Nanofibrous silica microparticles/polymer hybrid aerogels for sustained delivery of poorly water-soluble camptothecin

[Display omitted] •Hybrid aerogels to deliver a poorly water-soluble anticancer drug are developed.•They contain methyl-decorated nanofibrous silica microparticles and two polymers.•The hybrid aerogels can effectively load and deliver a payload of camptothecin.•The aerogels sustainably release CPT f...

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Veröffentlicht in:	Journal of colloid and interface science 2020-05, Vol.567, p.92-102
Hauptverfasser:	Follmann, Heveline D.M., Oliveira, Osvaldo N., Martins, Alessandro C., Lazarin-Bidóia, Danielle, Nakamura, Celso V., Rubira, Adley F., Silva, Rafael, Asefa, Tewodros
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemistry Aerogels Animals Anticancer drug release Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biocompatible Materials - chemistry Camptothecin Camptothecin - chemistry Camptothecin - pharmacology Cell Line Cell Proliferation - drug effects Chemistry Chemistry, Physical Drug Delivery Systems Drug Liberation Drug Screening Assays, Antitumor Gels - chemistry Humans Hybrid material Mice Molecular Structure Nanofibers - chemistry Nanofibrous silica Particle Size Physical Sciences Polyvinyl Alcohol - chemistry Science & Technology Silicon Dioxide - chemistry Solubility Surface Properties
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