Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities
Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, vir...
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| Veröffentlicht in: | Applied sciences 2020-04, Vol.10 (8), p.2668 |
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| creator | Batiha, Gaber El-Saber Magdy Beshbishy, Amany Wasef, Lamiaa Elewa, Yaser H. A. Abd El-Hack, Mohamed E. Taha, Ayman E. Al-Sagheer, Adham Abdullah Devkota, Hari Prasad Tufarelli, Vincenzo |
| description | Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, viral infections, and wounds and found to be effective as an immune system rejuvenator, antioxidant, antimicrobial, and anti-inflammatory agent. U. tomentosa is rich in many phytoconstituents such as oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes. Biological activities of U. tomentosa have been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia and Theileria parasites. Several formulations of cat’s claw (e.g., tinctures, decoctions, capsules, extracts, and teas) are recently available in the market. The current review covers the chemical constituents, biological activities, pharmacokinetics, and toxic properties of U. tomentosa extracts. |
| doi_str_mv | 10.3390/app10082668 |
| format | Article |
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DC.: A Review on Chemical Constituents and Biological Activities</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Batiha, Gaber El-Saber ; Magdy Beshbishy, Amany ; Wasef, Lamiaa ; Elewa, Yaser H. A. ; Abd El-Hack, Mohamed E. ; Taha, Ayman E. ; Al-Sagheer, Adham Abdullah ; Devkota, Hari Prasad ; Tufarelli, Vincenzo</creator><creatorcontrib>Batiha, Gaber El-Saber ; Magdy Beshbishy, Amany ; Wasef, Lamiaa ; Elewa, Yaser H. A. ; Abd El-Hack, Mohamed E. ; Taha, Ayman E. ; Al-Sagheer, Adham Abdullah ; Devkota, Hari Prasad ; Tufarelli, Vincenzo</creatorcontrib><description>Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, viral infections, and wounds and found to be effective as an immune system rejuvenator, antioxidant, antimicrobial, and anti-inflammatory agent. U. tomentosa is rich in many phytoconstituents such as oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes. Biological activities of U. tomentosa have been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia and Theileria parasites. Several formulations of cat’s claw (e.g., tinctures, decoctions, capsules, extracts, and teas) are recently available in the market. The current review covers the chemical constituents, biological activities, pharmacokinetics, and toxic properties of U. tomentosa extracts.</description><identifier>ISSN: 2076-3417</identifier><identifier>EISSN: 2076-3417</identifier><identifier>DOI: 10.3390/app10082668</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Abscesses ; Acids ; Alkaloids ; Anti-inflammatory agents ; Antioxidants ; Apoptosis ; Arthritis ; Asthma ; biological activities ; Breast cancer ; cat’s claw ; Constituents ; Drug dosages ; Fever ; Gene expression ; Glycosides ; Immune system ; Indoles ; Infections ; Inflammation ; Microorganisms ; Nonsteroidal anti-inflammatory drugs ; Organic acids ; Oxidative stress ; Parasites ; Pharmacokinetics ; phytoconstituents ; Proanthocyanidins ; Rainforests ; Sterols ; Studies ; Triterpenes ; Uncaria tomentosa ; Urinary tract ; Urinary tract diseases ; Urinary tract infections ; Urogenital system ; Viruses</subject><ispartof>Applied sciences, 2020-04, Vol.10 (8), p.2668</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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U. tomentosa is rich in many phytoconstituents such as oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes. Biological activities of U. tomentosa have been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia and Theileria parasites. Several formulations of cat’s claw (e.g., tinctures, decoctions, capsules, extracts, and teas) are recently available in the market. 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A.</au><au>Abd El-Hack, Mohamed E.</au><au>Taha, Ayman E.</au><au>Al-Sagheer, Adham Abdullah</au><au>Devkota, Hari Prasad</au><au>Tufarelli, Vincenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities</atitle><jtitle>Applied sciences</jtitle><date>2020-04-01</date><risdate>2020</risdate><volume>10</volume><issue>8</issue><spage>2668</spage><pages>2668-</pages><issn>2076-3417</issn><eissn>2076-3417</eissn><abstract>Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, viral infections, and wounds and found to be effective as an immune system rejuvenator, antioxidant, antimicrobial, and anti-inflammatory agent. U. tomentosa is rich in many phytoconstituents such as oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes. Biological activities of U. tomentosa have been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia and Theileria parasites. Several formulations of cat’s claw (e.g., tinctures, decoctions, capsules, extracts, and teas) are recently available in the market. 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| subjects | Abscesses Acids Alkaloids Anti-inflammatory agents Antioxidants Apoptosis Arthritis Asthma biological activities Breast cancer cat’s claw Constituents Drug dosages Fever Gene expression Glycosides Immune system Indoles Infections Inflammation Microorganisms Nonsteroidal anti-inflammatory drugs Organic acids Oxidative stress Parasites Pharmacokinetics phytoconstituents Proanthocyanidins Rainforests Sterols Studies Triterpenes Uncaria tomentosa Urinary tract Urinary tract diseases Urinary tract infections Urogenital system Viruses |
| title | Uncaria tomentosa (Willd. ex Schult.) DC.: A Review on Chemical Constituents and Biological Activities |
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