIqnxGls7dNiHPTigM2HsrIOWVA5MT7DGDgg0AR1Zrz4ulrMKPNbEQW0gGNuT4BDCjUDEhxiLS09-mLCNgeBAO-hN1IuI6TfGdvA4edBA6_HJNF8kX969_bz8MFtfvl8tF-uZFpKFGfBcS0Er1EVRFVJWlcZSSqxoUzUVb8pa5xR1KptaMAaSpxWTTIuS1SLPGeMXyfOD7tBaryZvvWI8L7gUQmaRWB2I2sJODc504H4pC0bdBKzbKHDB6BZVTbVmmUbMM8jix1QZlAIKZLVmTcHqqPVmOm2sOqw17h_fnoie7vRmqzb2WhWUlaxMo8CLScDZ7yP68I8rT9QG4q1M39i9x53xWi1EmqUsK3MZqflfqDjidxodq6sxMX6S8OokITIBf4YNjN6r1dWn_2cvv56yL4_YLUIbtt624750_CmYHUAdC9Q7bO6cS6naN8etG2rfHGpqjpj27Nj1u6TbbuB_AMPRDrk</recordid><startdate>20200218</startdate><enddate>20200218</enddate><creator>Lee, Ryang-Hun</creator><creator>Kim, Jae Min</creator><creator>Cheong, Jin Hwan</creator><creator>Ryu, Je Il</creator><creator>Kim, Young Soo</creator><creator>Han, Myung-Hoon</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1728-5017</orcidid></search><sort><creationdate>20200218</creationdate><title>Significance of skull osteoporosis to the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma</title><author>Lee, Ryang-Hun ; Kim, Jae Min ; Cheong, Jin Hwan ; Ryu, Je Il ; Kim, Young Soo ; Han, Myung-Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a35c960bec77b799bbce899eb0fbfb3f8dc50ec19fd622a931b292c682d655223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Biology and Life Sciences</topic><topic>Biomedical materials</topic><topic>Brain</topic><topic>Brain cancer</topic><topic>Brain Edema - etiology</topic><topic>Brain tumors</topic><topic>Care and treatment</topic><topic>CAT scans</topic><topic>Cerebral edema</topic><topic>Communications systems</topic><topic>Disruption</topic><topic>Edema</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Histology</topic><topic>Humans</topic><topic>Linear accelerators</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Measurement methods</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Meningeal Neoplasms - radiotherapy</topic><topic>Meningioma</topic><topic>Meningioma - radiotherapy</topic><topic>Middle Aged</topic><topic>Neurosurgery</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Patients</topic><topic>Radiation</topic><topic>Radiation (Physics)</topic><topic>Radiation therapy</topic><topic>Radiosurgery - adverse effects</topic><topic>Radiotherapy</topic><topic>Research and Analysis Methods</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Simulation</topic><topic>Skull</topic><topic>Skull - pathology</topic><topic>Surgery</topic><topic>Tumor Burden</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Ryang-Hun</creatorcontrib><creatorcontrib>Kim, Jae Min</creatorcontrib><creatorcontrib>Cheong, Jin Hwan</creatorcontrib><creatorcontrib>Ryu, Je Il</creatorcontrib><creatorcontrib>Kim, Young Soo</creatorcontrib><creatorcontrib>Han, Myung-Hoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Ryang-Hun</au><au>Kim, Jae Min</au><au>Cheong, Jin Hwan</au><au>Ryu, Je Il</au><au>Kim, Young Soo</au><au>Han, Myung-Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of skull osteoporosis to the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-02-18</date><risdate>2020</risdate><volume>15</volume><issue>2</issue><spage>e0226312</spage><pages>e0226312-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Disruption of the tumor-brain barrier in meningioma plays a critical role in the development of peritumoral brain edema (PTBE). We hypothesized that osteoporotic conditions may be associated with PTBE occurrence after radiation in patients with intracranial meningioma.
We measured Hounsfield units (HU) of the frontal skull on simulation brain CT in patients who underwent linear accelerator (LINAC)-based radiation treatment for intracranial meningioma. Receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for several predictive factors. The cumulative hazard for PTBE was estimated and classified according to these factors. Hazard ratios were then estimated to identify independent predictive factors associated with the development of PTBE after radiation in intracranial meningioma patients.
A total of 83 intracranial meningiomas in 76 patients who received LINAC-based radiation treatment in our hospital over an approximate 5-year period were included for the study. We found mean frontal skull HU ≤630.625 and gross tumor volume >7.194 cc to be independent predictors of PTBE after radiation treatment in patients with meningioma (hazard ratio, 8.41; P = 0.019; hazard ratio, 5.92; P = 0.032, respectively). In addition, patients who were ≥65 years showed a marginally significant association with PTBE.
Our study suggests that possible osteoporotic conditions, large tumor volume, and older age may be associated with PTBE occurrence after LINAC-based radiation treatment for intracranial meningioma. In the future we anticipate that these findings may enhance the understanding of the underlying mechanisms of PTBE after radiation in meningioma patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32069308</pmid><doi>10.1371/journal.pone.0226312</doi><tpages>e0226312</tpages><orcidid>https://orcid.org/0000-0003-1728-5017</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-02, Vol.15 (2), p.e0226312 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2357396694 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Factors Aged Biology and Life Sciences Biomedical materials Brain Brain cancer Brain Edema - etiology Brain tumors Care and treatment CAT scans Cerebral edema Communications systems Disruption Edema Female Follow-Up Studies Histology Humans Linear accelerators Magnetic resonance imaging Male Measurement methods Medical imaging Medicine and Health Sciences Meningeal Neoplasms - radiotherapy Meningioma Meningioma - radiotherapy Middle Aged Neurosurgery Osteoporosis Osteoporosis - complications Patients Radiation Radiation (Physics) Radiation therapy Radiosurgery - adverse effects Radiotherapy Research and Analysis Methods Retrospective Studies Risk Factors Simulation Skull Skull - pathology Surgery Tumor Burden Tumors |
| title | Significance of skull osteoporosis to the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T12%3A57%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Significance%20of%20skull%20osteoporosis%20to%20the%20development%20of%20peritumoral%20brain%20edema%20after%20LINAC-based%20radiation%20treatment%20in%20patients%20with%20intracranial%20meningioma&rft.jtitle=PloS%20one&rft.au=Lee,%20Ryang-Hun&rft.date=2020-02-18&rft.volume=15&rft.issue=2&rft.spage=e0226312&rft.pages=e0226312-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0226312&rft_dat=%3Cgale_plos_%3EA614124859%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2357396694&rft_id=info:pmid/32069308&rft_galeid=A614124859&rft_doaj_id=oai_doaj_org_article_d0cc24cee54a4263b4a86a7e2dc2f72d&rfr_iscdi=true |