Discorea nipponica saponins restore the Th17/Treg balance in aplastic anemia through the Notch/RBPJκ/FOXP3/RORγt axis

T cell differentiation is a key pathological process of aplastic anemia (AA). Tregs and Th17 must be balanced for efficient immune tolerance. Discorea nipponica saponins (DNS) improves the recovery from hematopoiesis in AA models through its ability to increase the number of T-helper cells whilst de...

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Veröffentlicht in:	Journal of King Saud University. Science 2020-03, Vol.32 (2), p.1664-1672
Hauptverfasser:	Song, Xinlong, Zhang, Le, Zhang, Shan, Wang, Aidi, Wu, Yuhong, Wang, Xiaohong, Liu, Baoshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aplastic anemia Discorea nipponica saponins Notch pathway T cell differentiation
Online-Zugang:	Volltext
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