Single-suture craniosynostosis: is there a correlation between preoperative ophthalmological, neuroradiological, and neurocognitive findings?
Background In spite of literature data stating that children with single-suture craniosynostosis have an increased risk for neuropsychological deficits, no data are present clarifying the potential risk factors. Methods All children with non-syndromic single-suture craniosynostosis operated on from...
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| Veröffentlicht in: | Child's nervous system 2020-07, Vol.36 (7), p.1481-1488 |
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| creator | Chieffo, D. P. R. Arcangeli, V. Bianchi, F. Salerni, A. Massimi, L. Frassanito, P. Tamburrini, G. |
| description | Background
In spite of literature data stating that children with single-suture craniosynostosis have an increased risk for neuropsychological deficits, no data are present clarifying the potential risk factors.
Methods
All children with non-syndromic single-suture craniosynostosis operated on from January 2014 to January 2017 were enrolled. A comprehensive neurocognitive and neuro-ophthalmological evaluation was performed before surgery and 6 months after surgery. A further neurocognitive evaluation was performed 12 months after surgery. All children had a preoperative CT/MR study.
Results
One hundred forty-two patients were enrolled; 87 are affected by sagittal craniosynostosis, 38 by trigonocephaly, and 17 by plagiocephaly. A global neurocognitive impairment was documented in 22/87 children with scaphocephaly, 5/38 children with trigonocephaly, and 6/17 children with anterior plagiocephaly. There was a significant relationship between results of the ophthalmological evaluation, global IQ, and CT findings at diagnosis (
r
= 0.296,
p
|
| doi_str_mv | 10.1007/s00381-020-04521-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000515696000001CitationCount</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2350093471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-72f3f68f486f577359b374849c9094c821b7d1abc7cf64d23bae19d545df7fb73</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhS0EotPCC7BAWSLRwHVsxwkbhEb8SZVYAGvLca5nXGXsYDuM-hC8M-6klB3CG0vH37m-OoeQZxReUQD5OgGwjtbQQA1cNLQ-PiAbyhmrgQl4SDbQiLaWwOGMnKd0DUBF1_SPyRlrAFro5Yb8-ur8bsI6LXmJWJmovQvpxoeUQ3LpTeVSlfdYnnRlQow46eyCrwbMR0RfzRHDjLGIP7EK8z7v9XQIU9g5o6fLyuMSQ9Sj-ytpP66yCTvvTj7r_FjWSG-fkEdWTwmf3t0X5PuH99-2n-qrLx8_b99d1YZxmWvZWGbbzvKutUJKJvqBSd7x3vTQc9M1dJAj1YORxrZ8bNigkfaj4GK00g6SXZAX69w5hh8LpqwOLhmcJu0xLEk1JT_oy1-0oM2KmhhSimjVHN1BxxtFQd3WoNYaVKlBnWpQx2J6fjd_GQ443lv-5F6AbgWOOASbjENv8B4DAEFF27dwe-jW5VPo27D4XKwv_99aaLbSqRB-h1FdhyX6Eu6_9v8NYoS4WQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2350093471</pqid></control><display><type>article</type><title>Single-suture craniosynostosis: is there a correlation between preoperative ophthalmological, neuroradiological, and neurocognitive findings?</title><source>SpringerNature Journals</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Chieffo, D. P. R. ; Arcangeli, V. ; Bianchi, F. ; Salerni, A. ; Massimi, L. ; Frassanito, P. ; Tamburrini, G.</creator><creatorcontrib>Chieffo, D. P. R. ; Arcangeli, V. ; Bianchi, F. ; Salerni, A. ; Massimi, L. ; Frassanito, P. ; Tamburrini, G.</creatorcontrib><description>Background
In spite of literature data stating that children with single-suture craniosynostosis have an increased risk for neuropsychological deficits, no data are present clarifying the potential risk factors.
Methods
All children with non-syndromic single-suture craniosynostosis operated on from January 2014 to January 2017 were enrolled. A comprehensive neurocognitive and neuro-ophthalmological evaluation was performed before surgery and 6 months after surgery. A further neurocognitive evaluation was performed 12 months after surgery. All children had a preoperative CT/MR study.
Results
One hundred forty-two patients were enrolled; 87 are affected by sagittal craniosynostosis, 38 by trigonocephaly, and 17 by plagiocephaly. A global neurocognitive impairment was documented in 22/87 children with scaphocephaly, 5/38 children with trigonocephaly, and 6/17 children with anterior plagiocephaly. There was a significant relationship between results of the ophthalmological evaluation, global IQ, and CT findings at diagnosis (
r
= 0.296,
p
< 0.001;
r
=0.187,
p
0.05). Though a significant recovery was documented after surgery, a persistence of eye coordination deficits was present at 6 months in 1 out of 3 children with abnormal preoperative exams. A significant correlation was found between pathological CT findings and persistence of below average neuro-ophthalmological and neurocognitive findings 6 months after surgery, as well as between CT findings and neurocognitive scores at the 1 year follow-up (
r
= 0.411;
p
< 0.01).
Conclusion
The presence of neuroradiological abnormalities appears to be related to both ophthalmological and neurocognitive deficits at diagnosis. This relationship is maintained in spite of the surgical treatment in children who show the persistence of ophthalmological and neurocognitive deficits during the follow-up.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-020-04521-w</identifier><identifier>PMID: 32006097</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Clinical Neurology ; Life Sciences & Biomedicine ; Medicine ; Medicine & Public Health ; Neurosciences ; Neurosciences & Neurology ; Neurosurgery ; Original Article ; Pediatrics ; Science & Technology ; Surgery</subject><ispartof>Child's nervous system, 2020-07, Vol.36 (7), p.1481-1488</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>16</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000515696000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c347t-72f3f68f486f577359b374849c9094c821b7d1abc7cf64d23bae19d545df7fb73</citedby><cites>FETCH-LOGICAL-c347t-72f3f68f486f577359b374849c9094c821b7d1abc7cf64d23bae19d545df7fb73</cites><orcidid>0000-0002-8216-8581</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00381-020-04521-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00381-020-04521-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,28253,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32006097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chieffo, D. P. R.</creatorcontrib><creatorcontrib>Arcangeli, V.</creatorcontrib><creatorcontrib>Bianchi, F.</creatorcontrib><creatorcontrib>Salerni, A.</creatorcontrib><creatorcontrib>Massimi, L.</creatorcontrib><creatorcontrib>Frassanito, P.</creatorcontrib><creatorcontrib>Tamburrini, G.</creatorcontrib><title>Single-suture craniosynostosis: is there a correlation between preoperative ophthalmological, neuroradiological, and neurocognitive findings?</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>CHILD NERV SYST</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Background
In spite of literature data stating that children with single-suture craniosynostosis have an increased risk for neuropsychological deficits, no data are present clarifying the potential risk factors.
Methods
All children with non-syndromic single-suture craniosynostosis operated on from January 2014 to January 2017 were enrolled. A comprehensive neurocognitive and neuro-ophthalmological evaluation was performed before surgery and 6 months after surgery. A further neurocognitive evaluation was performed 12 months after surgery. All children had a preoperative CT/MR study.
Results
One hundred forty-two patients were enrolled; 87 are affected by sagittal craniosynostosis, 38 by trigonocephaly, and 17 by plagiocephaly. A global neurocognitive impairment was documented in 22/87 children with scaphocephaly, 5/38 children with trigonocephaly, and 6/17 children with anterior plagiocephaly. There was a significant relationship between results of the ophthalmological evaluation, global IQ, and CT findings at diagnosis (
r
= 0.296,
p
< 0.001;
r
=0.187,
p
0.05). Though a significant recovery was documented after surgery, a persistence of eye coordination deficits was present at 6 months in 1 out of 3 children with abnormal preoperative exams. A significant correlation was found between pathological CT findings and persistence of below average neuro-ophthalmological and neurocognitive findings 6 months after surgery, as well as between CT findings and neurocognitive scores at the 1 year follow-up (
r
= 0.411;
p
< 0.01).
Conclusion
The presence of neuroradiological abnormalities appears to be related to both ophthalmological and neurocognitive deficits at diagnosis. This relationship is maintained in spite of the surgical treatment in children who show the persistence of ophthalmological and neurocognitive deficits during the follow-up.</description><subject>Clinical Neurology</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Science & Technology</subject><subject>Surgery</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqNkc1u1DAUhS0EotPCC7BAWSLRwHVsxwkbhEb8SZVYAGvLca5nXGXsYDuM-hC8M-6klB3CG0vH37m-OoeQZxReUQD5OgGwjtbQQA1cNLQ-PiAbyhmrgQl4SDbQiLaWwOGMnKd0DUBF1_SPyRlrAFro5Yb8-ur8bsI6LXmJWJmovQvpxoeUQ3LpTeVSlfdYnnRlQow46eyCrwbMR0RfzRHDjLGIP7EK8z7v9XQIU9g5o6fLyuMSQ9Sj-ytpP66yCTvvTj7r_FjWSG-fkEdWTwmf3t0X5PuH99-2n-qrLx8_b99d1YZxmWvZWGbbzvKutUJKJvqBSd7x3vTQc9M1dJAj1YORxrZ8bNigkfaj4GK00g6SXZAX69w5hh8LpqwOLhmcJu0xLEk1JT_oy1-0oM2KmhhSimjVHN1BxxtFQd3WoNYaVKlBnWpQx2J6fjd_GQ443lv-5F6AbgWOOASbjENv8B4DAEFF27dwe-jW5VPo27D4XKwv_99aaLbSqRB-h1FdhyX6Eu6_9v8NYoS4WQ</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Chieffo, D. P. R.</creator><creator>Arcangeli, V.</creator><creator>Bianchi, F.</creator><creator>Salerni, A.</creator><creator>Massimi, L.</creator><creator>Frassanito, P.</creator><creator>Tamburrini, G.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8216-8581</orcidid></search><sort><creationdate>20200701</creationdate><title>Single-suture craniosynostosis: is there a correlation between preoperative ophthalmological, neuroradiological, and neurocognitive findings?</title><author>Chieffo, D. P. R. ; Arcangeli, V. ; Bianchi, F. ; Salerni, A. ; Massimi, L. ; Frassanito, P. ; Tamburrini, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-72f3f68f486f577359b374849c9094c821b7d1abc7cf64d23bae19d545df7fb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Clinical Neurology</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosciences</topic><topic>Neurosciences & Neurology</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Science & Technology</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chieffo, D. P. R.</creatorcontrib><creatorcontrib>Arcangeli, V.</creatorcontrib><creatorcontrib>Bianchi, F.</creatorcontrib><creatorcontrib>Salerni, A.</creatorcontrib><creatorcontrib>Massimi, L.</creatorcontrib><creatorcontrib>Frassanito, P.</creatorcontrib><creatorcontrib>Tamburrini, G.</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chieffo, D. P. R.</au><au>Arcangeli, V.</au><au>Bianchi, F.</au><au>Salerni, A.</au><au>Massimi, L.</au><au>Frassanito, P.</au><au>Tamburrini, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-suture craniosynostosis: is there a correlation between preoperative ophthalmological, neuroradiological, and neurocognitive findings?</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><stitle>CHILD NERV SYST</stitle><addtitle>Childs Nerv Syst</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>36</volume><issue>7</issue><spage>1481</spage><epage>1488</epage><pages>1481-1488</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Background
In spite of literature data stating that children with single-suture craniosynostosis have an increased risk for neuropsychological deficits, no data are present clarifying the potential risk factors.
Methods
All children with non-syndromic single-suture craniosynostosis operated on from January 2014 to January 2017 were enrolled. A comprehensive neurocognitive and neuro-ophthalmological evaluation was performed before surgery and 6 months after surgery. A further neurocognitive evaluation was performed 12 months after surgery. All children had a preoperative CT/MR study.
Results
One hundred forty-two patients were enrolled; 87 are affected by sagittal craniosynostosis, 38 by trigonocephaly, and 17 by plagiocephaly. A global neurocognitive impairment was documented in 22/87 children with scaphocephaly, 5/38 children with trigonocephaly, and 6/17 children with anterior plagiocephaly. There was a significant relationship between results of the ophthalmological evaluation, global IQ, and CT findings at diagnosis (
r
= 0.296,
p
< 0.001;
r
=0.187,
p
0.05). Though a significant recovery was documented after surgery, a persistence of eye coordination deficits was present at 6 months in 1 out of 3 children with abnormal preoperative exams. A significant correlation was found between pathological CT findings and persistence of below average neuro-ophthalmological and neurocognitive findings 6 months after surgery, as well as between CT findings and neurocognitive scores at the 1 year follow-up (
r
= 0.411;
p
< 0.01).
Conclusion
The presence of neuroradiological abnormalities appears to be related to both ophthalmological and neurocognitive deficits at diagnosis. This relationship is maintained in spite of the surgical treatment in children who show the persistence of ophthalmological and neurocognitive deficits during the follow-up.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32006097</pmid><doi>10.1007/s00381-020-04521-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8216-8581</orcidid></addata></record> |
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| ispartof | Child's nervous system, 2020-07, Vol.36 (7), p.1481-1488 |
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| source | SpringerNature Journals; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Clinical Neurology Life Sciences & Biomedicine Medicine Medicine & Public Health Neurosciences Neurosciences & Neurology Neurosurgery Original Article Pediatrics Science & Technology Surgery |
| title | Single-suture craniosynostosis: is there a correlation between preoperative ophthalmological, neuroradiological, and neurocognitive findings? |
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