Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes
BackgroundTo explore the effect of aerobic training (AT), resistance training (RT) or a combination of AT and RT (AT+RT) on the function of endothelial progenitor cells (EPCs) in mice with type 2 diabetes and the potential effective mechanismsMethodsEight-week-old db/db male mice were used as type 2...
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| description | BackgroundTo explore the effect of aerobic training (AT), resistance training (RT) or a combination of AT and RT (AT+RT) on the function of endothelial progenitor cells (EPCs) in mice with type 2 diabetes and the potential effective mechanismsMethodsEight-week-old db/db male mice were used as type 2 diabetic animal models in this study. Mice were randomly assigned to the control group (n=5), AT group (n=5), RT group (n=5) and AT+RT group (n=5). Mice in the control group remained sedentary with no specific training requirement. Mice were motivated to perform AT, RT or AT+RT by a gentle pat on their body for 3 or 4days/week for 14days. AT was performed by treadmill running, RT was performed by ladder climbing and AT+RT involved both AT and RT. Bone-derived EPCs were isolated after 14days of the intervention. EPC expression of CD31, CD34, CD133, CD144 and VEGFR2 was detected by immunofluorescence staining. Fluorescence detection was performed on attached mononuclear cells to detect double-positive EPCs. We then explored the effect of caveolin-1 knockdown (lentiviral vector with caveolin-1-siRNA) on the proliferation and adherence of EPCs and the concentration of caveolin-1 and PI3K/AKT via western blot analyses.ResultsCompared to the mice in the control group, the mice in the AT, RT and AT+RT groups presented significant increases in proliferation and adherence after 14days of intervention. AT+RT induced an increase in EPC adherence, which was greater than that of the control, RT and AT groups. Caveolin-1 knockdown inhibited the EPC proliferative and adherent abilities. The AT+RT group showed higher levels of caveolin-1 and p-AKT than the control group, but these changes were decreased by caveolin-1-siRNA transfection.ConclusionCombined AT and RT is an effective way to improve EPC function through upregulation of caveolin-1 in mice with type 2 diabetes. |
| doi_str_mv | 10.1186/s13287-019-1527-z |
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Mice were randomly assigned to the control group (n=5), AT group (n=5), RT group (n=5) and AT+RT group (n=5). Mice in the control group remained sedentary with no specific training requirement. Mice were motivated to perform AT, RT or AT+RT by a gentle pat on their body for 3 or 4days/week for 14days. AT was performed by treadmill running, RT was performed by ladder climbing and AT+RT involved both AT and RT. Bone-derived EPCs were isolated after 14days of the intervention. EPC expression of CD31, CD34, CD133, CD144 and VEGFR2 was detected by immunofluorescence staining. Fluorescence detection was performed on attached mononuclear cells to detect double-positive EPCs. We then explored the effect of caveolin-1 knockdown (lentiviral vector with caveolin-1-siRNA) on the proliferation and adherence of EPCs and the concentration of caveolin-1 and PI3K/AKT via western blot analyses.ResultsCompared to the mice in the control group, the mice in the AT, RT and AT+RT groups presented significant increases in proliferation and adherence after 14days of intervention. AT+RT induced an increase in EPC adherence, which was greater than that of the control, RT and AT groups. Caveolin-1 knockdown inhibited the EPC proliferative and adherent abilities. The AT+RT group showed higher levels of caveolin-1 and p-AKT than the control group, but these changes were decreased by caveolin-1-siRNA transfection.ConclusionCombined AT and RT is an effective way to improve EPC function through upregulation of caveolin-1 in mice with type 2 diabetes.</description><identifier>ISSN: 1757-6512</identifier><identifier>EISSN: 1757-6512</identifier><identifier>DOI: 10.1186/s13287-019-1527-z</identifier><identifier>PMID: 31900223</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>1-Phosphatidylinositol 3-kinase ; Aerobic and resistance training ; Aerobics ; AKT protein ; Analysis ; Animal models ; Animals ; Bone marrow ; Cardiovascular disease ; Caveolin ; Caveolin 1 - metabolism ; Caveolin-1 ; CD34 antigen ; Cell & Tissue Engineering ; Cell Biology ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - metabolism ; Endothelial progenitor cell ; Endothelial Progenitor Cells - physiology ; Endothelium ; Exercise ; Fitness equipment ; Fluorescence ; Fluorescent antibody technique ; Humans ; Immunofluorescence ; Leukocytes (mononuclear) ; Life Sciences & Biomedicine ; Male ; Medical research ; Medicine, Research & Experimental ; Metabolism ; Mice ; Physical fitness ; Physical training ; Progenitor cells ; Research & Experimental Medicine ; Resistance Training - methods ; Running ; Science ; Science & Technology ; siRNA ; Stem cells ; Strength training ; Transfection ; Type 2 diabetes ; Up-Regulation ; Weight training</subject><ispartof>Stem cell research & therapy, 2020-01, Vol.11 (1), p.10-10, Article 10</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>12</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000513179500010</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c625t-7f6759ee2fd28bbc15faebbd2d616e18047ebb526b2e598b0431011244ef62383</citedby><cites>FETCH-LOGICAL-c625t-7f6759ee2fd28bbc15faebbd2d616e18047ebb526b2e598b0431011244ef62383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942272/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942272/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31900223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhai, Lu</creatorcontrib><creatorcontrib>Liu, Yuhua</creatorcontrib><creatorcontrib>Zhao, Wenpiao</creatorcontrib><creatorcontrib>Chen, Qingyun</creatorcontrib><creatorcontrib>Guo, Tao</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Luo, Zhuchun</creatorcontrib><creatorcontrib>Huang, Yanfeng</creatorcontrib><creatorcontrib>Ma, Cui</creatorcontrib><creatorcontrib>Huang, Feng</creatorcontrib><creatorcontrib>Dai, Xia</creatorcontrib><title>Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes</title><title>Stem cell research & therapy</title><addtitle>STEM CELL RES THER</addtitle><addtitle>Stem Cell Res Ther</addtitle><description>BackgroundTo explore the effect of aerobic training (AT), resistance training (RT) or a combination of AT and RT (AT+RT) on the function of endothelial progenitor cells (EPCs) in mice with type 2 diabetes and the potential effective mechanismsMethodsEight-week-old db/db male mice were used as type 2 diabetic animal models in this study. Mice were randomly assigned to the control group (n=5), AT group (n=5), RT group (n=5) and AT+RT group (n=5). Mice in the control group remained sedentary with no specific training requirement. Mice were motivated to perform AT, RT or AT+RT by a gentle pat on their body for 3 or 4days/week for 14days. AT was performed by treadmill running, RT was performed by ladder climbing and AT+RT involved both AT and RT. Bone-derived EPCs were isolated after 14days of the intervention. EPC expression of CD31, CD34, CD133, CD144 and VEGFR2 was detected by immunofluorescence staining. Fluorescence detection was performed on attached mononuclear cells to detect double-positive EPCs. We then explored the effect of caveolin-1 knockdown (lentiviral vector with caveolin-1-siRNA) on the proliferation and adherence of EPCs and the concentration of caveolin-1 and PI3K/AKT via western blot analyses.ResultsCompared to the mice in the control group, the mice in the AT, RT and AT+RT groups presented significant increases in proliferation and adherence after 14days of intervention. AT+RT induced an increase in EPC adherence, which was greater than that of the control, RT and AT groups. Caveolin-1 knockdown inhibited the EPC proliferative and adherent abilities. The AT+RT group showed higher levels of caveolin-1 and p-AKT than the control group, but these changes were decreased by caveolin-1-siRNA transfection.ConclusionCombined AT and RT is an effective way to improve EPC function through upregulation of caveolin-1 in mice with type 2 diabetes.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Aerobic and resistance training</subject><subject>Aerobics</subject><subject>AKT protein</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Bone marrow</subject><subject>Cardiovascular disease</subject><subject>Caveolin</subject><subject>Caveolin 1 - metabolism</subject><subject>Caveolin-1</subject><subject>CD34 antigen</subject><subject>Cell & Tissue Engineering</subject><subject>Cell Biology</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Endothelial progenitor cell</subject><subject>Endothelial Progenitor Cells - physiology</subject><subject>Endothelium</subject><subject>Exercise</subject><subject>Fitness equipment</subject><subject>Fluorescence</subject><subject>Fluorescent antibody technique</subject><subject>Humans</subject><subject>Immunofluorescence</subject><subject>Leukocytes (mononuclear)</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Research & Experimental</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Progenitor cells</subject><subject>Research & Experimental Medicine</subject><subject>Resistance Training - methods</subject><subject>Running</subject><subject>Science</subject><subject>Science & Technology</subject><subject>siRNA</subject><subject>Stem cells</subject><subject>Strength training</subject><subject>Transfection</subject><subject>Type 2 diabetes</subject><subject>Up-Regulation</subject><subject>Weight training</subject><issn>1757-6512</issn><issn>1757-6512</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk8tq3DAUhk1paUKaB-imCAqlpTjVxZbsTSAMvQQChV7WQpKPPAoeaSrJSZM36FtXM5OGTOmi9sJHx9__2z76XVXPCT4hpOPvEmG0EzUmfU1aKurbR9UhEa2oeUvo4wf1QXWc0iUuB2MY8-ZpdcBIjzGl7LD6dQYxaGeQ8gOKkFzKyhtAOSrnnR8R-OWmkUoxhLyEyakJrWMYwbscIjIwTcjO3mQXPLpyCs3rCOM8qW0jWGTUFYTJ-Zog59HKFfdrl5co36wBUTQ4pSFDelY9sWpKcHx3Paq-f3j_bfGpvvj88XxxdlEbTttcC8tF2wNQO9BOa0Naq0DrgQ6ccCAdbkRZtpRrCm3fadwwggmhTQOWU9axo-p85zsEdSnX0a1UvJFBOblthDhKFbMzE0jdWqwoFlb3uumZUmXZaNXQlmDDOC9epzuv9axXMBjwZW7Tnun-He-WcgxXkvcNpYIWg9d3BjH8mCFluXJpM1LlIcxJUsYYL_vGRUFf_oVehjn6MqpCNYSwHm_f6I4aVfkA520ozzUbU3nGSSd4K0oOjqqTf1DlHKDsT_BgXenvCd7sCQqT4Wce1ZySPP_6ZZ999YBdgpryMoVp3uQh7YNkB5oYUopg7wdHsNxkXO4yLkvG5Sbj8rZoXjyc-L3iT6IL0O2Aa9DBJuOgpPceKz9BSxgRfVsqghcub2O6CLPPRfr2_6XsN2lbFtY</recordid><startdate>20200103</startdate><enddate>20200103</enddate><creator>Zhai, Lu</creator><creator>Liu, Yuhua</creator><creator>Zhao, Wenpiao</creator><creator>Chen, Qingyun</creator><creator>Guo, Tao</creator><creator>Wei, Wei</creator><creator>Luo, Zhuchun</creator><creator>Huang, Yanfeng</creator><creator>Ma, Cui</creator><creator>Huang, Feng</creator><creator>Dai, Xia</creator><general>Springer Nature</general><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200103</creationdate><title>Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes</title><author>Zhai, Lu ; Liu, Yuhua ; Zhao, Wenpiao ; Chen, Qingyun ; Guo, Tao ; Wei, Wei ; Luo, Zhuchun ; Huang, Yanfeng ; Ma, Cui ; Huang, Feng ; Dai, Xia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c625t-7f6759ee2fd28bbc15faebbd2d616e18047ebb526b2e598b0431011244ef62383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>Aerobic and resistance training</topic><topic>Aerobics</topic><topic>AKT protein</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Bone marrow</topic><topic>Cardiovascular disease</topic><topic>Caveolin</topic><topic>Caveolin 1 - metabolism</topic><topic>Caveolin-1</topic><topic>CD34 antigen</topic><topic>Cell & Tissue Engineering</topic><topic>Cell Biology</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Endothelial progenitor cell</topic><topic>Endothelial Progenitor Cells - physiology</topic><topic>Endothelium</topic><topic>Exercise</topic><topic>Fitness equipment</topic><topic>Fluorescence</topic><topic>Fluorescent antibody technique</topic><topic>Humans</topic><topic>Immunofluorescence</topic><topic>Leukocytes (mononuclear)</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Research & Experimental</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Physical fitness</topic><topic>Physical training</topic><topic>Progenitor cells</topic><topic>Research & Experimental Medicine</topic><topic>Resistance Training - methods</topic><topic>Running</topic><topic>Science</topic><topic>Science & Technology</topic><topic>siRNA</topic><topic>Stem cells</topic><topic>Strength training</topic><topic>Transfection</topic><topic>Type 2 diabetes</topic><topic>Up-Regulation</topic><topic>Weight training</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhai, Lu</creatorcontrib><creatorcontrib>Liu, Yuhua</creatorcontrib><creatorcontrib>Zhao, Wenpiao</creatorcontrib><creatorcontrib>Chen, Qingyun</creatorcontrib><creatorcontrib>Guo, Tao</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Luo, Zhuchun</creatorcontrib><creatorcontrib>Huang, Yanfeng</creatorcontrib><creatorcontrib>Ma, Cui</creatorcontrib><creatorcontrib>Huang, Feng</creatorcontrib><creatorcontrib>Dai, Xia</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Stem cell research & therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhai, Lu</au><au>Liu, Yuhua</au><au>Zhao, Wenpiao</au><au>Chen, Qingyun</au><au>Guo, Tao</au><au>Wei, Wei</au><au>Luo, Zhuchun</au><au>Huang, Yanfeng</au><au>Ma, Cui</au><au>Huang, Feng</au><au>Dai, Xia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes</atitle><jtitle>Stem cell research & therapy</jtitle><stitle>STEM CELL RES THER</stitle><addtitle>Stem Cell Res Ther</addtitle><date>2020-01-03</date><risdate>2020</risdate><volume>11</volume><issue>1</issue><spage>10</spage><epage>10</epage><pages>10-10</pages><artnum>10</artnum><issn>1757-6512</issn><eissn>1757-6512</eissn><abstract>BackgroundTo explore the effect of aerobic training (AT), resistance training (RT) or a combination of AT and RT (AT+RT) on the function of endothelial progenitor cells (EPCs) in mice with type 2 diabetes and the potential effective mechanismsMethodsEight-week-old db/db male mice were used as type 2 diabetic animal models in this study. Mice were randomly assigned to the control group (n=5), AT group (n=5), RT group (n=5) and AT+RT group (n=5). Mice in the control group remained sedentary with no specific training requirement. Mice were motivated to perform AT, RT or AT+RT by a gentle pat on their body for 3 or 4days/week for 14days. AT was performed by treadmill running, RT was performed by ladder climbing and AT+RT involved both AT and RT. Bone-derived EPCs were isolated after 14days of the intervention. EPC expression of CD31, CD34, CD133, CD144 and VEGFR2 was detected by immunofluorescence staining. Fluorescence detection was performed on attached mononuclear cells to detect double-positive EPCs. We then explored the effect of caveolin-1 knockdown (lentiviral vector with caveolin-1-siRNA) on the proliferation and adherence of EPCs and the concentration of caveolin-1 and PI3K/AKT via western blot analyses.ResultsCompared to the mice in the control group, the mice in the AT, RT and AT+RT groups presented significant increases in proliferation and adherence after 14days of intervention. AT+RT induced an increase in EPC adherence, which was greater than that of the control, RT and AT groups. Caveolin-1 knockdown inhibited the EPC proliferative and adherent abilities. The AT+RT group showed higher levels of caveolin-1 and p-AKT than the control group, but these changes were decreased by caveolin-1-siRNA transfection.ConclusionCombined AT and RT is an effective way to improve EPC function through upregulation of caveolin-1 in mice with type 2 diabetes.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>31900223</pmid><doi>10.1186/s13287-019-1527-z</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase Aerobic and resistance training Aerobics AKT protein Analysis Animal models Animals Bone marrow Cardiovascular disease Caveolin Caveolin 1 - metabolism Caveolin-1 CD34 antigen Cell & Tissue Engineering Cell Biology Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Endothelial progenitor cell Endothelial Progenitor Cells - physiology Endothelium Exercise Fitness equipment Fluorescence Fluorescent antibody technique Humans Immunofluorescence Leukocytes (mononuclear) Life Sciences & Biomedicine Male Medical research Medicine, Research & Experimental Metabolism Mice Physical fitness Physical training Progenitor cells Research & Experimental Medicine Resistance Training - methods Running Science Science & Technology siRNA Stem cells Strength training Transfection Type 2 diabetes Up-Regulation Weight training |
| title | Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T12%3A39%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aerobic%20and%20resistance%20training%20enhances%20endothelial%20progenitor%20cell%20function%20via%20upregulation%20of%20caveolin-1%20in%20mice%20with%20type%202%20diabetes&rft.jtitle=Stem%20cell%20research%20&%20therapy&rft.au=Zhai,%20Lu&rft.date=2020-01-03&rft.volume=11&rft.issue=1&rft.spage=10&rft.epage=10&rft.pages=10-10&rft.artnum=10&rft.issn=1757-6512&rft.eissn=1757-6512&rft_id=info:doi/10.1186/s13287-019-1527-z&rft_dat=%3Cgale_webof%3EA618765700%3C/gale_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2341139066&rft_id=info:pmid/31900223&rft_galeid=A618765700&rft_doaj_id=oai_doaj_org_article_b5f0a207fb9b493aaf0a4ba42510c366&rfr_iscdi=true |