The Footprints of Oxidative Stress and Mitochondrial Impairment in Arsenic Trioxide-Induced Testosterone Release Suppression in Pubertal and Mature F1-Male Balb/c Mice via the Downregulation of 3β-HSD, 17β-HSD, and CYP11a Expression

Exposure to arsenic (AS) causes abnormalities in the reproductive system; however, the precise cellular pathway of AS toxicity on steroidogenesis in developing F1-male mice has not been clearly defined. In this study, paternal mice were treated with arsenic trioxide (As 2 O 3 ; 0, 0.2, 2, and 20 ppm...

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Veröffentlicht in:	Biological trace element research 2020-05, Vol.195 (1), p.125-134
Hauptverfasser:	Ommati, Mohammad Mehdi, Heidari, Reza, Zamiri, Mohammad Javad, Sabouri, Samira, Zaker, Ladan, Farshad, Omid, Jamshidzadeh, Akram, Mousapour, Saeed
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors 17-Hydroxysteroid Dehydrogenases - genetics 17-Hydroxysteroid Dehydrogenases - metabolism Abnormalities Administration, Oral Animals Arsenic Arsenic trioxide Arsenic Trioxide - administration & dosage Arsenic Trioxide - pharmacology Biochemistry Biocompatibility Biological stress Biomarkers Biomedical and Life Sciences Biosynthesis Biotechnology Cell Survival - drug effects Cholesterol Side-Chain Cleavage Enzyme - antagonists & inhibitors Cholesterol Side-Chain Cleavage Enzyme - genetics Cholesterol Side-Chain Cleavage Enzyme - metabolism Cytochrome P450 Cytochromes Cytochromes P450 Dehydrogenase Dehydrogenases Down-Regulation - drug effects Drinking water Gene expression Genes Genetic abnormalities Impairment Leydig cells Leydig Cells - drug effects Leydig Cells - metabolism Life Sciences Male Males Malformations Mice Mice, Inbred BALB C Mitochondria Mitochondria - drug effects Mitochondria - metabolism Nutrition Offspring Oncology Oxidative stress Oxidative Stress - drug effects Procedures Reproductive behaviour Reproductive system Steroidogenesis Testosterone Testosterone - antagonists & inhibitors Testosterone - metabolism Toxicity Weaning
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