Antiphospholipid antibody‐activated NETs exacerbate trophoblast and endothelial cell injury in obstetric antiphospholipid syndrome

Despite the widespread use of antiplatelets and anticoagulants, women with antiphospholipid syndrome (APS) may face pregnancy complications associated with placental dysplasia. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of many autoimmune diseases, including vascular APS;...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-06, Vol.24 (12), p.6690-6703
Hauptverfasser:	Lu, Yuan, Dong, Yan, Zhang, Yan, Shen, Di, Wang, Xiyao, Ge, Ruxiu, Zhang, Meihua, Xia, Yu, Wang, Xietong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AKT protein Antibodies Antibodies, Antiphospholipid - adverse effects Anticoagulants Antiphospholipid antibodies Antiphospholipid syndrome Antiphospholipid Syndrome - blood Antiphospholipid Syndrome - immunology Antiphospholipid Syndrome - pathology Apoptosis Autoimmune diseases Cell Biology Cell injury Cell Movement - drug effects Cell-Free Nucleic Acids - metabolism Deoxyribonucleic acid DNA Dysplasia Eclampsia endothelial cell Endothelial cells Enzyme Inhibitors - pharmacology Extracellular Traps - metabolism Female Glycoproteins Hospitals Human Umbilical Vein Endothelial Cells - pathology Humans Immunoglobulin G Immunoglobulin G - blood Leukocyte migration Leukocytes (neutrophilic) Life Sciences & Biomedicine Lupus MAP kinase Medicine, Research & Experimental Neovascularization, Physiologic - drug effects neutrophil extracellular trap Neutrophils obstetric APS Obstetrics Original Pathogenesis Patients Placenta Placental dysplasia Pregnancy Pregnancy complications Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Research & Experimental Medicine Science & Technology Signal transduction Signal Transduction - drug effects Therapeutic applications Thrombosis trophoblast Trophoblasts Trophoblasts - pathology Umbilical vein Womens health Young Adult
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