Therapeutic cobalt ion incorporated in poly(vinyl alcohol)/bioactive glass scaffolds for tissue engineering
Hybrid scaffolds appear as a promising strategy to accelerate bone tissue repair due to their biocompatibility and to combine physical, mechanical and biological characteristics similar to those of human bone tissue. However, there are no studies in hybrid scaffolds using the sol–gel method and a fo...
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| Veröffentlicht in: | Journal of materials science 2020-07, Vol.55 (20), p.8710-8727 |
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| creator | de Laia, Andréia Grossi Santos Barrioni, Breno Rocha Valverde, Thalita Marcolan de Goes, Alfredo Miranda de Sá, Marcos Augusto Pereira, Marivalda de Magalhães |
| description | Hybrid scaffolds appear as a promising strategy to accelerate bone tissue repair due to their biocompatibility and to combine physical, mechanical and biological characteristics similar to those of human bone tissue. However, there are no studies in hybrid scaffolds using the sol–gel method and a foaming system, with the direct incorporation of cobalt therapeutic ion. In this work, novel porous polyvinyl alcohol polymer (PVA)/bioactive glasses (BG) hybrids scaffolds containing cobalt were obtained, combining the PVA non-toxicity, non-carcinogenicity and processability to the BG bioactivity and osteogenic properties and Co angiogenic effect by the sol–gel and foaming processing method, in order to obtain a new scaffold with angiogenic properties. The effects of Co incorporation on scaffold structure, bioactivity and ion release were evaluated. Cell viability and cell growth assay were performed on human umbilical vein endothelial cells, demonstrating excellent mitochondrial activity without cytotoxicity and cell-friendly environment. Hybrid scaffolds supported fast ion release and an elastic modulus of 20.19 MPa. The presence of cobalt was confirmed by SEM and EDS. Co-incorporated samples showed high porosity and favorable pore size. PVA–BG hybrid scaffolds containing Co showed ionic release rate in the therapeutic range and are promising for angiogenesis in tissue engineering applications. |
| doi_str_mv | 10.1007/s10853-020-04644-0 |
| format | Article |
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However, there are no studies in hybrid scaffolds using the sol–gel method and a foaming system, with the direct incorporation of cobalt therapeutic ion. In this work, novel porous polyvinyl alcohol polymer (PVA)/bioactive glasses (BG) hybrids scaffolds containing cobalt were obtained, combining the PVA non-toxicity, non-carcinogenicity and processability to the BG bioactivity and osteogenic properties and Co angiogenic effect by the sol–gel and foaming processing method, in order to obtain a new scaffold with angiogenic properties. The effects of Co incorporation on scaffold structure, bioactivity and ion release were evaluated. Cell viability and cell growth assay were performed on human umbilical vein endothelial cells, demonstrating excellent mitochondrial activity without cytotoxicity and cell-friendly environment. Hybrid scaffolds supported fast ion release and an elastic modulus of 20.19 MPa. The presence of cobalt was confirmed by SEM and EDS. Co-incorporated samples showed high porosity and favorable pore size. PVA–BG hybrid scaffolds containing Co showed ionic release rate in the therapeutic range and are promising for angiogenesis in tissue engineering applications.</description><identifier>ISSN: 0022-2461</identifier><identifier>EISSN: 1573-4803</identifier><identifier>DOI: 10.1007/s10853-020-04644-0</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biocompatibility ; Bioglass ; Biological activity ; Biomedical materials ; Bones ; Carcinogenicity ; Carcinogens ; Characterization and Evaluation of Materials ; Chemistry and Materials Science ; Classical Mechanics ; Cobalt ; Crystallography and Scattering Methods ; Endothelial cells ; Ethylenediaminetetraacetic acid ; Foaming ; Health aspects ; Human performance ; Incorporation ; Materials for Life Sciences ; Materials Science ; Materials Science, Multidisciplinary ; Modulus of elasticity ; Polymer Sciences ; Polyvinyl alcohol ; Pore size ; Porosity ; Scaffolds ; Science & Technology ; Sol-gel processes ; Solid Mechanics ; Technology ; Tissue engineering ; Toxicity</subject><ispartof>Journal of materials science, 2020-07, Vol.55 (20), p.8710-8727</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>27</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000526241800005</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c395t-fc780417e0cdbe2672970d6c4e706db7faf4d290d1423dd67c44531a729525803</citedby><cites>FETCH-LOGICAL-c395t-fc780417e0cdbe2672970d6c4e706db7faf4d290d1423dd67c44531a729525803</cites><orcidid>0000-0003-0858-6061 ; 0000-0002-8681-6451</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10853-020-04644-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10853-020-04644-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,28255,41495,42564,51326</link.rule.ids></links><search><creatorcontrib>de Laia, Andréia Grossi Santos</creatorcontrib><creatorcontrib>Barrioni, Breno Rocha</creatorcontrib><creatorcontrib>Valverde, Thalita Marcolan</creatorcontrib><creatorcontrib>de Goes, Alfredo Miranda</creatorcontrib><creatorcontrib>de Sá, Marcos Augusto</creatorcontrib><creatorcontrib>Pereira, Marivalda de Magalhães</creatorcontrib><title>Therapeutic cobalt ion incorporated in poly(vinyl alcohol)/bioactive glass scaffolds for tissue engineering</title><title>Journal of materials science</title><addtitle>J Mater Sci</addtitle><addtitle>J MATER SCI</addtitle><description>Hybrid scaffolds appear as a promising strategy to accelerate bone tissue repair due to their biocompatibility and to combine physical, mechanical and biological characteristics similar to those of human bone tissue. However, there are no studies in hybrid scaffolds using the sol–gel method and a foaming system, with the direct incorporation of cobalt therapeutic ion. In this work, novel porous polyvinyl alcohol polymer (PVA)/bioactive glasses (BG) hybrids scaffolds containing cobalt were obtained, combining the PVA non-toxicity, non-carcinogenicity and processability to the BG bioactivity and osteogenic properties and Co angiogenic effect by the sol–gel and foaming processing method, in order to obtain a new scaffold with angiogenic properties. The effects of Co incorporation on scaffold structure, bioactivity and ion release were evaluated. Cell viability and cell growth assay were performed on human umbilical vein endothelial cells, demonstrating excellent mitochondrial activity without cytotoxicity and cell-friendly environment. Hybrid scaffolds supported fast ion release and an elastic modulus of 20.19 MPa. The presence of cobalt was confirmed by SEM and EDS. Co-incorporated samples showed high porosity and favorable pore size. PVA–BG hybrid scaffolds containing Co showed ionic release rate in the therapeutic range and are promising for angiogenesis in tissue engineering applications.</description><subject>Biocompatibility</subject><subject>Bioglass</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>Bones</subject><subject>Carcinogenicity</subject><subject>Carcinogens</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry and Materials Science</subject><subject>Classical Mechanics</subject><subject>Cobalt</subject><subject>Crystallography and Scattering Methods</subject><subject>Endothelial cells</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Foaming</subject><subject>Health aspects</subject><subject>Human performance</subject><subject>Incorporation</subject><subject>Materials for Life Sciences</subject><subject>Materials Science</subject><subject>Materials Science, Multidisciplinary</subject><subject>Modulus of elasticity</subject><subject>Polymer Sciences</subject><subject>Polyvinyl alcohol</subject><subject>Pore size</subject><subject>Porosity</subject><subject>Scaffolds</subject><subject>Science & Technology</subject><subject>Sol-gel processes</subject><subject>Solid Mechanics</subject><subject>Technology</subject><subject>Tissue engineering</subject><subject>Toxicity</subject><issn>0022-2461</issn><issn>1573-4803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkctu1DAUhi0EEsPAC7CKxAaE0h5fEk-W1ahcpEpsytpy7OOpS2oH2ymat8chCHYIeXHso-_3ufyEvKZwQQHkZaZw6HgLDFoQvRAtPCE72kneigPwp2QHwFjLRE-fkxc53wNAJxndkW-3d5j0jEvxpjFx1FNpfAyNDyamOSZd0NZHM8fp_PbRh_PU6MnEuzi9uxx91Kb4R2xOk865yUY7FyebGxdTU3zOCzYYTj4gJh9OL8kzp6eMr37HPfn64fr2-Km9-fLx8_HqpjV86ErrjDyAoBLB2BFZL9kgwfZGoITejtJpJywbwFLBuLW9NEJ0nOrKdayr4-7Jm-3fOcXvC-ai7uOSQi2pGB8YGzhnrFIXG3XSEyofXCxJm3osPngTAzpf81c9ox2IoVbYE7YJTIo5J3RqTv5Bp7OioFYX1OaCqi6oXy6otZfDJvqBY3TZeAwG_whXG1jPBD3Aej36okvd_jEuoVTp-_-XVppvdJ7XXWP6O_Q_2vsJU1SrdA</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>de Laia, Andréia Grossi Santos</creator><creator>Barrioni, Breno Rocha</creator><creator>Valverde, Thalita Marcolan</creator><creator>de Goes, Alfredo Miranda</creator><creator>de Sá, Marcos Augusto</creator><creator>Pereira, Marivalda de Magalhães</creator><general>Springer US</general><general>Springer Nature</general><general>Springer</general><general>Springer Nature B.V</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><orcidid>https://orcid.org/0000-0003-0858-6061</orcidid><orcidid>https://orcid.org/0000-0002-8681-6451</orcidid></search><sort><creationdate>20200701</creationdate><title>Therapeutic cobalt ion incorporated in poly(vinyl alcohol)/bioactive glass scaffolds for tissue engineering</title><author>de Laia, Andréia Grossi Santos ; Barrioni, Breno Rocha ; Valverde, Thalita Marcolan ; de Goes, Alfredo Miranda ; de Sá, Marcos Augusto ; Pereira, Marivalda de Magalhães</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-fc780417e0cdbe2672970d6c4e706db7faf4d290d1423dd67c44531a729525803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biocompatibility</topic><topic>Bioglass</topic><topic>Biological activity</topic><topic>Biomedical materials</topic><topic>Bones</topic><topic>Carcinogenicity</topic><topic>Carcinogens</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry and Materials Science</topic><topic>Classical Mechanics</topic><topic>Cobalt</topic><topic>Crystallography and Scattering Methods</topic><topic>Endothelial cells</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Foaming</topic><topic>Health aspects</topic><topic>Human performance</topic><topic>Incorporation</topic><topic>Materials for Life Sciences</topic><topic>Materials Science</topic><topic>Materials Science, Multidisciplinary</topic><topic>Modulus of elasticity</topic><topic>Polymer Sciences</topic><topic>Polyvinyl alcohol</topic><topic>Pore size</topic><topic>Porosity</topic><topic>Scaffolds</topic><topic>Science & Technology</topic><topic>Sol-gel processes</topic><topic>Solid Mechanics</topic><topic>Technology</topic><topic>Tissue engineering</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Laia, Andréia Grossi Santos</creatorcontrib><creatorcontrib>Barrioni, Breno Rocha</creatorcontrib><creatorcontrib>Valverde, Thalita Marcolan</creatorcontrib><creatorcontrib>de Goes, Alfredo Miranda</creatorcontrib><creatorcontrib>de Sá, Marcos Augusto</creatorcontrib><creatorcontrib>Pereira, Marivalda de Magalhães</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><jtitle>Journal of materials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Laia, Andréia Grossi Santos</au><au>Barrioni, Breno Rocha</au><au>Valverde, Thalita Marcolan</au><au>de Goes, Alfredo Miranda</au><au>de Sá, Marcos Augusto</au><au>Pereira, Marivalda de Magalhães</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic cobalt ion incorporated in poly(vinyl alcohol)/bioactive glass scaffolds for tissue engineering</atitle><jtitle>Journal of materials science</jtitle><stitle>J Mater Sci</stitle><stitle>J MATER SCI</stitle><date>2020-07-01</date><risdate>2020</risdate><volume>55</volume><issue>20</issue><spage>8710</spage><epage>8727</epage><pages>8710-8727</pages><issn>0022-2461</issn><eissn>1573-4803</eissn><abstract>Hybrid scaffolds appear as a promising strategy to accelerate bone tissue repair due to their biocompatibility and to combine physical, mechanical and biological characteristics similar to those of human bone tissue. However, there are no studies in hybrid scaffolds using the sol–gel method and a foaming system, with the direct incorporation of cobalt therapeutic ion. In this work, novel porous polyvinyl alcohol polymer (PVA)/bioactive glasses (BG) hybrids scaffolds containing cobalt were obtained, combining the PVA non-toxicity, non-carcinogenicity and processability to the BG bioactivity and osteogenic properties and Co angiogenic effect by the sol–gel and foaming processing method, in order to obtain a new scaffold with angiogenic properties. The effects of Co incorporation on scaffold structure, bioactivity and ion release were evaluated. Cell viability and cell growth assay were performed on human umbilical vein endothelial cells, demonstrating excellent mitochondrial activity without cytotoxicity and cell-friendly environment. Hybrid scaffolds supported fast ion release and an elastic modulus of 20.19 MPa. The presence of cobalt was confirmed by SEM and EDS. Co-incorporated samples showed high porosity and favorable pore size. PVA–BG hybrid scaffolds containing Co showed ionic release rate in the therapeutic range and are promising for angiogenesis in tissue engineering applications.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10853-020-04644-0</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0003-0858-6061</orcidid><orcidid>https://orcid.org/0000-0002-8681-6451</orcidid></addata></record> |
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| subjects | Biocompatibility Bioglass Biological activity Biomedical materials Bones Carcinogenicity Carcinogens Characterization and Evaluation of Materials Chemistry and Materials Science Classical Mechanics Cobalt Crystallography and Scattering Methods Endothelial cells Ethylenediaminetetraacetic acid Foaming Health aspects Human performance Incorporation Materials for Life Sciences Materials Science Materials Science, Multidisciplinary Modulus of elasticity Polymer Sciences Polyvinyl alcohol Pore size Porosity Scaffolds Science & Technology Sol-gel processes Solid Mechanics Technology Tissue engineering Toxicity |
| title | Therapeutic cobalt ion incorporated in poly(vinyl alcohol)/bioactive glass scaffolds for tissue engineering |
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