Rewarding effects of M4 but not M3 muscarinic cholinergic receptor antagonism in the rostromedial tegmental nucleus

•RMTg Tropicamide but not 4-DAMP induces CPP.•RMTg 4-DAMP but not Tropicamide increases locomotion.•RMTg Tropicamide CPP is dopamine-dependent.•Flupenthixol pretreatment reveals RMTg Tropicamide locomotor effects. The rostromedial tegmental nucleus (RMTg) receives inputs from the laterodorsal tegmen...

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Veröffentlicht in:	Behavioural brain research 2020-02, Vol.379, p.112340-112340, Article 112340
Hauptverfasser:	Buie, Nicole, Sodha, Dharm, Scheinman, Sarah B., Steidl, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Animals Behavior, Animal - drug effects Behavioral Sciences Conditioning, Psychological - drug effects Dopamine Dopamine Antagonists - administration & dosage Dopamine Antagonists - pharmacology Flupenthixol Flupenthixol - pharmacology Laterodorsal tegmental nucleus Life Sciences & Biomedicine Locomotion - drug effects Mice Mice, Inbred C57BL Muscarinic Antagonists - administration & dosage Muscarinic Antagonists - pharmacology Neurosciences Neurosciences & Neurology Pedunculopontine tegmental nucleus Piperidines - pharmacology Receptor, Muscarinic M3 - antagonists & inhibitors Receptor, Muscarinic M4 - antagonists & inhibitors Reward Science & Technology Tropicamide - pharmacology Ventral Tegmental Area - drug effects
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