Cost-Effectiveness Analysis of Baseline Testing for Resistance-Associated Polymorphisms to Optimize Treatment Outcome in Genotype 1 Noncirrhotic Treatment-Naïve Patients With Chronic Hepatitis C Virus

Direct-acting antivirals containing nonstructural protein 5A (NS5A) inhibitors administered over 8 to 12 weeks are effective in ∼95% of patients with hepatitis C virus. Nevertheless, patients resistant to NS5A inhibitors have lower cure rates over 8 weeks (

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Value in health 2020-02, Vol.23 (2), p.180-190
Hauptverfasser:	Fawsitt, Christopher G., Vickerman, Peter, Cooke, Graham S., Barnes, Eleanor, Ball, Jonathan, Brainard, Diana, Burgess, Gary, Dillon, John, Foster, Graham, Gore, Charles, Guha, Neil, Halford, Rachel, Whitby, Kevin, Holmes, Chris, Howe, Anita, Hudson, Emma, Hutchinson, Sharon, Irving, William, Khakoo, Salim, Klenerman, Paul, Martin, Natasha, Massetto, Benedetta, Mbisa, Tamyo, McHutchison, John, McKeating, Jane, McLauchlan, John, Miners, Alec, Murray, Andrea, Shaw, Peter, Simmonds, Peter, Spencer, Chris, Thomson, Emma, Zitzmann, Nicole, Welton, Nicky J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral agents Antiviral Agents - adverse effects Antiviral Agents - economics Antiviral Agents - therapeutic use Antiviral drugs baseline testing Business & Economics Cost analysis Cost-Benefit Analysis cost-effectiveness Cure Decision Support Techniques Decision Trees Drug Costs Drug prices Drug Resistance, Viral - genetics Economics Female Genotype Genotype & phenotype Genotypes Health Care Sciences & Services Health Policy & Services Health services Hepacivirus - drug effects Hepacivirus - genetics Hepatitis Hepatitis C hepatitis C virus Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - economics Hepatitis C, Chronic - virology Humans Life Sciences & Biomedicine Male Markov Chains Models, Economic Molecular Diagnostic Techniques - economics Molecular Targeted Therapy - economics Polymorphism Polymorphism, Genetic Predictive Value of Tests Prices Quality-Adjusted Life Years Resistance resistance-associated polymorphisms Science & Technology Social Sciences State Medicine - economics Time Factors Treatment Outcome United Kingdom Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Willingness to pay
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Direct-acting antivirals containing nonstructural protein 5A (NS5A) inhibitors administered over 8 to 12 weeks are effective in ∼95% of patients with hepatitis C virus. Nevertheless, patients resistant to NS5A inhibitors have lower cure rates over 8 weeks (
ISSN:	1098-3015 1524-4733
DOI:	10.1016/j.jval.2019.08.012