pH-Responsive hyperbranched polypeptides based on Schiff bases as drug carriers for reducing toxicity of chemotherapy
Polymeric micelles have great potential in drug delivery systems because of their multifunctional adjustability, excellent stability, and biocompatibility. To further increase the drug loading efficiency and controlled release ability, a pH-responsive hyperbranched copolymer methoxy poly(ethylene gl...
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| creator | Yan, Rui Liu, Xinyi Xiong, Junjie Feng, Qiyi Xu, Junhuai Wang, Haibo Xiao, Kai |
| description | Polymeric micelles have great potential in drug delivery systems because of their multifunctional adjustability, excellent stability, and biocompatibility. To further increase the drug loading efficiency and controlled release ability, a pH-responsive hyperbranched copolymer methoxy poly(ethylene glycol)-
b
-polyethyleneimine-poly(
N
-Cbz-
l
-lysine) (MPEG-PEI-PBLL) was synthesized successfully. MPEG-PEI-NH
2
was synthesized to initiate the ring-opening polymerization of benzyloxycarbonyl substituted lysine
N
-carboxyanhydride (
Z
-lys NCA). The introduction of Schiff bases in the polymer make it possible to respond to the variation of pH values, which cleaved at pH 5.0 while stable at pH 7.4. As the polymer was amphiphilic, MPEG-PEI-PBLL could self-assemble into micelles. Owing to the introduction of PEI, which make the copolymer hyperbranched, the pH-responsive micelles could efficiently encapsulate theranostic agents, such as doxorubicin (DOX) for chemotherapy and NIRF dye DiD for
in vivo
near-infrared (NIR) imaging. The drug delivery system prolonged the drug circulation time in blood and allowed the drug accumulate effectively at the tumor site. Following the guidance, the DOX was applied in chemotherapy to achieve cancer therapeutic efficiency. All the results demonstrate that the polymer micelles have great potential for cancer theranostics.
Polymeric micelles have great potential in drug delivery systems because of their multifunctional adjustability, excellent stability, and biocompatibility. |
| doi_str_mv | 10.1039/d0ra01241f |
| format | Article |
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b
-polyethyleneimine-poly(
N
-Cbz-
l
-lysine) (MPEG-PEI-PBLL) was synthesized successfully. MPEG-PEI-NH
2
was synthesized to initiate the ring-opening polymerization of benzyloxycarbonyl substituted lysine
N
-carboxyanhydride (
Z
-lys NCA). The introduction of Schiff bases in the polymer make it possible to respond to the variation of pH values, which cleaved at pH 5.0 while stable at pH 7.4. As the polymer was amphiphilic, MPEG-PEI-PBLL could self-assemble into micelles. Owing to the introduction of PEI, which make the copolymer hyperbranched, the pH-responsive micelles could efficiently encapsulate theranostic agents, such as doxorubicin (DOX) for chemotherapy and NIRF dye DiD for
in vivo
near-infrared (NIR) imaging. The drug delivery system prolonged the drug circulation time in blood and allowed the drug accumulate effectively at the tumor site. Following the guidance, the DOX was applied in chemotherapy to achieve cancer therapeutic efficiency. All the results demonstrate that the polymer micelles have great potential for cancer theranostics.
Polymeric micelles have great potential in drug delivery systems because of their multifunctional adjustability, excellent stability, and biocompatibility.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d0ra01241f</identifier><identifier>PMID: 35492972</identifier><language>eng</language><publisher>CAMBRIDGE: Royal Soc Chemistry</publisher><subject>Biocompatibility ; Blood circulation ; Cancer ; Chemistry ; Chemistry, Multidisciplinary ; Chemotherapy ; Control stability ; Controlled release ; Copolymers ; Doxorubicin ; Drug carriers ; Drug delivery systems ; Imines ; Infrared imaging ; Lysine ; Micelles ; MPEG encoders ; Physical Sciences ; Polyethylene glycol ; Polyethyleneimine ; Polymers ; Polypeptides ; Ring opening polymerization ; Science & Technology ; Toxicity</subject><ispartof>RSC advances, 2020-04, Vol.1 (23), p.13889-13899</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2020</rights><rights>This journal is © The Royal Society of Chemistry 2020 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>14</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000530352000062</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c495t-28ed9e8f3f7943d0af507939d0ad65f0e80a5d65cfbcc1ee26b7f05c90f3c3373</citedby><cites>FETCH-LOGICAL-c495t-28ed9e8f3f7943d0af507939d0ad65f0e80a5d65cfbcc1ee26b7f05c90f3c3373</cites><orcidid>0000-0001-5321-8888 ; 0000-0001-5597-6762</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051653/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051653/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2115,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35492972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Rui</creatorcontrib><creatorcontrib>Liu, Xinyi</creatorcontrib><creatorcontrib>Xiong, Junjie</creatorcontrib><creatorcontrib>Feng, Qiyi</creatorcontrib><creatorcontrib>Xu, Junhuai</creatorcontrib><creatorcontrib>Wang, Haibo</creatorcontrib><creatorcontrib>Xiao, Kai</creatorcontrib><title>pH-Responsive hyperbranched polypeptides based on Schiff bases as drug carriers for reducing toxicity of chemotherapy</title><title>RSC advances</title><addtitle>RSC ADV</addtitle><addtitle>RSC Adv</addtitle><description>Polymeric micelles have great potential in drug delivery systems because of their multifunctional adjustability, excellent stability, and biocompatibility. To further increase the drug loading efficiency and controlled release ability, a pH-responsive hyperbranched copolymer methoxy poly(ethylene glycol)-
b
-polyethyleneimine-poly(
N
-Cbz-
l
-lysine) (MPEG-PEI-PBLL) was synthesized successfully. MPEG-PEI-NH
2
was synthesized to initiate the ring-opening polymerization of benzyloxycarbonyl substituted lysine
N
-carboxyanhydride (
Z
-lys NCA). The introduction of Schiff bases in the polymer make it possible to respond to the variation of pH values, which cleaved at pH 5.0 while stable at pH 7.4. As the polymer was amphiphilic, MPEG-PEI-PBLL could self-assemble into micelles. Owing to the introduction of PEI, which make the copolymer hyperbranched, the pH-responsive micelles could efficiently encapsulate theranostic agents, such as doxorubicin (DOX) for chemotherapy and NIRF dye DiD for
in vivo
near-infrared (NIR) imaging. The drug delivery system prolonged the drug circulation time in blood and allowed the drug accumulate effectively at the tumor site. Following the guidance, the DOX was applied in chemotherapy to achieve cancer therapeutic efficiency. All the results demonstrate that the polymer micelles have great potential for cancer theranostics.
Polymeric micelles have great potential in drug delivery systems because of their multifunctional adjustability, excellent stability, and biocompatibility.</description><subject>Biocompatibility</subject><subject>Blood circulation</subject><subject>Cancer</subject><subject>Chemistry</subject><subject>Chemistry, Multidisciplinary</subject><subject>Chemotherapy</subject><subject>Control stability</subject><subject>Controlled release</subject><subject>Copolymers</subject><subject>Doxorubicin</subject><subject>Drug carriers</subject><subject>Drug delivery systems</subject><subject>Imines</subject><subject>Infrared imaging</subject><subject>Lysine</subject><subject>Micelles</subject><subject>MPEG encoders</subject><subject>Physical Sciences</subject><subject>Polyethylene glycol</subject><subject>Polyethyleneimine</subject><subject>Polymers</subject><subject>Polypeptides</subject><subject>Ring opening polymerization</subject><subject>Science & Technology</subject><subject>Toxicity</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqNksFvFCEUxidGY5vai3cNxkujGWVgYIeLSbNaa9LEpOqZMPDYoZmFKTDV_e-Lu3WtHoxceI_3e18efFTV0wa_aTAVbw2OCjekbeyD6pDgltcEc_HwXnxQHad0hcvirCG8eVwdUNYKIhbksJqn8_oS0hR8cjeAhs0EsY_K6wEMmsJY8ik7Awn1KpWj4NEXPThrt3lCKiET5xXSKkYHMSEbIopgZu38CuXww2mXNyhYVBTXIQ8Q1bR5Uj2yakxwfLcfVd_OPnxdntcXnz9-Wp5e1LoVLNekAyOgs9QuREsNVpbhhaCiRIYzi6HDipVI217rBoDwfmEx0wJbqild0KPq3U53mvs1GA0-RzXKKbq1ihsZlJN_Vrwb5CrcSIFZwxktAid3AjFcz5CyXLukYRyVhzAnSTjrOCtPSwr68i_0KszRl-tJQjvBOkoEL9SrHaVjSCmC3Q_TYPnTUPkeX55uDT0r8PP74-_RX_YVoNsB36EPNmkHXsMeK2MxiikjW-_J0mWVXfDLMPtcWl__f2uhn-3omPQe-v31Sv3Fv-pyMpbeAnm20-8</recordid><startdate>20200406</startdate><enddate>20200406</enddate><creator>Yan, Rui</creator><creator>Liu, Xinyi</creator><creator>Xiong, Junjie</creator><creator>Feng, Qiyi</creator><creator>Xu, Junhuai</creator><creator>Wang, Haibo</creator><creator>Xiao, Kai</creator><general>Royal Soc Chemistry</general><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5321-8888</orcidid><orcidid>https://orcid.org/0000-0001-5597-6762</orcidid></search><sort><creationdate>20200406</creationdate><title>pH-Responsive hyperbranched polypeptides based on Schiff bases as drug carriers for reducing toxicity of chemotherapy</title><author>Yan, Rui ; Liu, Xinyi ; Xiong, Junjie ; Feng, Qiyi ; Xu, Junhuai ; Wang, Haibo ; Xiao, Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-28ed9e8f3f7943d0af507939d0ad65f0e80a5d65cfbcc1ee26b7f05c90f3c3373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biocompatibility</topic><topic>Blood circulation</topic><topic>Cancer</topic><topic>Chemistry</topic><topic>Chemistry, Multidisciplinary</topic><topic>Chemotherapy</topic><topic>Control stability</topic><topic>Controlled release</topic><topic>Copolymers</topic><topic>Doxorubicin</topic><topic>Drug carriers</topic><topic>Drug delivery systems</topic><topic>Imines</topic><topic>Infrared imaging</topic><topic>Lysine</topic><topic>Micelles</topic><topic>MPEG encoders</topic><topic>Physical Sciences</topic><topic>Polyethylene glycol</topic><topic>Polyethyleneimine</topic><topic>Polymers</topic><topic>Polypeptides</topic><topic>Ring opening polymerization</topic><topic>Science & Technology</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Rui</creatorcontrib><creatorcontrib>Liu, Xinyi</creatorcontrib><creatorcontrib>Xiong, Junjie</creatorcontrib><creatorcontrib>Feng, Qiyi</creatorcontrib><creatorcontrib>Xu, Junhuai</creatorcontrib><creatorcontrib>Wang, Haibo</creatorcontrib><creatorcontrib>Xiao, Kai</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Rui</au><au>Liu, Xinyi</au><au>Xiong, Junjie</au><au>Feng, Qiyi</au><au>Xu, Junhuai</au><au>Wang, Haibo</au><au>Xiao, Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>pH-Responsive hyperbranched polypeptides based on Schiff bases as drug carriers for reducing toxicity of chemotherapy</atitle><jtitle>RSC advances</jtitle><stitle>RSC ADV</stitle><addtitle>RSC Adv</addtitle><date>2020-04-06</date><risdate>2020</risdate><volume>1</volume><issue>23</issue><spage>13889</spage><epage>13899</epage><pages>13889-13899</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Polymeric micelles have great potential in drug delivery systems because of their multifunctional adjustability, excellent stability, and biocompatibility. To further increase the drug loading efficiency and controlled release ability, a pH-responsive hyperbranched copolymer methoxy poly(ethylene glycol)-
b
-polyethyleneimine-poly(
N
-Cbz-
l
-lysine) (MPEG-PEI-PBLL) was synthesized successfully. MPEG-PEI-NH
2
was synthesized to initiate the ring-opening polymerization of benzyloxycarbonyl substituted lysine
N
-carboxyanhydride (
Z
-lys NCA). The introduction of Schiff bases in the polymer make it possible to respond to the variation of pH values, which cleaved at pH 5.0 while stable at pH 7.4. As the polymer was amphiphilic, MPEG-PEI-PBLL could self-assemble into micelles. Owing to the introduction of PEI, which make the copolymer hyperbranched, the pH-responsive micelles could efficiently encapsulate theranostic agents, such as doxorubicin (DOX) for chemotherapy and NIRF dye DiD for
in vivo
near-infrared (NIR) imaging. The drug delivery system prolonged the drug circulation time in blood and allowed the drug accumulate effectively at the tumor site. Following the guidance, the DOX was applied in chemotherapy to achieve cancer therapeutic efficiency. All the results demonstrate that the polymer micelles have great potential for cancer theranostics.
Polymeric micelles have great potential in drug delivery systems because of their multifunctional adjustability, excellent stability, and biocompatibility.</abstract><cop>CAMBRIDGE</cop><pub>Royal Soc Chemistry</pub><pmid>35492972</pmid><doi>10.1039/d0ra01241f</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5321-8888</orcidid><orcidid>https://orcid.org/0000-0001-5597-6762</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biocompatibility Blood circulation Cancer Chemistry Chemistry, Multidisciplinary Chemotherapy Control stability Controlled release Copolymers Doxorubicin Drug carriers Drug delivery systems Imines Infrared imaging Lysine Micelles MPEG encoders Physical Sciences Polyethylene glycol Polyethyleneimine Polymers Polypeptides Ring opening polymerization Science & Technology Toxicity |
| title | pH-Responsive hyperbranched polypeptides based on Schiff bases as drug carriers for reducing toxicity of chemotherapy |
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