Cholesterol-functionalized carvedilol-loaded PLGA nanoparticles: anti-inflammatory, antioxidant, and antitumor effects
The inflammation has been identified as factor of tumor progression, which has increased the interest and use of molecules with anti-inflammatory and antioxidant activities in the cancer treatment. In this study, the antioxidant, anti-inflammatory, and antitumor potentials of carvedilol was explored...
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| Veröffentlicht in: | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2020-05, Vol.22 (5), Article 115 |
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| creator | de S. L. Oliveira, Ana Luiza C. dos Santos-Silva, Alaine M. da Silva-Júnior, Arnóbio A. Garcia, Vinícius B. de Araújo, Aurigena A. de Geus-Oei, Lioe-Fee Chan, Alan B. Cruz, Luis J. de Araújo Júnior, Raimundo F. |
| description | The inflammation has been identified as factor of tumor progression, which has increased the interest and use of molecules with anti-inflammatory and antioxidant activities in the cancer treatment. In this study, the antioxidant, anti-inflammatory, and antitumor potentials of carvedilol was explored in a different approach. The cholesterol (CHO) was investigated as facilitated agent in the action of carvedilol-loaded nanoparticles. Different formulations exhibited spherical and stable nanoparticle with mean diameter size |
| doi_str_mv | 10.1007/s11051-020-04832-8 |
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Graphical abstract</description><subject>Anticancer properties</subject><subject>Antioxidants</subject><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cell viability</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry, Multidisciplinary</subject><subject>Cholesterol</subject><subject>Colorectal carcinoma</subject><subject>Copolymers</subject><subject>Flow cytometry</subject><subject>Glutathione</subject><subject>Inflammation</subject><subject>Inorganic Chemistry</subject><subject>Lasers</subject><subject>Leukocyte migration</subject><subject>Leukocytes</subject><subject>Materials Science</subject><subject>Materials Science, Multidisciplinary</subject><subject>Nanoparticles</subject><subject>Nanoscience & Nanotechnology</subject><subject>Nanotechnology</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Oxidative stress</subject><subject>Peritonitis</subject><subject>Photonics</subject><subject>Physical Chemistry</subject><subject>Physical Sciences</subject><subject>Polylactide-co-glycolide</subject><subject>Research Paper</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Technology</subject><issn>1388-0764</issn><issn>1572-896X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNUMFu1DAUjBBIlMIPcFqJI7g827GTcKui0lZaiR5A4mbZsQ2usvZiO4Xy9X27QXBDPb3xeObpzTTNawpnFKB7XygFQQkwIND2nJH-SXNCRYdgkF-fIuZ9T6CT7fPmRSm3AFSygZ00d-P3NLtSXU4z8UucakhRz-G3s5tJ5ztnw4w_c9IWmZvt5fkm6pj2OtcwofHDRscaSIh-1rudrinfvztS6VewOA8PeyTqskt547x3Uy0vm2dez8W9-jNPmy8fLz6PV2T76fJ6PN-SiUteiRG-7ajgwjJtDACYwUgrheyENxSk6Y01PWXOgOROM6Gp0IZ7BnawvPP8tHmz7t3n9GPBnOo2LRkDFsVaLEEAtAOq2KqaciolO6_2Oex0vlcU1KFftfarsF917Ff1aOpX009nki9TcHFyf414q-Ccy3ZABGwMVR-aHdMSK1rfPt6Kar6qCyriN5f_ZfjPeQ-v_aDn</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>de S. 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Oliveira, Ana Luiza C.</au><au>dos Santos-Silva, Alaine M.</au><au>da Silva-Júnior, Arnóbio A.</au><au>Garcia, Vinícius B.</au><au>de Araújo, Aurigena A.</au><au>de Geus-Oei, Lioe-Fee</au><au>Chan, Alan B.</au><au>Cruz, Luis J.</au><au>de Araújo Júnior, Raimundo F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholesterol-functionalized carvedilol-loaded PLGA nanoparticles: anti-inflammatory, antioxidant, and antitumor effects</atitle><jtitle>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</jtitle><stitle>J Nanopart Res</stitle><stitle>J NANOPART RES</stitle><date>2020-05-01</date><risdate>2020</risdate><volume>22</volume><issue>5</issue><artnum>115</artnum><issn>1388-0764</issn><eissn>1572-896X</eissn><abstract>The inflammation has been identified as factor of tumor progression, which has increased the interest and use of molecules with anti-inflammatory and antioxidant activities in the cancer treatment. In this study, the antioxidant, anti-inflammatory, and antitumor potentials of carvedilol was explored in a different approach. The cholesterol (CHO) was investigated as facilitated agent in the action of carvedilol-loaded nanoparticles. Different formulations exhibited spherical and stable nanoparticle with mean diameter size < 250 nm. The cholesterol changed the copolymer-drug interactions and the encapsulation efficiency. The in vitro cancer study was performed using murine colorectal cancer cell line (CT-26) to observe the cell viability and apoptosis on MTS assay and flow cytometry, respectively. The experiments have demonstrated that cholesterol improved the performance of drug-loaded nanoparticles, which was much better than free drug. The in vivo inflammation peritonitis model revealed that carvedilol-loaded nanoparticles increased the level of glutathione and leukocyte migration mainly when the functionalized drug-loaded nanoparticles were tested, in a lower dose than the free drug. As hypothesized, the experimental data suggest that cholesterol-functionalized carvedilol-loaded PLGA nanoparticles can be a novel and promising approach in the inflammation-induced cancer therapy since showed anti-inflammatory, antioxidant, and antitumor effects.
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| subjects | Anticancer properties Antioxidants Antitumor activity Apoptosis Cancer Cell viability Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chemistry, Multidisciplinary Cholesterol Colorectal carcinoma Copolymers Flow cytometry Glutathione Inflammation Inorganic Chemistry Lasers Leukocyte migration Leukocytes Materials Science Materials Science, Multidisciplinary Nanoparticles Nanoscience & Nanotechnology Nanotechnology Optical Devices Optics Oxidative stress Peritonitis Photonics Physical Chemistry Physical Sciences Polylactide-co-glycolide Research Paper Science & Technology Science & Technology - Other Topics Technology |
| title | Cholesterol-functionalized carvedilol-loaded PLGA nanoparticles: anti-inflammatory, antioxidant, and antitumor effects |
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