Allergen alters IL‐2/αIL‐2‐based Treg expansion but not tolerance induction in an allergen‐specific mouse model

Background Regulatory T lymphocytes (Treg) play an important role in preventing allergic diseases. We characterized Treg expansion kinetics, marker profiles, and recirculation behavior in allergen‐challenged mice, which had been pretreated with IL‐2/αIL‐2 complexes in the presence or absence of alle...

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Veröffentlicht in:	Allergy (Copenhagen) 2020-07, Vol.75 (7), p.1618-1629
Hauptverfasser:	Köhler, Cordula, Smole, Ursula, Kratzer, Bernhard, Trapin, Doris, Schmetterer, Klaus G., Pickl, Winfried F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens Allergic diseases Allergy allergy treatment Animals CD25 antigen CTLA-4 protein Flow cytometry Histocompatibility antigen HLA Hypersensitivity IL‐2/αIL‐2 complexes Immune Tolerance Immunological tolerance Immunology Immunotherapy immunotherapy and tolerance induction Interleukin-2 Life Sciences & Biomedicine Lymphocytes Lymphocytes T Mice Original ORIGINAL ARTICLES Peripheral blood Phenotypes Respiratory tract Science & Technology T cell receptors T cells T-Lymphocytes, Regulatory Transcription Transgenic mice Treg cells
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