Prophylactic Antibiotics for Reducing Central Line-associated Blood Stream Infection in Children with Totally Implantable Venous Access Devices
Objective: To analyse the need of prophylactic antibiotic before the insertion of totally implantable venous access devices (TIVADs) in terms of preventing central line-associated blood stream infection (CLABSI) in early postoperative period in pediatric oncology patients. Study Design: A cohort stu...
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| Veröffentlicht in: | Journal of the College of Physicians and Surgeons--Pakistan 2020-03, Vol.30 (3), p.304-308 |
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| container_title | Journal of the College of Physicians and Surgeons--Pakistan |
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| creator | Akbar, Sana Amir Qudsia, Zoona Feroza Ashraf, Muhammad Nabeel Tarar, Mansoor Ahmad Qazi, Abid Quddus |
| description | Objective: To analyse the need of prophylactic antibiotic before the insertion of totally implantable venous access devices (TIVADs) in terms of preventing central line-associated blood stream infection (CLABSI) in early postoperative period in pediatric oncology patients.
Study Design: A cohort study.
Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore from January 2005 to June 2016.
Methodology: A total of 645 consecutive children with malignancy, who were implanted with TIVAD, were included in the study. The data were collected retrospectively and divided into two groups on the basis of prophylactic antibiotic administration (Group A) received the antibiotic; and Group B did not receive the antibiotic. Both the groups were compared in terms of positive central blood cultures in the absence of any other clinical source of infection during the early post-operative period of 30 days.
Results: The overall infection rate was 12.54% (35 out of 279) in Group B (did not receive prophylactic antibiotic) and 11.68% (41 out of 351) in Group A (received prophylactic antibiotic) without any significant difference (p = 0.741).
Conclusion: There was no advantage of the use of prophylactic antibiotic before TIVAD insertion in preventing early postoperative CLABSI. |
| doi_str_mv | 10.29271/jcpsp.2020.03.304 |
| format | Article |
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Study Design: A cohort study.
Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore from January 2005 to June 2016.
Methodology: A total of 645 consecutive children with malignancy, who were implanted with TIVAD, were included in the study. The data were collected retrospectively and divided into two groups on the basis of prophylactic antibiotic administration (Group A) received the antibiotic; and Group B did not receive the antibiotic. Both the groups were compared in terms of positive central blood cultures in the absence of any other clinical source of infection during the early post-operative period of 30 days.
Results: The overall infection rate was 12.54% (35 out of 279) in Group B (did not receive prophylactic antibiotic) and 11.68% (41 out of 351) in Group A (received prophylactic antibiotic) without any significant difference (p = 0.741).
Conclusion: There was no advantage of the use of prophylactic antibiotic before TIVAD insertion in preventing early postoperative CLABSI.</description><identifier>ISSN: 1022-386X</identifier><identifier>EISSN: 1681-7168</identifier><identifier>DOI: 10.29271/jcpsp.2020.03.304</identifier><identifier>PMID: 32169141</identifier><language>eng</language><publisher>KARACHI: Coll Physicians & Surgeons Pakistan</publisher><subject><![CDATA[Age Factors ; Antibiotic Prophylaxis ; Antibiotics ; Bacteremia - prevention & control ; Blood tests ; Catheter-Related Infections - prevention & control ; Catheterization, Central Venous - adverse effects ; Central Venous Catheters - adverse effects ; Child ; Child, Preschool ; Female ; General & Internal Medicine ; Humans ; Infection ; Life Sciences & Biomedicine ; Male ; Medicine, General & Internal ; Pakistan ; Prostheses and implants ; Retrospective Studies ; Science & Technology]]></subject><ispartof>Journal of the College of Physicians and Surgeons--Pakistan, 2020-03, Vol.30 (3), p.304-308</ispartof><rights>COPYRIGHT 2020 College of Physicians and Surgeons Pakistan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>2</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000520024700016</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c414t-a127d3d935064d91e1748fcc5b39f8fe5c53a5062e0c7704dd605820d90bcef53</citedby><cites>FETCH-LOGICAL-c414t-a127d3d935064d91e1748fcc5b39f8fe5c53a5062e0c7704dd605820d90bcef53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32169141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akbar, Sana Amir</creatorcontrib><creatorcontrib>Qudsia, Zoona Feroza</creatorcontrib><creatorcontrib>Ashraf, Muhammad Nabeel</creatorcontrib><creatorcontrib>Tarar, Mansoor Ahmad</creatorcontrib><creatorcontrib>Qazi, Abid Quddus</creatorcontrib><title>Prophylactic Antibiotics for Reducing Central Line-associated Blood Stream Infection in Children with Totally Implantable Venous Access Devices</title><title>Journal of the College of Physicians and Surgeons--Pakistan</title><addtitle>JCPSP-J COLL PHYSICI</addtitle><addtitle>J Coll Physicians Surg Pak</addtitle><description>Objective: To analyse the need of prophylactic antibiotic before the insertion of totally implantable venous access devices (TIVADs) in terms of preventing central line-associated blood stream infection (CLABSI) in early postoperative period in pediatric oncology patients.
Study Design: A cohort study.
Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore from January 2005 to June 2016.
Methodology: A total of 645 consecutive children with malignancy, who were implanted with TIVAD, were included in the study. The data were collected retrospectively and divided into two groups on the basis of prophylactic antibiotic administration (Group A) received the antibiotic; and Group B did not receive the antibiotic. Both the groups were compared in terms of positive central blood cultures in the absence of any other clinical source of infection during the early post-operative period of 30 days.
Results: The overall infection rate was 12.54% (35 out of 279) in Group B (did not receive prophylactic antibiotic) and 11.68% (41 out of 351) in Group A (received prophylactic antibiotic) without any significant difference (p = 0.741).
Conclusion: There was no advantage of the use of prophylactic antibiotic before TIVAD insertion in preventing early postoperative CLABSI.</description><subject>Age Factors</subject><subject>Antibiotic Prophylaxis</subject><subject>Antibiotics</subject><subject>Bacteremia - prevention & control</subject><subject>Blood tests</subject><subject>Catheter-Related Infections - prevention & control</subject><subject>Catheterization, Central Venous - adverse effects</subject><subject>Central Venous Catheters - adverse effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>General & Internal Medicine</subject><subject>Humans</subject><subject>Infection</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medicine, General & Internal</subject><subject>Pakistan</subject><subject>Prostheses and implants</subject><subject>Retrospective Studies</subject><subject>Science & Technology</subject><issn>1022-386X</issn><issn>1681-7168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkV-L1DAUxYso7rr6BXyQgC-CdLxJ2qZ9HOu_gQFFV_GtpMnNbpY0qU3GZT6FX9nMzrog-CCB5JD8zuWQUxRPKaxYxwR9daXmOK8YMFgBX3Go7hWntGlpKfJ-P2tgrORt8_2keBTjFQCvads-LE44o01HK3pa_Pq0hPly76RKVpG1T3a0IctITFjIZ9Q7Zf0F6dGnRTqytR5LGWNQVibU5LULQZMvaUE5kY03mMcET6wn_aV1ekFPrm26JOchSef2ZDPNTvokR4fkG_qwi2StFMZI3uBPm8Xj4oGRLuKT2_Os-Pru7Xn_odx-fL_p19tSVbRKpaRMaK47XkNT6Y4iFVVrlKpH3pnWYK1qLvMbQ1BCQKV1A3XLQHcwKjQ1PyteHOfOS_ixw5iGyUaFLqfDnGpgXAjOm6rtMvr8iF5Ih4P1JuSvUAd8WDeMViAE45la_YPKS-NkVfBobL7_y8COBrWEGBc0w7zYSS77gcJw0-9w0-9w6HcAPuR-s-nZbezdOKG-s_wpNAPtEbjGMZioLHqFdxgA1AyAVSIr2vQ2yUNffdj5lK0v_9_KfwNxvcNa</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Akbar, Sana Amir</creator><creator>Qudsia, Zoona Feroza</creator><creator>Ashraf, Muhammad Nabeel</creator><creator>Tarar, Mansoor Ahmad</creator><creator>Qazi, Abid Quddus</creator><general>Coll Physicians & Surgeons Pakistan</general><general>College of Physicians and Surgeons Pakistan</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200301</creationdate><title>Prophylactic Antibiotics for Reducing Central Line-associated Blood Stream Infection in Children with Totally Implantable Venous Access Devices</title><author>Akbar, Sana Amir ; Qudsia, Zoona Feroza ; Ashraf, Muhammad Nabeel ; Tarar, Mansoor Ahmad ; Qazi, Abid Quddus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-a127d3d935064d91e1748fcc5b39f8fe5c53a5062e0c7704dd605820d90bcef53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age Factors</topic><topic>Antibiotic Prophylaxis</topic><topic>Antibiotics</topic><topic>Bacteremia - prevention & control</topic><topic>Blood tests</topic><topic>Catheter-Related Infections - prevention & control</topic><topic>Catheterization, Central Venous - adverse effects</topic><topic>Central Venous Catheters - adverse effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>General & Internal Medicine</topic><topic>Humans</topic><topic>Infection</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medicine, General & Internal</topic><topic>Pakistan</topic><topic>Prostheses and implants</topic><topic>Retrospective Studies</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akbar, Sana Amir</creatorcontrib><creatorcontrib>Qudsia, Zoona Feroza</creatorcontrib><creatorcontrib>Ashraf, Muhammad Nabeel</creatorcontrib><creatorcontrib>Tarar, Mansoor Ahmad</creatorcontrib><creatorcontrib>Qazi, Abid Quddus</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akbar, Sana Amir</au><au>Qudsia, Zoona Feroza</au><au>Ashraf, Muhammad Nabeel</au><au>Tarar, Mansoor Ahmad</au><au>Qazi, Abid Quddus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prophylactic Antibiotics for Reducing Central Line-associated Blood Stream Infection in Children with Totally Implantable Venous Access Devices</atitle><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle><stitle>JCPSP-J COLL PHYSICI</stitle><addtitle>J Coll Physicians Surg Pak</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>30</volume><issue>3</issue><spage>304</spage><epage>308</epage><pages>304-308</pages><issn>1022-386X</issn><eissn>1681-7168</eissn><abstract>Objective: To analyse the need of prophylactic antibiotic before the insertion of totally implantable venous access devices (TIVADs) in terms of preventing central line-associated blood stream infection (CLABSI) in early postoperative period in pediatric oncology patients.
Study Design: A cohort study.
Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore from January 2005 to June 2016.
Methodology: A total of 645 consecutive children with malignancy, who were implanted with TIVAD, were included in the study. The data were collected retrospectively and divided into two groups on the basis of prophylactic antibiotic administration (Group A) received the antibiotic; and Group B did not receive the antibiotic. Both the groups were compared in terms of positive central blood cultures in the absence of any other clinical source of infection during the early post-operative period of 30 days.
Results: The overall infection rate was 12.54% (35 out of 279) in Group B (did not receive prophylactic antibiotic) and 11.68% (41 out of 351) in Group A (received prophylactic antibiotic) without any significant difference (p = 0.741).
Conclusion: There was no advantage of the use of prophylactic antibiotic before TIVAD insertion in preventing early postoperative CLABSI.</abstract><cop>KARACHI</cop><pub>Coll Physicians & Surgeons Pakistan</pub><pmid>32169141</pmid><doi>10.29271/jcpsp.2020.03.304</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Antibiotic Prophylaxis Antibiotics Bacteremia - prevention & control Blood tests Catheter-Related Infections - prevention & control Catheterization, Central Venous - adverse effects Central Venous Catheters - adverse effects Child Child, Preschool Female General & Internal Medicine Humans Infection Life Sciences & Biomedicine Male Medicine, General & Internal Pakistan Prostheses and implants Retrospective Studies Science & Technology |
| title | Prophylactic Antibiotics for Reducing Central Line-associated Blood Stream Infection in Children with Totally Implantable Venous Access Devices |
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