Iron-Catalyzed Alkylazidation of 1,1-Disubstituted Alkenes with Diacylperoxides and TMSN3
An iron-catalyzed radical alkylazidation of electron-deficient alkenes is reported. Alkyl diacyl peroxides work as the alkyl source, and trimethylsilyl azide acts as the azido reservoir. This method features mild reaction conditions, wide substrate scope, and good functional group tolerance, providi...
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| Veröffentlicht in: | Organic letters 2020-04, Vol.22 (8), p.3195-3199 |
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| container_title | Organic letters |
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| creator | Wei, Rongbiao Xiong, Haigen Ye, Changqing Li, Yajun Bao, Hongli |
| description | An iron-catalyzed radical alkylazidation of electron-deficient alkenes is reported. Alkyl diacyl peroxides work as the alkyl source, and trimethylsilyl azide acts as the azido reservoir. This method features mild reaction conditions, wide substrate scope, and good functional group tolerance, providing a range of α-azido esters, an α-azido ketone, and an α-azido cyanide in high yields. These azides can be easily transferred into many kinds of amino acid derivatives. |
| doi_str_mv | 10.1021/acs.orglett.0c00969 |
| format | Article |
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| source | ACS Publications; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Chemistry Chemistry, Organic Physical Sciences Science & Technology |
| title | Iron-Catalyzed Alkylazidation of 1,1-Disubstituted Alkenes with Diacylperoxides and TMSN3 |
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