Comparative Tolerability of Dopamine D2/3 Receptor Partial Agonists for Schizophrenia

Aripiprazole, brexpiprazole and cariprazine differ from all other second-generation antipsychotics due to partial agonism at the dopamine D2 and D3 receptors. In contrast to aripiprazole, brexpiprazole has lower intrinsic dopamine D2 activity and higher affinity for the serotonin 5-HT1A and 5-HT2A r...

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Veröffentlicht in:	CNS drugs 2020-05, Vol.34 (5), p.473-507
Hauptverfasser:	Keks, Nicholas, Hope, Judith, Schwartz, Darren, McLennan, Harold, Copolov, David, Meadows, Graham
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Affinity Agonists Antipsychotics Aripiprazole Clinical Neurology Diabetes Diabetes mellitus Dopamine Dopamine D2 receptors Dopamine D3 receptors Drug dosages Dyskinesia FDA approval Impulsive behavior Life expectancy Life Sciences & Biomedicine Medicine Medicine & Public Health Mental disorders Metabolic syndrome Mortality Movement disorders Nausea Neurology Neurosciences Neurosciences & Neurology Pharmaceutical industry Pharmacology Pharmacology & Pharmacy Pharmacotherapy Prolactin Psychiatry Psychopharmacology Psychotropic drugs Review Article Schizophrenia Science & Technology Serotonin S1 receptors Serotonin S2 receptors Side effects Sleep disorders Tardive dyskinesia
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