APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1 and APOL3 are death-promoting proteins that are partially associated with the endoplasmic reticul...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-03, Vol.30 (11), p.3821-3836.e13
Hauptverfasser:	Uzureau, Sophie, Lecordier, Laurence, Uzureau, Pierrick, Hennig, Dorle, Graversen, Jonas H., Homblé, Fabrice, Mfutu, Pepe Ekulu, Oliveira Arcolino, Fanny, Ramos, Ana Raquel, La Rovere, Rita M., Luyten, Tomas, Vermeersch, Marjorie, Tebabi, Patricia, Dieu, Marc, Cuypers, Bart, Deborggraeve, Stijn, Rabant, Marion, Legendre, Christophe, Moestrup, Søren K., Levtchenko, Elena, Bultynck, Geert, Erneux, Christophe, Pérez-Morga, David, Pays, Etienne
Format:	Artikel
Sprache:	eng
Schlagworte:	Actomyosin Actomyosin - metabolism actomyosin cytoskeleton Amino Acid Sequence APOL1 APOL3 Apolipoprotein L1 Apolipoprotein L1 - chemistry Apolipoprotein L1 - genetics Apolipoprotein L1 - urine Apolipoproteins L Apolipoproteins L - metabolism Calcium Calcium - metabolism Cell Line Cellular Biology Endoplasmic Reticulum Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - ultrastructure Golgi Apparatus Golgi Apparatus - drug effects Golgi Apparatus - metabolism Golgi Apparatus - ultrastructure Humans kidney disease Kidney Diseases Kidney Diseases - metabolism Kidney Diseases - urine Kidney Glomerulus Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Life Sciences Minor Histocompatibility Antigens Minor Histocompatibility Antigens - metabolism Mutation Mutation - genetics MYH9 NCS-1 Neuronal Calcium-Sensor Proteins Neuronal Calcium-Sensor Proteins - metabolism Neuropeptides Neuropeptides - metabolism Phenotype Phosphatidylinositol Phosphates Phosphatidylinositol Phosphates - metabolism phosphoinositide control Phosphotransferases (Alcohol Group Acceptor) Phosphotransferases (Alcohol Group Acceptor) - metabolism PI4KB Podocytes Podocytes - drug effects Podocytes - metabolism Podocytes - ultrastructure Poly I-C Poly I-C - pharmacology Potassium Channels Potassium Channels - metabolism Protein Binding Protein Binding - drug effects Protein Structure, Secondary sleeping sickness
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