Effect of Botulinum Toxin A on Bladder Pain-Molecular Evidence and Animal Studies
Botulinum toxin A (BTX-A) is a powerful neurotoxin with long-lasting activity that blocks muscle contractions. In addition to effects on neuromuscular junctions, BTX-A also plays a role in sensory feedback loops, suggesting the potentiality for pain relief. Although the only approved indications for...
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| Veröffentlicht in: | Toxins 2020-02, Vol.12 (2), p.98 |
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| creator | Yeh, Ting-Chun Chen, Po-Cheng Su, Yann-Rong Kuo, Hann-Chorng |
| description | Botulinum toxin A (BTX-A) is a powerful neurotoxin with long-lasting activity that blocks muscle contractions. In addition to effects on neuromuscular junctions, BTX-A also plays a role in sensory feedback loops, suggesting the potentiality for pain relief. Although the only approved indications for BTX-A in the bladder are neurogenic detrusor overactivity and refractory overactive bladder, BTX-A injections to treat bladder pain refractory to conventional therapies are also recommended. The mechanism of BTX-A activity in bladder pain is complex, with several hypotheses proposed in recent studies. Here we comprehensively reviewed properties of BTX-A in peripheral afferent and efferent nerves, the inhibition of nociceptive neurotransmitter release, the reduction of stretch-related visceral pain, and its anti-inflammatory effects on the bladder urothelium. Studies have also revealed possible effects of BTX-A in the human brain. However, further basic and clinical studies are warranted to provide solid evidence-based support in using BTX-A to treat bladder pain. |
| doi_str_mv | 10.3390/toxins12020098 |
| format | Article |
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In addition to effects on neuromuscular junctions, BTX-A also plays a role in sensory feedback loops, suggesting the potentiality for pain relief. Although the only approved indications for BTX-A in the bladder are neurogenic detrusor overactivity and refractory overactive bladder, BTX-A injections to treat bladder pain refractory to conventional therapies are also recommended. The mechanism of BTX-A activity in bladder pain is complex, with several hypotheses proposed in recent studies. Here we comprehensively reviewed properties of BTX-A in peripheral afferent and efferent nerves, the inhibition of nociceptive neurotransmitter release, the reduction of stretch-related visceral pain, and its anti-inflammatory effects on the bladder urothelium. Studies have also revealed possible effects of BTX-A in the human brain. However, further basic and clinical studies are warranted to provide solid evidence-based support in using BTX-A to treat bladder pain.</description><identifier>ISSN: 2072-6651</identifier><identifier>EISSN: 2072-6651</identifier><identifier>DOI: 10.3390/toxins12020098</identifier><identifier>PMID: 32028597</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Analgesics - pharmacology ; Analgesics - therapeutic use ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; bladder pain ; botulinum toxin a ; Botulinum Toxins, Type A - pharmacology ; Botulinum Toxins, Type A - therapeutic use ; interstitial cystitis ; molecular mechanism ; Neuromuscular Agents - pharmacology ; Neuromuscular Agents - therapeutic use ; Pelvic Pain - drug therapy ; Pelvic Pain - physiopathology ; Review ; Urinary Bladder Diseases - drug therapy ; Urinary Bladder Diseases - physiopathology</subject><ispartof>Toxins, 2020-02, Vol.12 (2), p.98</ispartof><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-35346bfe3501bcec0a416a818a2db6d8f96d9f912a22ca45f42603e6bf8fb523</citedby><cites>FETCH-LOGICAL-c456t-35346bfe3501bcec0a416a818a2db6d8f96d9f912a22ca45f42603e6bf8fb523</cites><orcidid>0000-0002-8897-1375 ; 0000-0001-7165-4771</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076962/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076962/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32028597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeh, Ting-Chun</creatorcontrib><creatorcontrib>Chen, Po-Cheng</creatorcontrib><creatorcontrib>Su, Yann-Rong</creatorcontrib><creatorcontrib>Kuo, Hann-Chorng</creatorcontrib><title>Effect of Botulinum Toxin A on Bladder Pain-Molecular Evidence and Animal Studies</title><title>Toxins</title><addtitle>Toxins (Basel)</addtitle><description>Botulinum toxin A (BTX-A) is a powerful neurotoxin with long-lasting activity that blocks muscle contractions. In addition to effects on neuromuscular junctions, BTX-A also plays a role in sensory feedback loops, suggesting the potentiality for pain relief. Although the only approved indications for BTX-A in the bladder are neurogenic detrusor overactivity and refractory overactive bladder, BTX-A injections to treat bladder pain refractory to conventional therapies are also recommended. The mechanism of BTX-A activity in bladder pain is complex, with several hypotheses proposed in recent studies. Here we comprehensively reviewed properties of BTX-A in peripheral afferent and efferent nerves, the inhibition of nociceptive neurotransmitter release, the reduction of stretch-related visceral pain, and its anti-inflammatory effects on the bladder urothelium. Studies have also revealed possible effects of BTX-A in the human brain. However, further basic and clinical studies are warranted to provide solid evidence-based support in using BTX-A to treat bladder pain.</description><subject>Analgesics - pharmacology</subject><subject>Analgesics - therapeutic use</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>bladder pain</subject><subject>botulinum toxin a</subject><subject>Botulinum Toxins, Type A - pharmacology</subject><subject>Botulinum Toxins, Type A - therapeutic use</subject><subject>interstitial cystitis</subject><subject>molecular mechanism</subject><subject>Neuromuscular Agents - pharmacology</subject><subject>Neuromuscular Agents - therapeutic use</subject><subject>Pelvic Pain - drug therapy</subject><subject>Pelvic Pain - physiopathology</subject><subject>Review</subject><subject>Urinary Bladder Diseases - drug therapy</subject><subject>Urinary Bladder Diseases - physiopathology</subject><issn>2072-6651</issn><issn>2072-6651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNpVkdtKJDEQhoPsoqLeernkBVpz7vTNwijjAVzWxbkPOVTcSE8i6W7ZfXt7HBWnbqqoqv-rgh-hU0rOOO_I-Vj-pTxQRhghnd5Dh4y0rFFK0m9f6gN0MgxPZA7OaUfbfXTAZ4mWXXuI_ixjBD_iEvFFGac-5WmNVxsuXuCS8UVvQ4CK723Kza_Sg596W_HyJQXIHrDNAS9yWtseP4xTSDAco-_R9gOcvOcjtLpari5vmrvf17eXi7vGC6nGhksulIvAJaHOgydWUGU11ZYFp4KOnQpd7CizjHkrZBRMEQ6zREcnGT9Ct1tsKPbJPNf5hfrfFJvMW6PUR2PrmHwPhrvoNHDGuBAiCNDeSeDgKdVEMupm1s8t63lyawge8lhtvwPdneT01zyWF9OSVnVq88zZFuBrGYYK8VNLidlYZXatmgU_vl78XP8whr8CAFKQyg</recordid><startdate>20200203</startdate><enddate>20200203</enddate><creator>Yeh, Ting-Chun</creator><creator>Chen, Po-Cheng</creator><creator>Su, Yann-Rong</creator><creator>Kuo, Hann-Chorng</creator><general>MDPI</general><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8897-1375</orcidid><orcidid>https://orcid.org/0000-0001-7165-4771</orcidid></search><sort><creationdate>20200203</creationdate><title>Effect of Botulinum Toxin A on Bladder Pain-Molecular Evidence and Animal Studies</title><author>Yeh, Ting-Chun ; Chen, Po-Cheng ; Su, Yann-Rong ; Kuo, Hann-Chorng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-35346bfe3501bcec0a416a818a2db6d8f96d9f912a22ca45f42603e6bf8fb523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analgesics - pharmacology</topic><topic>Analgesics - therapeutic use</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>bladder pain</topic><topic>botulinum toxin a</topic><topic>Botulinum Toxins, Type A - pharmacology</topic><topic>Botulinum Toxins, Type A - therapeutic use</topic><topic>interstitial cystitis</topic><topic>molecular mechanism</topic><topic>Neuromuscular Agents - pharmacology</topic><topic>Neuromuscular Agents - therapeutic use</topic><topic>Pelvic Pain - drug therapy</topic><topic>Pelvic Pain - physiopathology</topic><topic>Review</topic><topic>Urinary Bladder Diseases - drug therapy</topic><topic>Urinary Bladder Diseases - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeh, Ting-Chun</creatorcontrib><creatorcontrib>Chen, Po-Cheng</creatorcontrib><creatorcontrib>Su, Yann-Rong</creatorcontrib><creatorcontrib>Kuo, Hann-Chorng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Toxins</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeh, Ting-Chun</au><au>Chen, Po-Cheng</au><au>Su, Yann-Rong</au><au>Kuo, Hann-Chorng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Botulinum Toxin A on Bladder Pain-Molecular Evidence and Animal Studies</atitle><jtitle>Toxins</jtitle><addtitle>Toxins (Basel)</addtitle><date>2020-02-03</date><risdate>2020</risdate><volume>12</volume><issue>2</issue><spage>98</spage><pages>98-</pages><issn>2072-6651</issn><eissn>2072-6651</eissn><abstract>Botulinum toxin A (BTX-A) is a powerful neurotoxin with long-lasting activity that blocks muscle contractions. In addition to effects on neuromuscular junctions, BTX-A also plays a role in sensory feedback loops, suggesting the potentiality for pain relief. Although the only approved indications for BTX-A in the bladder are neurogenic detrusor overactivity and refractory overactive bladder, BTX-A injections to treat bladder pain refractory to conventional therapies are also recommended. The mechanism of BTX-A activity in bladder pain is complex, with several hypotheses proposed in recent studies. Here we comprehensively reviewed properties of BTX-A in peripheral afferent and efferent nerves, the inhibition of nociceptive neurotransmitter release, the reduction of stretch-related visceral pain, and its anti-inflammatory effects on the bladder urothelium. Studies have also revealed possible effects of BTX-A in the human brain. However, further basic and clinical studies are warranted to provide solid evidence-based support in using BTX-A to treat bladder pain.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>32028597</pmid><doi>10.3390/toxins12020098</doi><orcidid>https://orcid.org/0000-0002-8897-1375</orcidid><orcidid>https://orcid.org/0000-0001-7165-4771</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Analgesics - pharmacology Analgesics - therapeutic use Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use bladder pain botulinum toxin a Botulinum Toxins, Type A - pharmacology Botulinum Toxins, Type A - therapeutic use interstitial cystitis molecular mechanism Neuromuscular Agents - pharmacology Neuromuscular Agents - therapeutic use Pelvic Pain - drug therapy Pelvic Pain - physiopathology Review Urinary Bladder Diseases - drug therapy Urinary Bladder Diseases - physiopathology |
| title | Effect of Botulinum Toxin A on Bladder Pain-Molecular Evidence and Animal Studies |
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