Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy

Background and Objectives Despite limited evidence, cannabidiol-rich cannabis extracts have been popularly used in pediatrics. With increased use, it is critical to determine basic pharmacokinetic parameters of cannabidiol in these extracts in the pediatric population. The objective of this study wa...

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Veröffentlicht in:	Clinical pharmacokinetics 2020-08, Vol.59 (8), p.1005-1012
Hauptverfasser:	Wang, George Sam, Bourne, David W. A., Klawitter, Jost, Sempio, Cristina, Chapman, Kevin, Knupp, Kelly, Wempe, Michael F., Borgelt, Laura, Christians, Uwe, Leonard, Jan, Heard, Kennon, Bajaj, Lalit
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants Cannabidiol Convulsions & seizures Drug dosages Drug interactions Epilepsy FDA approval Internal Medicine Life Sciences & Biomedicine Medical marijuana Medicine Medicine & Public Health Metabolites Original Research Article Pain Pediatrics Pharmacokinetics Pharmacology & Pharmacy Pharmacology/Toxicology Pharmacotherapy Plasma Public health Science & Technology
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Zusammenfassung:	Background and Objectives Despite limited evidence, cannabidiol-rich cannabis extracts have been popularly used in pediatrics. With increased use, it is critical to determine basic pharmacokinetic parameters of cannabidiol in these extracts in the pediatric population. The objective of this study was to determine the disposition of oral cannabidiol cannabis extracts and drug interactions in children with pediatric epilepsy. Methods We conducted a prospective observational study evaluating the disposition of oral cannabidiol in children (
ISSN:	0312-5963 1179-1926
DOI:	10.1007/s40262-020-00869-z