Risk of insulin resistance with statin therapy in individuals without dyslipidemia: A propensity‐matched analysis in a registry population

Several studies suggest the higher vulnerability of individuals with lower low‐density lipoprotein cholesterol (LDL‐C) levels to diabetes mellitus. However, the discordance between high and low baseline LDL‐C levels shown by statin‐induced insulin resistance is not fully understood. This study aimed to explore the relationship between baseline LDL‐C levels and the risk of statin‐induced insulin resistance during statin therapy. In total, 2660 (451 with dyslipidemia and 2209 without dyslipidemia) consecutive patients were enrolled. Their baseline clinical data were adjusted using a propensity score matching analysis, using the logistic regression model. Insulin resistance index was based on the homeostatic model assessment‐insulin resistance (HOMA‐IR) and was monitored for a median of 2 years. Among the individuals who received statin therapy, those with and without dyslipidemia showed significantly decreased LDL‐C levels (all P