Abnormal overexpression of G9a in melanoma cells promotes cancer progression via upregulation of the Notch1 signaling pathway

Malignant melanoma is a type of very dangerous skin cancer. Histone modifiers usually become dysregulated during the process of carcinoma development, thus there is potential for a histone modifier inhibitor as a useful drug for cancer therapy. There is a multitude of evidence regarding the role of...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2020-02, Vol.12 (3), p.2393-2407
Hauptverfasser:	Dang, Ning-Ning, Jiao, Jing, Meng, Xianguang, An, Yunhe, Han, Chen, Huang, Shuhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Cell Biology Disease Progression Female Geriatrics & Gerontology Heterografts Histocompatibility Antigens - metabolism Histone-Lysine N-Methyltransferase - metabolism Humans Life Sciences & Biomedicine Male Melanoma - pathology Melanoma, Cutaneous Malignant Mice Receptor, Notch1 - metabolism Research Paper Science & Technology Signal Transduction - physiology Skin Neoplasms - pathology Up-Regulation
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