A rare of Turner syndrome with a special karyotype: a case report

Turner syndrome (TS) is a gonadal dysgenesis caused by absence or structural abnormalities of sex chromosome. Isochromosome Mosaic TS is a structurally abnormal X chromosome consisting of either two short or two long arms, with only an 8-9% prevalence among women with TS based on international studies. The present report describes a 30-year-old female with isochromosome mosaic karyotype TS. The patient had no menarche so far. G-banding chromosome analysis indicated mosaic 45,X[3]/46,X,i(X) (q10)[79]/47,X,i(X) (q10),i(X)(q10),i(X)(q10)[3]/49,X,i(X)(q10),i(X)(q10),i(X)(q10),i(X)(q10)[79]. Both clinical and cytogenetic investigations proved this patient to be a special isochromosome Xq Mosaic TS with autoimmune hypothyroidism and hyperlipidemia.