Piperlongumine inhibits cell growth and enhances TRAIL-induced apoptosis in prostate cancer cells

Objective: To investigate whether piperlongumine can sensitize prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and trigger apoptosis in prostate cells.Methods: Human prostate cancer cell lines PC3, LNCaP, and VCaP were cultured with piperlongumine and TRAIL....

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Veröffentlicht in:	Asian Pacific journal of tropical biomedicine 2020-05, Vol.10 (5), p.216-223
Hauptverfasser:	Kismali, Gorkem, Ceylan, Ahmet, Meral, Ogunc, Alpay, Merve, Kosova, Funda, Cakir, Dilek, Yurdakok-Dikmen, Begum, Tascene, Neslihan, Sel, Tevhide
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer cells COX-2 inhibitors EDTA Necrosis piperlongumine prostate cancer apoptosis tumor necrosis factor-related apoptosis-inducing ligand Prostate cancer Tumor necrosis factor Tumors
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Zusammenfassung:	Objective: To investigate whether piperlongumine can sensitize prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and trigger apoptosis in prostate cells.Methods: Human prostate cancer cell lines PC3, LNCaP, and VCaP were cultured with piperlongumine and TRAIL. Then, cell proliferation, migration, caspase activation, apoptotic protein expressions, and death receptor expressions were measured. Results: Piperlongumine inhibited cell proliferation at low doses (
ISSN:	2221-1691 2588-9222
DOI:	10.4103/2221-1691.281465